ICOS Antibody


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Product Details

Reactivity Hu, MuSpecies Glossary
Applications PEP-ELISA
0.5 mg/ml

Order Details

ICOS Antibody Summary

Peptide with sequence KGGQILCDLTKTKGS corresponding to internal region according to NP_036224.1.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
Tris saline, pH 7.3 with 0.5% BSA.
0.02% Sodium Azide
0.5 mg/ml
Immunogen affinity purified


Application Notes
WB: Preliminary experiments gave an approx. 13 kDa band in human peripheral blood Lymphocyte lysates after 0.01 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 22.6 kDa band according to NP_036224.1. The 13 kDa band was successfully blocked by incubation with the immunizing peptide.
Read Publication using NBP1-52139.


Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for ICOS Antibody

  • Activation-inducible lymphocyte immunomediatory molecule
  • AILIMCD278
  • CD278 antigen
  • CD278
  • CRP-1
  • CVID1
  • inducible costimulator
  • inducible T-cell costimulator
  • inducible T-cell co-stimulator
  • MGC39850


CD278 is a 47-57 kD protein, also known as inducible costimulatory molecule (ICOS), or H4. This protein is homologous to the CD28/CTLA-4 proteins. It forms homodimers and is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. It has also been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for ICOS Antibody (NBP1-52139)(1)

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Secondary Antibodies


Isotype Controls

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Contact Information

Product PDFs


Gene Symbol ICOS

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