Human RAGE DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human RAGE DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: AGER

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human RAGE DuoSet ELISA, 15 Plate

• advanced glycosylation end product-specific receptor
• AGER
• RAGE isoform delta
• RAGE isoform sRAGE-delta
• RAGE
• Receptor for advanced glycosylation end products
• receptor for advanced glycosylation end-products
• SCARJ1

Background

RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.

To view our complete solutions for RAGE research, visit bio-techne.com.

Publications for AGER (DY1145)(28)

Publications using DY1145

• Vettoretti, S;Caldiroli, L;Molinari, P;Villa, A;Corsi Romanelli, MM;Vianello, E;Dozio, E;Genovesi, S; Exploring the Interplay Between Glycated Albumin, AGEs, and Inflammation in Old Patients with CKD Metabolites 2025-08-01 [PMID: 40863134] (Human)
• Rambaud, V;Frajerman, A;Fournier, M;Iftimovici, A;Dwir, D;Khadimallah, I;Kebir, O;Marzo, A;Krebs, MO;Chaumette, B; Oxidative stress markers during the psychotic transition Journal of psychiatric research 2025-04-03 [PMID: 40239390] (Human)
• Kanikowska, D;Kanikowska, A;Strojny, Z;Kawka, E;Zawada, A;Rutkowski, R;Litwinowicz, M;Sato, M;Grzymis?awski, M;Br?borowicz, A;Witowski, J;Korybalska, K; Assessment of EN-RAGE, sRAGE, and its isoforms: cRAGE, esRAGE in obese patients treated by moderate caloric restriction combined with physical activity conducted in hospital condition Cytokine 2024-05-31 [PMID: 38823153] (Human)
• Tsoporis, JN;Triantafyllis, AS;Kalogeropoulos, AS;Izhar, S;Rigopoulos, AG;Rallidis, LS;Sakadakis, E;Toumpoulis, IK;Salpeas, V;Leong-Poi, H;Parker, TG;Rizos, I; Differential Expression of Circulating Damage-Associated Molecular Patterns in Patients with Coronary Artery Ectasia Biomolecules 2023-12-21 [PMID: 38275751] (Human)
• Xiong, Y;Wang, B;Jiao, J;Tang, M;Li, K;Jiang, R;Huang, W; Expression and clinical association of MFG-E8 and TAM receptors in diabetic patients with different stages of microvascular complication: An experimental study Medicine 2023-11-03 [PMID: 37933040] (Human)
• Warren, KJ;Beck, EM;Callahan, SJ;Helms, MN;Middleton, E;Maddock, S;Carr, JR;Harris, D;Blagev, DP;Lanspa, MJ;Brown, SM;Paine, R; Alveolar macrophages from EVALI patients and e-cigarette users: a story of shifting phenotype Respiratory research 2023-06-17 [PMID: 37330506] (Human)
• S Helleputte, P Calders, A Rodenbach, J Marlier, C Verroken, T De Backer, B Lapauw Time-varying parameters of glycemic control and glycation in relation to arterial stiffness in patients with type 1 diabetes Cardiovascular Diabetology, 2022-12-09;21(1):277. 2022-12-09 [PMID: 36494687] (Human)
• J Sabbatinel, S Castiglion, F Macrì, A Giuliani, D Ramini, MC Vinci, E Tortato, AR Bonfigli, F Olivieri, A Raucci Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study Cardiovascular Diabetology, 2022-06-06;21(1):95. 2022-06-06 [PMID: 35668468] (Human)
• KN Lee, KH Park, YM Kim, I Cho, TE Kim Prediction of emergency cerclage outcomes in women with cervical insufficiency: The role of inflammatory, angiogenic, and extracellular matrix-related proteins in amniotic fluid PLoS ONE, 2022-05-10;17(5):e0268291. 2022-05-10 [PMID: 35536791] (Human)
• J Villar, R Herrán-Mon, E González-H, M Prieto-Gon, A Ambrós, A Rodríguez-, A Muriel-Bom, R Solano, C Cuenca-Rub, A Vidal, C Flores, JM González-M, MI García-Lao, Genetics o Clinical and biological markers for predicting ARDS and outcome in septic patients Scientific Reports, 2021-11-22;11(1):22702. 2021-11-22 [PMID: 34811434] (Human)
• F Scavello, F Zeni, G Milano, F Macrì, S Castiglion, E Zuccolo, A Scopece, G Pezone, CC Tedesco, P Nigro, G Degani, E Gambini, F Veglia, L Popolo, G Pompilio, GI Colombo, ME Bianchi, A Raucci Soluble Receptor for Advanced Glycation End-products regulates age-associated Cardiac Fibrosis International journal of biological sciences, 2021-06-11;17(10):2399-2416. 2021-06-11 [PMID: 34326683] (Human)
• KA Pratte, JL Curtis, K Kechris, D Couper, MH Cho, EK Silverman, DL DeMeo, FC Sciurba, Y Zhang, VE Ortega, WK O'Neal, LA Gillenwate, DA Lynch, EA Hoffman, JD Newell, AP Comellas, PJ Castaldi, BE Miller, SD Pouwels, NHTT Hacken, R Bischoff, F Klont, PG Woodruff, R Paine, RG Barr, J Hoidal, CM Doerschuk, JP Charbonnie, R Sung, N Locantore, JG Yonchuk, S Jacobson, R Tal-Singer, D Merrill, RP Bowler Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD Respiratory Research, 2021-04-27;22(1):127. 2021-04-27 [PMID: 33906653] (Human)
• E Dozio, S Vettoretti, L Caldiroli, S Nerini-Mol, L Tacchini, F Ambrogi, P Messa, MM Corsi Roma Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKD Biomedicines, 2020-12-21;8(12):. 2020-12-21 [PMID: 33371369] (Human)
• E Dozio, C Sitzia, L Pistelli, R Cardani, R Rigolini, M Ranucci, MM Corsi Roma Soluble Receptor for Advanced Glycation End Products and Its Forms in COVID-19 Patients with and without Diabetes Mellitus: A Pilot Study on Their Role as Disease Biomarkers J Clin Med, 2020-11-23;9(11):. 2020-11-23 [PMID: 33238596] (Human)
• JN Tsoporis, E Hatziagela, S Gupta, S Izhar, V Salpeas, A Tsiavou, AG Rigopoulos, AS Triantafyl, JC Marshall, TG Parker, IK Rizos Circulating Ligands of the Receptor for Advanced Glycation End Products and the Soluble Form of the Receptor Modulate Cardiovascular Cell Apoptosis in Diabetes Molecules, 2020-11-10;25(22):. 2020-11-10 [PMID: 33182705] (Human)
• EO Melin, J Dereke, M Hillman Higher levels of the soluble receptor for advanced glycation end products and lower levels of the extracellular newly identified receptor for advanced glycation end products were associated with lipid-lowering drugs in patients with type 1 diabetes: a comparative cross-sectional study Lipids Health Dis, 2020-10-14;19(1):223. 2020-10-14 [PMID: 33054750] (Human)
• AK Fotheringh, JI Bagger, DJ Borg, DA McCarthy, JJ Holst, T Vilsbøll, FK Knop, JM Forbes Circulating Levels of the Soluble Receptor for AGE (sRAGE) during Escalating Oral Glucose Dosages and Corresponding Isoglycaemic i.v. Glucose Infusions in Individuals with and without Type 2 Diabetes Nutrients, 2020-09-24;12(10):. 2020-09-24 [PMID: 32987824] (Human)
• E Dozio, E Vianello, C Sitzia, F Ambrogi, S Benedini, S Gorini, B Rampoldi, R Rigolini, L Tacchini, MMC Romanelli Circulating Irisin and esRAGE as Early Biomarkers of Decline of Metabolic Health J Clin Med, 2020-02-06;9(2):. 2020-02-06 [PMID: 32041319] (Human)
• E Galliera, L Massaccesi, E de Benedet, E Longhi, D de Toma, MM Corsi Roma, G Banfi Longitudinal evaluation of Wnt inhibitors and comparison with others serum osteoimmunological biomarkers in osteolytic bone metastasis J. Leukoc. Biol., 2020-02-07;0(0):. 2020-02-07 [PMID: 32034807] (Human)
• F Scavello, F Zeni, CC Tedesco, E Mensà, F Veglia, AD Procopio, AR Bonfigli, F Olivieri, A Raucci Modulation of soluble receptor for advanced glycation end-products (RAGE) isoforms and their ligands in healthy aging Aging (Albany NY), 2019-03-23;11(6):1648-1663. 2019-03-23 [PMID: 30903794] (Human, Rat)
• A Braley, T Kwak, J Jules, E Harja, R Landgraf, BI Hudson Regulation of RAGE ectodomain shedding and its role in cell function J Biol Chem, 2016-03-28;0(0):. 2016-03-28 [PMID: 27022018] (Human)
• Moser B, Janik S, Schiefer A, Mullauer L, Bekos C, Scharrer A, Mildner M, Renyi-Vamos F, Klepetko W, Ankersmit H Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology. PLoS ONE, 2014-04-04;9(4):e94118. 2014-04-04 [PMID: 24705787] (Human)
• Palombo C, Kozakova M, Morizzo C, Gnesi L, Barsotti M, Spontoni P, Massart F, Salvi P, Balbarini A, Saggese G, Di Stefano R, Federico G Circulating endothelial progenitor cells and large artery structure and function in young subjects with uncomplicated type 1 diabetes. Cardiovasc Diabetol, 2011-10-08;10(0):88. 2011-10-08 [PMID: 21981808] (Human)
• Basta G, Corciu AI, Vianello A, Del Turco S, Foffa I, Navarra T, Chiappino D, Berti S, Mazzone A Circulating soluble receptor for advanced glycation end-product levels are decreased in patients with calcific aortic valve stenosis. Atherosclerosis, 2010-01-04;210(2):614-8. 2010-01-04 [PMID: 20074734] (Human)
• Basta G, Castagnini M, Del Turco S, Epistolato MC, Righini P, Sangiorgi GM, De Caterina R, Tanganelli P High plasma levels of the soluble receptor for advanced glycation endproducts in patients with symptomatic carotid atherosclerosis. Eur. J. Clin. Invest., 2009-10-07;39(12):1065-72. 2009-10-07 [PMID: 19811526] (Human)
• Hsu HY, Wittemann S, Schneider EM, Weiss M, Joos TO Suspension microarrays for the identification of the response patterns in hyperinflammatory diseases. Med Eng Phys, 2008-03-03;30(8):976-83. 2008-03-03 [PMID: 18313970] (Human)
• Determann RM, Wolthuis EK, Choi G, Bresser P, Bernard A, Lutter R, Schultz MJ Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-12-14;294(2):L344-50. 2007-12-14 [PMID: 18083770] (Human)
• Mallidis C, Agbaje I, Rogers D, Glenn J, McCullough S, Atkinson AB, Steger K, Stitt A, McClure N Distribution of the receptor for advanced glycation end products in the human male reproductive tract: prevalence in men with diabetes mellitus. Hum. Reprod., 2007-06-21;22(8):2169-77. 2007-06-21 [PMID: 17588956] (Human)

FAQs for AGER (DY1145). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: AGER