IkB-beta Products

Description

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]

Bioinformatics

Entrez	18036 Mouse 4793 Human 81525 Rat
Uniprot	AAH15528 Human NM_002503 Human NP_002494.2 Human Q15653 Human
Product By Gene ID	4793
Alternate Names	beta IkappaBbeta I-kappa-B-beta IkB-B ikB-B IkB-beta IKBBikB-beta NF-kappa-B inhibitor beta NF-kappa-BIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor Thyroid receptor-interacting protein 9 TR-interacting protein 9 TRIP-9 TRIP9ikappaBbeta

Diseases related to IkB-beta

Discover more about diseases related to IkB-beta.

Inflammation
Malignant Neoplasms
Liver Diseases
Neoplasm Metastasis
Infarction
Malignant Neoplasm Of Breast
Communicable Diseases
Endometrial Polyp
Lung Diseases
Inflammatory Breast Carcinoma
Inflammatory Response
Chronic Obstructive Airway Disease
Lung Diseases, Obstructive
Immunologic Deficiency Syndromes
Myocardial Infarction
Tumor Angiogenesis
Neoplasms
Cerebrovascular Accident
Asthma

Pathways for IkB-beta

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Response To Oxidative Stress
Cell Proliferation
Cellular Localization
Immune Response
Regulation Of Gene Expression
Angiogenesis
Pathogenesis
Localization
Inflammatory Response

Research Areas for IkB-beta

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Immunology
Innate Immunity
Phospho-Specific

PTMs for IkB-beta

Learn more about PTMs related to IkB-beta.

Phosphorylation

Bioinformatics Tool for IkB-beta

Discover related pathways, diseases and genes to IkB-beta. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.