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The C398.4A antibody reacts with the human, mouse and rat 47-57 kD ICOS protein, also known as inducible costimulatory molecule and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation.
![N/A ICOS [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_ICOS_DY169_ELISA_1698.jpg)
![Bioactivity ICOS [Unconjugated]](http://images.novusbio.com/fullsize/protein/ICOS_169CS_2302.jpg)
![Binding Activity ICOS [Unconjugated]](http://images.novusbio.com/fullsize/protein/ICOS_9865CS_1967.jpg)
![SDS-Page ICOS [Unconjugated]](http://images.novusbio.com/fullsize/protein/ICOS_9865CS_1947.jpg)