Hu, Mu, RtApplications:
WB, Simple Western, IHC, ChIP, CyTOF-ready, Flow, ICC/IFHost:
Hu, Mu, Rt, Ch, PmApplications:
WB, Simple Western, Flow, Flow-IC, ICC/IF, IHC, IHC-P, IPHost:
Hu, Mu, Rt, Po, Bv, Ca, Ch, RM, Sh, Xp, ZeApplications:
WB, Flow, ICC/IF, IHC, IHC-P, IP, PLA, ChIPHost:
WB, ELISA, PA, AP
Applications: WB, ELISA, PA, PAGE, AP
The protein encoded by the beta Catenin gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs arenecessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion betweencells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contactinhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this proteinbinds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this geneare a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Bioinformatics Tool for beta-Catenin
Discover related pathways, diseases and genes to beta-Catenin. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.
Related beta-Catenin Blog Posts
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