Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
Species: Hu
Applications: Flow, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA, IHC
Host: Goat Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Bioactivity
Species: Mu
Applications: Binding Activity
Species: Hu
Applications: Bioactivity
Description
The C398.4A antibody reacts with the human, mouse and rat 47-57 kD ICOS protein, also known as inducible costimulatory molecule and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation.
Bioinformatics
| Entrez |
Human
Mouse
Rat
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
29851 |
| Alternate Names |
- Activation-inducible lymphocyte immunomediatory molecule
- AILIMCD278
- CD278 antigen
- CVID1
- inducible costimulator
- inducible T-cell costimulator
- inducible T-cell co-stimulator
- MGC39850
|
![N/A ICOS [Biotin]](http://images.novusbio.com/fullsize2/DATA_ICOS_DY169_ELISA_1698.jpg)
![Bioactivity ICOS [Unconjugated]](http://images.novusbio.com/fullsize2/ICOS_169CS_2302.jpg)
![Binding Activity ICOS [Unconjugated]](http://images.novusbio.com/fullsize/11423-cs_recombinant-human-icos-aa-21-140-mfc-chimera-protein-cf-binding-affinity-1492023132840.jpg)
![SDS-PAGE ICOS [Unconjugated]](http://images.novusbio.com/fullsize/11423-cs_recombinant-human-icos-aa-21-140-mfc-chimera-protein-cf-sds-page-149202313415.jpg)