Store the unopened product at 2 - 8 °C. Do not use past expiration date.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Human LIGHT/TNFSF14 DuoSet ELISA, 15 Plate
delta transmembrane LIGHT
Herpes virus entry mediator ligand
Herpesvirus entry mediator ligand
HVEMLherpesvirus entry mediator-ligand
ligand for herpesvirus entry mediator
LIGHTherpesvirus entry mediator A
tumor necrosis factor (ligand) superfamily, member 14
tumor necrosis factor ligand superfamily member 14
tumor necrosis factor receptor-like 2
tumor necrosis factor superfamily member LIGHT
LIGHT, also known as TNFSF14, is a homotrimeric glycoprotein in the TNF superfamily. It is expressed on the surface of activated lymphocytes, NK cells, immature dendritic cells, monocytes, and granulocytes. A soluble form can be shed by proteolysis. LIGHT binds and activates HVEM/TNFRSF14 to costimulate Th1 immune responses, enhance CD8+ T cell mediated tumor immunity, and regulate allogeneic T cell activation and allograft rejection. In addition, it binds and activates Lymphotoxin beta R/TNFRSF3 to induce apoptosis, cytokine production, mesenteric lymph node organogenesis, and maintenance of lymph node structure and function. It can also bind the soluble human decoy receptor DcR3/TNFRSF6B.