Human Endostatin Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human Endostatin Quantikine ELISA Kit Summary

Background
The Quantikine Human Endostatin Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human Endostatin in cell culture supernates, serum, plasma, and saliva. It contains E. coli-expressed recombinant human Endostatin and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Endostatin showed linear curves that were parallel to... the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring Endostatin.
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Specificity
Natural and recombinant human Endostatin
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
COL18A1

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DNST0.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Endostatin Quantikine ELISA Kit

  • antiangiogenic agent
  • COL18A1
  • collagen alpha-1(XVIII) chain
  • collagen, type XVIII, alpha 1
  • Endostatin
  • FLJ27325
  • FLJ34914
  • human type XVIII collagen10endostatin
  • KNO
  • KNO1MGC74745
  • Knobloch syndrome, type 1
  • KS
  • multi-functional protein MFP

Background

Endostatin is a 20 kDa proteolytic fragment of the C-terminal, non-collagenous (NC1) domain of type XVIII Collagen. It was originally identified as a factor produced by murine hemangioendothelioma cells that could specifically inhibit endothelial cell proliferation and angiogenesis. Although the molecular signals that trigger the release of Endostatin from type XVIII Collagen are not well understood, multiple proteases have been suggested to be involved in its generation including Cathepsins S, B, L, and V, Elastase, and matrix metalloproteinases (MMPs)-2, -7, and -9. Endostatin is of particular interest as it has been shown to inhibit the growth of many primary and metastatic tumors. It may also be involved in down-regulating angiogenesis during physiological processes such as wound healing and the establishment of placental circulation. The anti-angiogenic activity of Endostatin is attributable to its ability to inhibit endothelial cell proliferation and suppress VEGF-and FGF basic-induced endothelial cell migration and adhesion. Many of these effects are thought to be mediated by interactions between Endostatin and endothelial cell-expressed Transglutaminase 2, Heparin, and Integrins alpha 5 beta 1 and alpha V beta 3.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Endostatin (DNST0)(22)

We have publications tested in 3 confirmed species: Human, Mouse, Goat.


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Human
(20)
Mouse
(1)
Goat
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Showing Publications 1 - 10 of 22. Show All 22 Publications.
Publications using DNST0 Applications Species
FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk, Systemic Inflammation Precedes Microalbuminuria in Diabetes Kidney Int Rep, 2019;4(10):1373-1386. 2019 [PMID: 31701047] (Human) Human
YY Joo, JW Jang, SW Lee, SH Yoo, JH Kwon, SW Nam, SH Bae, JY Choi, SK Yoon Circulating pro- and anti-angiogenic factors in multi-stage liver disease and hepatocellular carcinoma progression Sci Rep, 2019;9(1):9137. 2019 [PMID: 31235729] (Human) Human
J Zhang, D Nie, K Williamson, JL Rocha, MV Hogan, JH Wang Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing J Tissue Eng, 2019;10(0):2.04173E+15. 2019 [PMID: 30728936] (Human) Human
M Holsti, A Wanhainen, C Lundin, M Björck, G Tegler, J Svensson, M Sund Circulating Vascular Basement Membrane Fragments are Associated with the Diameter of the Abdominal Aorta and Their Expression Pattern is Altered in AAA Tissue Eur J Vasc Endovasc Surg, 2018;0(0):. 2018 [PMID: 29656960] (Human) Human
Borghini A, Manetti M, Nacci F, Bellando-Randone S, Guiducci S, Matucci-Cerinic M, Ibba-Manneschi L, Weber E Systemic Sclerosis Sera Impair Angiogenic Performance of Dermal Microvascular Endothelial Cells: Therapeutic Implications of Cyclophosphamide. PLoS ONE, 2015;10(6):e0130166. 2015 [PMID: 26076019] (Human) Human
Marek-Trzonkowska N, Kwieczynska A, Reiwer-Gostomska M, Kolinski T, Molisz A, Siebert J Arterial Hypertension Is Characterized by Imbalance of Pro-Angiogenic versus Anti-Angiogenic Factors. PLoS ONE, 2015;10(5):e0126190. 2015 [PMID: 25951297] (Human) Human
Hutzen , Brian, Bid , Hemant K, Houghton , Peter J, Pierson , Christop, Powell , Kimerly, Bratasz , Anna, Raffel , Corey, Studebaker , Adam W Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin. BMC Cancer, 2014;14(0):206. 2014 [PMID: 24646176] (Human) Human
Sponder M, Dangl D, Kampf S, Fritzer-Szekeres M, Strametz-Juranek J Exercise increases serum endostatin levels in female and male patients with diabetes and controls. Cardiovasc Diabetol, 2014;13(0):6. 2014 [PMID: 24393402] (Human) Human
Battinelli , Elisabet, Markens , Beth A, Kulenthirarajan , Rajesh A, Machlus , Kellie R, Flaumenhaft , Robert, Italiano , Joseph E Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response. Blood, 2014;123(1):101-12. 2014 [PMID: 24065244] (Human) Human
Leifler K, Svensson S, Abrahamsson A, Bendrik C, Robertson J, Gauldie J, Olsson A, Dabrosin C Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer. J Immunol, 2013;190(8):4420-30. 2013 [PMID: 23509357] (Mouse) Mouse
Show All 22 Publications.

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Bioinformatics

Gene Symbol COL18A1