Human TREM-1 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human TREM-1 Quantikine ELISA Kit Summary

• Background: The Quantikine Human TREM-1 Immunoassay is a 4.5 hour solid phase ELISA designed to measure TREM-1 levels in cell culture supernates, cell lysates, serum, plasma, and saliva. It contains NS0-expressed recombinant human TREM-1 and antibodies raised against the recombinant protein. Results obtained for naturally occurring human TREM-1 showed linear curves that were parallel to the standard cur...ves obtained using the Quantikine Human TREM-1 Immunoassay standards. These results indicate that this kit can be used to determine relative mass values for natural human TREM-1.
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• Specificity: Natural and recombinant human TREM-1.
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: TREM1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TREM-1 Quantikine ELISA Kit

• CD354 antigen
• CD354
• TREM1
• TREM-1
• TREM-1Triggering receptor expressed on monocytes 1
• triggering receptor expressed on myeloid cells 1
• triggering-receptor TREM1

Background

The TREM family of receptors regulates the activity of various cell types of the immune system including neutrophils, monocyte/macrophages, microglia, and dendritic cells. The receptors are members of the immunoglobulin superfamily, characterized structurally by a single V-set immunoglobulin (Ig) domain and a short cytoplasmic tail. TREMs associate with the DAP12 signal adapter, an immunoreceptor tyrosine-based activation motif- (ITAM)-containing protein that is phosphorylated and transduces signals when activated.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for TREM1 (DTRM10C)(18)

Publications using DTRM10C

• Kim, H;Kim, J;Park, S;Kim, J;Gwon, Y;Lee, M;Park, S; Porcine-Derived Chondroitin Sulfate Sodium Alleviates Osteoarthritis in HTB-94 Cells and MIA-Induced SD Rat Models International journal of molecular sciences 2025-01-09 [PMID: 39859238] (Human)
• Baek, S;Park, I;Kim, S;Um, YW;Kim, HE;Lee, K;Lee, JH;Jo, YH; Urinary biomarkers for diagnosing acute kidney injury in sepsis in the emergency department Heliyon 2025-01-15 [PMID: 39811377] (Human)
• Balerdi-Sarasola, L;Parolo, C;Fleitas, P;Cruz, A;Subirà, C;Rodríguez-Valero, N;Almuedo-Riera, A;Letona, L;Álvarez-Martínez, MJ;Valls, ME;Vera, I;Mayor, A;Muñoz, J;Camprubí-Ferrer, D; Host biomarkers for early identification of severe imported Plasmodium falciparum malaria Travel medicine and infectious disease 2023-06-20 [PMID: 37348666] (Human)
• V Montiel, I Lobysheva, L Gérard, M Vermeersch, D Perez-Morg, T Castelein, JB Mesland, P Hantson, C Collienne, D Gruson, MA van Dievoe, A Persu, C Beauloye, M Dechamps, L Belkhir, A Robert, M Derive, PF Laterre, AHJ Danser, X Wittebole, JL Balligand Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients EBioMedicine, 2022-02-23;77(0):103893. 2022-02-23 [PMID: 35219085] (Human)
• AH de Nooijer, I Grondman, S Lambden, EJ Kooistra, NA Janssen, M Kox, P Pickkers, LA Joosten, F van de Vee, M Derive, S Gibot, MG Netea Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19 Bioscience Reports, 2021-07-30;0(0):. 2021-07-30 [PMID: 34195785] (Human)
• Marie Vandestienne, Yujiao Zhang, Icia Santos-Zas, Rida Al-Rifai, Jeremie Joffre, Andreas Giraud et al. TREM-1 orchestrates angiotensin II–induced monocyte trafficking and promotes experimental abdominal aortic aneurysm Journal of Clinical Investigation 2021-01-19 [PMID: 33258804] (Human)
• W Chang, F Peng, SS Meng, JY Xu, Y Yang Diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis: a meta-analysis BMC Immunol., 2020-01-13;21(1):2. 2020-01-13 [PMID: 31931717] (Human)
• Y He, Q Yang, X Wang, A Jia, W Xie, J Zhou Inhibition of Triggering Receptor Expressed on Myeloid Cell-1 Alleviates Acute Gouty Inflammation Mediators Inflamm., 2019-12-06;2019(0):5647074. 2019-12-06 [PMID: 31885496] (Human)
• J Hyun, RS McMahon, AL Lang, JS Edwards, AD Badilla, ME Greene, GW Stone, S Pallikkuth, M Stevenson, DM Dykxhoorn, S Kottilil, S Pahwa, E Thomas HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells PLoS Pathog., 2019-07-01;15(7):e1007883. 2019-07-01 [PMID: 31260499] (Human)
• JY Feng, WJ Su, SW Pan, YC Yeh, YY Lin, NJ Chen Role of TREM-1 in pulmonary tuberculosis patients- analysis of serum soluble TREM-1 levels Sci Rep, 2018-05-29;8(1):8223. 2018-05-29 [PMID: 29844416] (Human)
• AA Arguinano, NC Ndiaye, C Masson, S Visvikis-S Pleiotropy of ABO gene: correlation of rs644234 with E-selectin and lipid levels Clin. Chem. Lab. Med., 2018-04-25;0(0):. 2018-04-25 [PMID: 29373315] (Human)
• AA Aldasoro A, S Dadé, M Stathopoul, M Derive, N Coumba Ndi, T Xie, C Masson, S Gibot, S Visvikis-S TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin PLoS ONE, 2017-08-03;12(8):e0182226. 2017-08-03 [PMID: 28771614] (Human)
• E Sierra-Dia, A Bravo Cuél, PC Ortiz Laza, M García Gut, HF Georgina, R Anaya Prad Urine TREM-1 as a marker of urinary tract infection in children J. Int. Med. Res., 2017-04-02;45(2):631-638. 2017-04-02 [PMID: 28367708] (Human)
• Chen CY, Yang KY, Chen MY, Chen HY, Lin MT, Lee YC, Perng RP, Hsieh SL, Yang PC, Chou TY Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med., 2009-07-30;180(8):751-60. 2009-07-30 [PMID: 19644047] (Human)
• Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis. Arthritis Rheum., 2009-06-01;60(6):1615-23. 2009-06-01 [PMID: 19479878] (Human)
• Park JJ, Cheon JH, Kim BY, Kim DH, Kim ES, Kim TI, Lee KR, Kim WH Correlation of serum-soluble triggering receptor expressed on myeloid cells-1 with clinical disease activity in inflammatory bowel disease. Dig. Dis. Sci., 2008-10-31;54(7):1525-31. 2008-10-31 [PMID: 18975078] (Human)
• Yasuda T, Takeyama Y, Ueda T, Shinzeki M, Sawa H, Takahiro N, Kamei K, Ku Y, Kuroda Y, Ohyanagi H Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis. Crit. Care Med., 2008-07-01;36(7):2048-53. 2008-07-01 [PMID: 18552693] (Human)
• Ho CC, Liao WY, Wang CY, Lu YH, Huang HY, Chen HY, Chan WK, Chen HW, Yang PC TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer. Am. J. Respir. Crit. Care Med., 2007-12-20;177(7):763-70. 2007-12-20 [PMID: 18096709] (Human)

FAQs for TREM1 (DTRM10C). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: TREM1