Human Total beta-Catenin DuoSet IC ELISA, 2 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Total beta-Catenin DuoSet IC ELISA, 2 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CTNNB1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Total beta-Catenin DuoSet IC ELISA, 2 Plate

• bCatenin
• beta 1 (88kD)
• beta-Catenin
• catenin (cadherin-associated protein), beta 1, 88kDa
• catenin beta-1
• CTNNB
• CTNNB1
• DKFZp686D02253
• FLJ25606
• FLJ37923

Background

beta-Catenin, also known as CTNNB1, is a cadherin-associated protein that is involved in the regulation of cell adhesion. This multifunctional protein is also implicated in the canonical Wnt signal transduction pathway, acting as a transcriptional co-activator. Nuclear beta-Catenin activates the TCF/LEF family of transcription factors, inducing the transcription of pro-mitotic genes.

Publications for beta-Catenin (DYC1329-2)(10)

Publications using DYC1329-2

• Al-Salam, S;Jagadeesh, GS;Sudhadevi, M;Yasin, J; Galectin-3 and Autophagy in Renal Acute Tubular Necrosis International journal of molecular sciences 2024-03-22 [PMID: 38612416] (Mouse, Transgenic Mouse)
• H Shailesh, KS Siveen, S Sif Protein arginine methyltransferase 5 (PRMT5) activates WNT/&beta-catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 Journal of Cellular and Molecular Medicine, 2021-01-18;0(0):. 2021-01-18 [PMID: 33462997] (Human)
• BH Clough, S Zeitouni, U Krause, CD Chaput, LM Cross, AK Gaharwar, CA Gregory Rapid Osteogenic Enhancement of Stem Cells in Human Bone Marrow Using a Glycogen-Synthease-Kinase-3-Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo Stem Cells Transl Med, 2018-02-05;0(0):. 2018-02-05 [PMID: 29405665] (Human)
• L Akbarzadeh, T Moini Zanj, M Sabetkasae Comparison of Anticancer Effects of Carbamazepine and Valproic Acid Iran Red Crescent Med J, 2016-08-04;18(10):e37230. 2016-08-04 [PMID: 28184324] (Human)
• Umbreit C, Flanjak J, Weiss C, Erben P, Aderhold C, Faber A, Stern-Straeter J, Hoermann K, Schultz J Incomplete epithelial-mesenchymal transition in p16-positive squamous cell carcinoma cells correlates with beta-catenin expression. Anticancer Res, 2014-12-01;34(12):7061-9. 2014-12-01 [PMID: 25503133] (Human)
• Takei Y, Takigahira M, Mihara K, Tarumi Y, Yanagihara K The Metastasis-Associated microRNA miR-516a-3p Is a Novel Therapeutic Target for Inhibiting Peritoneal Dissemination of Human Scirrhous Gastric Cancer. Cancer Res., 2010-12-17;71(4):1442-1453. 2010-12-17 [PMID: 21169410] (Human)
• Gunn WG, Krause U, Lee N, Gregory CA Pharmaceutical inhibition of glycogen synthetase kinase-3beta reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model. Blood, 2010-12-01;117(5):1641-51. 2010-12-01 [PMID: 21123822] (Mouse)
• Matushansky I, Hernando E, Socci ND, Mills JE, Matos TA, Edgar MA, Singer S, Maki RG, Cordon-Cardo C Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway. J. Clin. Invest., 2007-11-01;117(11):3248-57. 2007-11-01 [PMID: 17948129] (Human)
• Bhattacharyya S, Borthakur A, Dudeja PK, Tobacman JK Carrageenan reduces bone morphogenetic protein-4 (BMP4) and activates the Wnt/beta-catenin pathway in normal human colonocytes. Dig. Dis. Sci., 2007-04-12;52(10):2766-74. 2007-04-12 [PMID: 17429723] (Human)
• Dolled-Filhart M, McCabe A, Giltnane J, Cregger M, Camp RL, Rimm DL Quantitative in situ analysis of beta-catenin expression in breast cancer shows decreased expression is associated with poor outcome. Cancer Res., 2006-05-15;66(10):5487-94. 2006-05-15 [PMID: 16707478] (Human)

FAQs for beta-Catenin (DYC1329-2). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: CTNNB1