ICOS Antibody (AP-MAB0857) - Azide and BSA Free

• Reactivity: Mu
• Applications: Flow, CyTOF-ready, Func
• Clone: AP-MAB0857
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: 1.0 mg/ml

ICOS Antibody (AP-MAB0857) - Azide and BSA Free Summary

• Description: Novus Biologicals Rat ICOS Antibody (AP-MAB0857) - Azide and BSA Free (NBP1-06686) is a monoclonal antibody validated for use in Flow. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Mouse ICOS recombinant protein
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Rat
• Gene: ICOS
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry 1:10-1:1000
  • T Cell Stimulation
• Application Notes: Flow Cytometry, Costimulating T cell activation, proliferation, and humoral immune response. Extremely low level of LPS (< 0.002EU/ug IgG). This antibody is CyTOF ready.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Concentration: 1.0 mg/ml
• Purity: Protein A or G purified

Alternate Names for ICOS Antibody (AP-MAB0857) - Azide and BSA Free

• Activation-inducible lymphocyte immunomediatory molecule
• AILIM
• AILIMCD278
• CD278 antigen
• CD278
• CRP-1
• CVID1
• ICOS
• inducible costimulator
• inducible T-cell costimulator
• inducible T-cell co-stimulator
• MGC39850

Background

ICOS, a protein of 47-57kD, is also known as inducible costimulatory molecule and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes and can costimulate T cells and induce proliferation. In addition ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand, B7h/B7RP-1 and B7-H2 is constitutively expressed in B cell areas of secondary lymphoid organs and can be induced in other tissues by LPS. ICOS stimulation has been shown to potentiate TCR mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. ICOS stimulation has been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ICOS
• Entrez:
  • 54167(Mouse)