Human TREM-1 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human TREM-1 Quantikine ELISA Kit Summary

• Background: The Quantikine Human TREM-1 Immunoassay is a 4.5 hour solid phase ELISA designed to measure TREM-1 levels in cell culture supernates, cell lysates, serum, plasma, and saliva. It contains NS0-expressed recombinant human TREM-1 and antibodies raised against the recombinant protein. Results obtained for naturally occurring human TREM-1 showed linear curves that were parallel to the standard cur...ves obtained using the Quantikine Human TREM-1 Immunoassay standards. These results indicate that this kit can be used to determine relative mass values for natural human TREM-1.
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• Specificity: Natural and recombinant human TREM-1.
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: TREM1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TREM-1 Quantikine ELISA Kit

• CD354 antigen
• CD354
• TREM1
• TREM-1
• TREM-1Triggering receptor expressed on monocytes 1
• triggering receptor expressed on myeloid cells 1
• triggering-receptor TREM1

Background

The TREM family of receptors regulates the activity of various cell types of the immune system including neutrophils, monocyte/macrophages, microglia, and dendritic cells. The receptors are members of the immunoglobulin superfamily, characterized structurally by a single V-set immunoglobulin (Ig) domain and a short cytoplasmic tail. TREMs associate with the DAP12 signal adapter, an immunoreceptor tyrosine-based activation motif- (ITAM)-containing protein that is phosphorylated and transduces signals when activated.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TREM1 (DTRM10C)(14)

Publications using DTRM10C

• V Montiel, I Lobysheva, L Gérard, M Vermeersch, D Perez-Morg, T Castelein, JB Mesland, P Hantson, C Collienne, D Gruson, MA van Dievoe, A Persu, C Beauloye, M Dechamps, L Belkhir, A Robert, M Derive, PF Laterre, AHJ Danser, X Wittebole, JL Balligand Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients EBioMedicine, 2022;77(0):103893. 2022-01-01 [PMID: 35219085] (Human)
• AH de Nooijer, I Grondman, S Lambden, EJ Kooistra, NA Janssen, M Kox, P Pickkers, LA Joosten, F van de Vee, M Derive, S Gibot, MG Netea Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19 Bioscience Reports, 2021;0(0):. 2021-01-01 [PMID: 34195785] (Human)
• W Chang, F Peng, SS Meng, JY Xu, Y Yang Diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis: a meta-analysis BMC Immunol., 2020;21(1):2. 2020-01-01 [PMID: 31931717] (Human)
• Y He, Q Yang, X Wang, A Jia, W Xie, J Zhou Inhibition of Triggering Receptor Expressed on Myeloid Cell-1 Alleviates Acute Gouty Inflammation Mediators Inflamm., 2019;2019(0):5647074. 2019-01-01 [PMID: 31885496] (Human)
• J Hyun, RS McMahon, AL Lang, JS Edwards, AD Badilla, ME Greene, GW Stone, S Pallikkuth, M Stevenson, DM Dykxhoorn, S Kottilil, S Pahwa, E Thomas HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells PLoS Pathog., 2019;15(7):e1007883. 2019-01-01 [PMID: 31260499] (Human)
• JY Feng, WJ Su, SW Pan, YC Yeh, YY Lin, NJ Chen Role of TREM-1 in pulmonary tuberculosis patients- analysis of serum soluble TREM-1 levels Sci Rep, 2018;8(1):8223. 2018-01-01 [PMID: 29844416] (Human)
• AA Arguinano, NC Ndiaye, C Masson, S Visvikis-S Pleiotropy of ABO gene: correlation of rs644234 with E-selectin and lipid levels Clin. Chem. Lab. Med., 2018;0(0):. 2018-01-01 [PMID: 29373315] (Human)
• AA Aldasoro A, S Dadé, M Stathopoul, M Derive, N Coumba Ndi, T Xie, C Masson, S Gibot, S Visvikis-S TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin PLoS ONE, 2017;12(8):e0182226. 2017-01-01 [PMID: 28771614] (Human)
• E Sierra-Dia, A Bravo Cuél, PC Ortiz Laza, M García Gut, HF Georgina, R Anaya Prad Urine TREM-1 as a marker of urinary tract infection in children J. Int. Med. Res., 2017;45(2):631-638. 2017-01-01 [PMID: 28367708] (Human)
• Chen CY, Yang KY, Chen MY, Chen HY, Lin MT, Lee YC, Perng RP, Hsieh SL, Yang PC, Chou TY Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med., 2009;180(8):751-60. 2009-01-01 [PMID: 19644047] (Human)
• Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis. Arthritis Rheum., 2009;60(6):1615-23. 2009-01-01 [PMID: 19479878] (Human)
• Park JJ, Cheon JH, Kim BY, Kim DH, Kim ES, Kim TI, Lee KR, Kim WH Correlation of serum-soluble triggering receptor expressed on myeloid cells-1 with clinical disease activity in inflammatory bowel disease. Dig. Dis. Sci., 2009;54(7):1525-31. 2009-01-01 [PMID: 18975078] (Human)
• Yasuda T, Takeyama Y, Ueda T, Shinzeki M, Sawa H, Takahiro N, Kamei K, Ku Y, Kuroda Y, Ohyanagi H Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis. Crit. Care Med., 2008;36(7):2048-53. 2008-01-01 [PMID: 18552693] (Human)
• Ho CC, Liao WY, Wang CY, Lu YH, Huang HY, Chen HY, Chan WK, Chen HW, Yang PC TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer. Am. J. Respir. Crit. Care Med., 2007;177(7):763-70. 2007-01-01 [PMID: 18096709] (Human)

Bioinformatics

• Gene Symbol: TREM1