Human Pappalysin-1/PAPP-A Quantikine ELISA Kit Summary
Background
The Quantikine Human PAPP-A Immunoassay is a 5.5 hour sandwich-type solid phase ELISA designed to measure human PAPP-A in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human PAPP-A and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human PAPP-A showed linear curves that were parallel to the standard curves ob...tained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring PAPP-A.
Insulin-like growth factor-dependent IGF-binding protein 4 protease
PAPA
PAPPA
PAPPA1
PAPP-A1
PAPP-Adifferentially placenta 1 expressed protein
Pappalysin1
Pappalysin-1
pregnacy-associated plasma protein A
Pregnancy-associated plasma protein A
pregnancy-associated plasma protein A, pappalysin 1
Background
Pappalysins comprise one of the five families of Metzincins (other families include ADAMs/ADAMTSs, MMPs, Astacins, and Serralysins). Pappalysin-1 (PAPP-A) is an important pregnancy protein and increases in plasma by a factor of about 150 during pregnancy. Reduced maternal serum PAPP-A is a major marker of Down syndrome in the first trimester of pregnancy. PAPP-A cleaves IGFBP-4 and -5 (insulin-like growth factor-binding protein-4 and 5) at a single site, resulting in the release of bioactive IGF. Pappalysin-2 (PAPP-A2; also called PAPP-E) shares 45% amino acid identity with PAPP-A and cleaves IGFBP-2.
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Publications for Pappalysin-1/PAPP-A (DPPA00)(4)
We have publications tested in 1 confirmed species: Human.
FAQs for Pappalysin-1/PAPP-A (DPPA00). (Showing 1 - 1 of 1 FAQs).
I am highly interested to use couple of Anti-PAPP-A antibodies from your reputed companies for my research work. I have got the information regarding the immunogen used to generate these antibodies, however could not get any information regarding the specific amino acids/epitope to which your Anti-PAPP-A Antibodies binds with the antigen (PAPP-A).
Unfortunately, none of our PAPP A antibodies have been epitope mapped. Many of them have also been generated against full-length PAPP A, so there are many potential binding sites.
Bioinformatics Tool for Pappalysin-1/PAPP-A (DPPA00)
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Diseases for Pappalysin-1/PAPP-A (DPPA00)
Discover more about diseases related to Pappalysin-1/PAPP-A (DPPA00).