Human MIF DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human MIF DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: MIF

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human MIF DuoSet ELISA, 15 Plate

• EC 5.3.2.1
• EC 5.3.3.12
• GIFmacrophage migration inhibitory factor
• GLIF
• Glycosylation-inhibiting factor
• L-dopachrome isomerase
• L-dopachrome tautomerase
• macrophage migration inhibitory factor (glycosylation-inhibiting factor)
• MIF
• MMIF
• Phenylpyruvate tautomerase

Background

MIF (macrophage migration inhibitory factor) is a pro-inflammatory cytokine that is released during microbial infection, ARDS, rheumatoid arthritis, atherosclerosis, type 2 diabetes, and cancer. It signals through CXCR4, CXCR7, or complexes of CD74-CD44. MIF exhibits potent paracrine and autocrine stimulatory effects on cell growth and survival and enhances the production of inflammatory cytokines. It also inhibits the effectiveness of immunosuppressive glucocorticoids.

Publications for MIF (DY289)(32)

Publications using DY289

• J Toldi, L Kelava, S Marton, D Muhl, P Kustan, Z Feher, K Maar, J Garai, E Pakai, A Garami Distinct patterns of serum and urine macrophage migration inhibitory factor kinetics predict death in sepsis: a prospective, observational clinical study Scientific Reports, 2023-01-11;13(1):588. 2023-01-11 [PMID: 36631486] (Human)
• C Swoboda, L Deloch, C von Zimmer, T Richter-Sc, B Lenz, J Kornhuber, C Mühle Macrophage Migration Inhibitory Factor in Major Depressive Disorder: A Multilevel Pilot Study International Journal of Molecular Sciences, 2022-12-07;23(24):. 2022-12-07 [PMID: 36555097] (Human)
• K Nickel, U Wensorra, H Wenck, N Peters, H Genth Evaluation of Immunomodulatory Responses and Changed Wound Healing in Type 2 Diabetes-A Study Exploiting Dermal Fibroblasts from Diabetic and Non-Diabetic Human Donors Cells, 2021-10-28;10(11):. 2021-10-28 [PMID: 34831154] (Human)
• GR Ferreira, JR Santos-Oli, ML Silva-Frei, M Honda, DL Costa, AM Da-Cruz, CHN Costa Biomarkers of disease severity in patients with visceral leishmaniasis co-infected with HIV Cytokine, 2021-10-27;149(0):155747. 2021-10-27 [PMID: 34715475] (Human)
• MPO Almeida, CM Mota, TWP Mineo, EAV Ferro, BF Barbosa, NM Silva Heme Oxygenase-1 Induction in Human BeWo Trophoblast Cells Decreases Toxoplasma gondii Proliferation in Association With the Upregulation of p38 MAPK Phosphorylation and IL-6 Production Frontiers in Microbiology, 2021-04-12;12(0):659028. 2021-04-12 [PMID: 33912151] (Human)
• Y Chen, WK Wong, JC Seneviratn, S Huang, C McGrath, U Hagg Associations between salivary cytokines and periodontal and microbiological parameters in orthodontic patients Medicine, 2021-03-12;100(10):e24924. 2021-03-12 [PMID: 33725852] (Human)
• M Liu, Z Xie, G Sun, L Chen, D Qi, H Zhang, J Xiong, A Furey, P Rahman, G Lei, G Zhai Macrophage migration inhibitory factor may play a protective role in osteoarthritis Arthritis Research & Therapy, 2021-02-20;23(1):59. 2021-02-20 [PMID: 33610191] (Human)
• J Wang, X Lv, X Guo, Y Dong, P Peng, F Huang, P Wang, H Zhang, J Zhou, Y Wang, B Wei, ZF Shang, S Li Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells Oncogenesis, 2021-01-05;10(1):8. 2021-01-05 [PMID: 33431808]
• SC Teixeira, G de Souza, BC Borges, TE de Araújo, AM Rosini, FA Aguila, SR Ambrósio, RCS Veneziani, JK Bastos, MJB Silva, CHG Martins, B de Freitas, EAV Ferro Copaifera spp. oleoresins impair Toxoplasma gondii infection in both human trophoblastic cells and human placental explants Scientific Reports, 2020-09-16;10(1):15158. 2020-09-16 [PMID: 32938966] (Human)
• PS Franco, PSG Gois, TE de Araújo, RJ da Silva, B de Freitas, A de Oliveir, F Ietta, LA Dos Santos, MC Dos Santos, JR Mineo, EAV Ferro Brazilian strains of Toxoplasma gondii are controlled by azithromycin and modulate cytokine production in human placental explants J. Biomed. Sci., 2019-01-21;26(1):10. 2019-01-21 [PMID: 30665403] (Human)
• N Kindt, G Descamps, JR Lechien, M Remmelink, JM Colet, R Wattiez, G Berchem, F Journe, S Saussez Involvement of HPV Infection in the Release of Macrophage Migration Inhibitory Factor in Head and Neck Squamous Cell Carcinoma J Clin Med, 2019-01-10;8(1):. 2019-01-10 [PMID: 30634708] (Human)
• JA Fraser, S Kemp, L Young, M Ross, M Prach, GR Hutchison, E Malone Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations Sci Rep, 2018-05-14;8(1):7506. 2018-05-14 [PMID: 29760395] (Human)
• CM Henry, SJ Martin Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory FADDosome Complex upon TRAIL Stimulation Mol. Cell, 2017-02-16;65(4):715-729.e5. 2017-02-16 [PMID: 28212752] (Human)
• Ewa Kontny Secretory activity of subcutaneous abdominal adipose tissue in male patients with rheumatoid arthritis and osteoarthritis - association with clinical and laboratory data Reumatologia, 2016-11-28;54(5):227-235. 2016-11-28 [PMID: 27994266] (Human)
• Lee H, Kim B, Kim B, Kook Y, Kim B The development of a novel Mycobacterium-Escherichia coli shuttle vector system using pMyong2, a linear plasmid from Mycobacterium yongonense DSM 45126T. PLoS ONE, 2015-03-30;30(0):. 2015-03-30 [PMID: 25822634] (Bacteria - Mycobacterium smegmatis)
• Richard V, Kindt N, Decaestecker C, Gabius H, Laurent G, Noel J, Saussez S Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer. Oncol Rep, 2014-06-16;32(2):523-9. 2014-06-16 [PMID: 24939415] (Human)
• Reiners K, Kessler J, Sauer M, Rothe A, Hansen H, Reusch U, Hucke C, Kohl U, Durkop H, Engert A, von Strandmann E Rescue of impaired NK cell activity in hodgkin lymphoma with bispecific antibodies in vitro and in patients. Mol Ther, 2013-03-05;21(4):895-903. 2013-03-05 [PMID: 23459515] (Human)
• Cutrullis R, Petray P, Schapachnik E, Sanchez R, Postan M, Gonzalez M, Martin V, Corral R Elevated serum levels of macrophage migration inhibitory factor are associated with progressive chronic cardiomyopathy in patients with Chagas disease. PLoS ONE, 2013-02-22;8(2):e57181. 2013-02-22 [PMID: 23451183] (Human)
• Santos-Oliveira JR, Regis EG, Leal CR, Cunha RV, Bozza PT, Da-Cruz AM Evidence that lipopolisaccharide may contribute to the cytokine storm and cellular activation in patients with visceral leishmaniasis. PLoS Negl Trop Dis, 2011-07-12;5(7):e1198. 2011-07-12 [PMID: 21765960] (Human)
• de Oliveira Gomes A, de Oliveira Silva DA, Silva NM, de Freitas Barbosa B, Franco PS, Angeloni MB, Fermino ML, Roque-Barreira MC, Bechi N, Paulesu LR, Dos Santos MC, Mineo JR, Ferro EA Effect of macrophage migration inhibitory factor (MIF) in human placental explants infected with Toxoplasma gondii depends on gestational age. Am. J. Pathol., 2011-06-01;178(6):2792-801. 2011-06-01 [PMID: 21641401] (Human)
• Meyer-Siegler KL, Cox J, Leng L, Bucala R, Vera PL Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation. Cancer Lett., 2009-09-16;290(1):49-57. 2009-09-16 [PMID: 19762145] (Human)
• Dagia NM, Kamath DV, Bhatt P, Gupte RD, Dadarkar SS, Fonseca L, Agarwal G, Chetrapal-Kunwar A, Balachandran S, Srinivasan S, Bose J, Pari K, B-Rao C, Parkale SS, Gadekar PK, Rodge AH, Mandrekar N, Vishwakarma RA, Sharma S A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis. Eur. J. Pharmacol., 2009-02-21;607(1):201-12. 2009-02-21 [PMID: 19239912] (Human)
• Kim JY, Kwok SK, Hur KH, Kim HJ, Kim NS, Yoo SA, Kim WU, Cho CS Up-regulated macrophage migration inhibitory factor protects apoptosis of dermal fibroblasts in patients with systemic sclerosis. Clin. Exp. Immunol., 2008-03-18;152(2):328-35. 2008-03-18 [PMID: 18355352] (Human)
• Hsu HY, Wittemann S, Schneider EM, Weiss M, Joos TO Suspension microarrays for the identification of the response patterns in hyperinflammatory diseases. Med Eng Phys, 2008-03-03;30(8):976-83. 2008-03-03 [PMID: 18313970] (Human)
• Harding G, Mak YT, Evans B, Cheung J, MacDonald D, Hampson G The effects of dexamethasone and dehydroepiandrosterone (DHEA) on cytokines and receptor expression in a human osteoblastic cell line: potential steroid-sparing role for DHEA. Cytokine, 2006-12-11;36(1):57-68. 2006-12-11 [PMID: 17161616] (Human)
• Gomes RN, Bozza FA, Amancio RT, Japiassu AM, Vianna RC, Larangeira AP, Gouvea JM, Bastos MS, Zimmerman GA, Stafforini DM, Prescott SM, Bozza PT, Castro-Faria-Neto HC Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. Shock, 2006-07-01;26(1):41-9. 2006-07-01 [PMID: 16783197] (Mouse)
• Alourfi Z, Donn RP, Stevens A, Berry A, McMaster A, Ray DW Glucocorticoids suppress macrophage migration inhibitory factor (MIF) expression in a cell-type-specific manner. J. Mol. Endocrinol., 2005-04-01;34(2):583-95. 2005-04-01 [PMID: 15821118] (Human)
• Donn R, Alourfi Z, Zeggini E, Lamb R, Jury F, Lunt M, Meazza C, De Benedetti F, Thomson W, Ray D, Ray D A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis. Arthritis Rheum., 2004-05-01;50(5):1604-10. 2004-05-01 [PMID: 15146431] (Human)
• Chaiyaroj SC, Rutta AS, Muenthaisong K, Watkins P, Na Ubol M, Looareesuwan S Reduced levels of transforming growth factor-beta1, interleukin-12 and increased migration inhibitory factor are associated with severe malaria. Acta Trop., 2004-02-01;89(3):319-27. 2004-02-01 [PMID: 14744558] (Human)
• Ren Y, Poon RT, Tsui HT, Chen WH, Li Z, Lau C, Yu WC, Fan ST Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis. Clin. Cancer Res., 2003-12-01;9(16):5996-6001. 2003-12-01 [PMID: 14676125] (Human)
• Nguyen MT, Lue H, Kleemann R, Thiele M, Tolle G, Finkelmeier D, Wagner E, Braun A, Bernhagen J The cytokine macrophage migration inhibitory factor reduces pro-oxidative stress-induced apoptosis. J. Immunol., 2003-03-15;170(6):3337-47. 2003-03-15 [PMID: 12626594] (Human)
• Brown FG, Nikolic-Paterson DJ, Hill PA, Isbel NM, Dowling J, Metz CM, Atkins RC Urine macrophage migration inhibitory factor reflects the severity of renal injury in human glomerulonephritis. J. Am. Soc. Nephrol., 2002-01-01;13(0):S7-13. 2002-01-01 [PMID: 11792756] (Human)

Bioinformatics

• Gene Symbol: MIF