Applications: B/N, Flow, CyTOF-ready
Host: Mouse Monoclonal
IHC, IHC-P, PEP-ELISAHost:
Applications: Flow, CyTOF-ready
Host: Rat Monoclonal
Applications: RNAi, RNAi SP
The C398.4A antibody reacts with the human, mouse and rat 47-57 kD ICOS protein, also known as inducible costimulatory molecule and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation.
|Product By Gene ID
- CD278 antigen
- inducible T-cell costimulator
- Activation-inducible lymphocyte immunomediatory molecule
- inducible costimulator
- inducible T-cell co-stimulator
Bioinformatics Tool for ICOS
Discover related pathways, diseases and genes to ICOS. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.