Human Endostatin Quantikine ELISA Kit

Images

 

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price

Human Endostatin Quantikine ELISA Kit Summary

Background
The Quantikine Human Endostatin Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human Endostatin in cell culture supernates, serum, plasma, and saliva. It contains E. coli-expressed recombinant human Endostatin and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Endostatin showed linear curves that were parallel to... the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring Endostatin.
Show More
Specificity
Natural and recombinant human Endostatin
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
COL18A1

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DNST0.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Endostatin Quantikine ELISA Kit

  • antiangiogenic agent
  • COL18A1
  • collagen alpha-1(XVIII) chain
  • collagen, type XVIII, alpha 1
  • Endostatin
  • FLJ27325
  • FLJ34914
  • human type XVIII collagen10endostatin
  • KNO
  • KNO1MGC74745
  • Knobloch syndrome, type 1
  • KS
  • multi-functional protein MFP

Background

Endostatin is a 20 kDa proteolytic fragment of the C-terminal, non-collagenous (NC1) domain of type XVIII Collagen. It was originally identified as a factor produced by murine hemangioendothelioma cells that could specifically inhibit endothelial cell proliferation and angiogenesis. Although the molecular signals that trigger the release of Endostatin from type XVIII Collagen are not well understood, multiple proteases have been suggested to be involved in its generation including Cathepsins S, B, L, and V, Elastase, and matrix metalloproteinases (MMPs)-2, -7, and -9. Endostatin is of particular interest as it has been shown to inhibit the growth of many primary and metastatic tumors. It may also be involved in down-regulating angiogenesis during physiological processes such as wound healing and the establishment of placental circulation. The anti-angiogenic activity of Endostatin is attributable to its ability to inhibit endothelial cell proliferation and suppress VEGF-and FGF basic-induced endothelial cell migration and adhesion. Many of these effects are thought to be mediated by interactions between Endostatin and endothelial cell-expressed Transglutaminase 2, Heparin, and Integrins alpha 5 beta 1 and alpha V beta 3.

Customers Who Viewed This Item Also Viewed...

NBP2-12897
Species: Hu, Mu, Rt, Ha
Applications: WB, ICC/IF, IHC, IHC-P, IP, MiAr
H00003753-M01
Species: Hu, Rt, Ca, Gp, Pm
Applications: WB, ELISA, ICC/IF, RNAi, S-ELISA
AF226
Species: Hu
Applications: WB
7270-IL/CF
Species: Hu
NBP1-19371
Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
NBP2-43648
Species: Hu, Mu, Rt, Ze
Applications: WB, ICC/IF, IHC, IHC-P
NBP2-80513
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
NBP2-29429
Species: Hu, Mu, Rt, Bv, Ca, Ch, Pm, Rb, Re, Ze
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, Dual ISH-IHC, Flow-IC, Single-Cell Western
NB100-74350
Species: Hu, Mu, Rt, Po, Bv, Ca
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
NB600-930
Species: Hu, Rt
Applications: WB, ELISA
MMP200
Species: Hu, Mu, Rt, Po, Ca
AF3628
Species: Mu, Rt
Applications: WB, Flow, IHC, CyTOF-ready, ICC
AF644
Species: Mu
Applications: WB, Flow, IHC, CyTOF-ready, Neut
NBP2-34260
Species: Hu, Mu, Po, Bv, Rb
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
NB110-41083
Species: Hu
Applications: WB, ChIP, ELISA, ICC/IF
DNST0
Species: Hu
Applications: ELISA
⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Endostatin (DNST0)(21)

We have publications tested in 3 confirmed species: Human, Mouse, Goat.


Filter By Application
All Applications
Filter By Species
Human
(19)
Mouse
(1)
Goat
(1)
All Species
Showing Publications 1 - 10 of 21. Show All 21 Publications.
Publications using DNST0 Applications Species
FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk, Systemic Inflammation Precedes Microalbuminuria in Diabetes Kidney Int Rep, 2019;4(10):1373-1386. 2019 [PMID: 31701047] (Human) Human
J Zhang, D Nie, K Williamson, JL Rocha, MV Hogan, JH Wang Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing J Tissue Eng, 2019;10(0):2.04173E+15. 2019 [PMID: 30728936] (Human) Human
M Holsti, A Wanhainen, C Lundin, M Björck, G Tegler, J Svensson, M Sund Circulating Vascular Basement Membrane Fragments are Associated with the Diameter of the Abdominal Aorta and Their Expression Pattern is Altered in AAA Tissue Eur J Vasc Endovasc Surg, 2018;0(0):. 2018 [PMID: 29656960] (Human) Human
Borghini A, Manetti M, Nacci F, Bellando-Randone S, Guiducci S, Matucci-Cerinic M, Ibba-Manneschi L, Weber E Systemic Sclerosis Sera Impair Angiogenic Performance of Dermal Microvascular Endothelial Cells: Therapeutic Implications of Cyclophosphamide. PLoS ONE, 2015;10(6):e0130166. 2015 [PMID: 26076019] (Human) Human
Marek-Trzonkowska N, Kwieczynska A, Reiwer-Gostomska M, Kolinski T, Molisz A, Siebert J Arterial Hypertension Is Characterized by Imbalance of Pro-Angiogenic versus Anti-Angiogenic Factors. PLoS ONE, 2015;10(5):e0126190. 2015 [PMID: 25951297] (Human) Human
Hutzen, Brian, Bid, Hemant K, Houghton, Peter J, Pierson, Christop, Powell, Kimerly, Bratasz, Anna, Raffel, Corey, Studebaker, Adam W Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin. BMC Cancer, 2014;14(0):206. 2014 [PMID: 24646176] (Human) Human
Sponder M, Dangl D, Kampf S, Fritzer-Szekeres M, Strametz-Juranek J Exercise increases serum endostatin levels in female and male patients with diabetes and controls. Cardiovasc Diabetol, 2014;13(0):6. 2014 [PMID: 24393402] (Human) Human
Battinelli, Elisabet, Markens, Beth A, Kulenthirarajan, Rajesh A, Machlus, Kellie R, Flaumenhaft, Robert, Italiano, Joseph E Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response. Blood, 2014;123(1):101-12. 2014 [PMID: 24065244] (Human) Human
Leifler K, Svensson S, Abrahamsson A, Bendrik C, Robertson J, Gauldie J, Olsson A, Dabrosin C Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer. J Immunol, 2013;190(8):4420-30. 2013 [PMID: 23509357] (Mouse) Mouse
Zheng, Lan, Zhang, Dongmei, Chen, Xianchen, Yang, Li, Wei, Yuquan, Zhao, Xia Antitumor activities of human placenta-derived mesenchymal stem cells expressing endostatin on ovarian cancer. PLoS ONE, 2012;7(7):e39119. 2012 [PMID: 22911684] (Human) Human
Show All 21 Publications.

Reviews for Endostatin (DNST0) (0)

There are no reviews for Endostatin (DNST0). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Endostatin (DNST0). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.
Coronavirus Brochure

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Review this Product

Be the first to review our Human Endostatin Quantikine ELISA Kit and receive a gift card or discount.

Bioinformatics

Gene Symbol COL18A1