Human Klotho DuoSet ELISA, 5 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Klotho DuoSet ELISA, 5 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: KL

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Klotho DuoSet ELISA, 5 Plate

• EC 3.2.1
• EC 3.2.1.31
• KL
• Klotho

Background

The Klotho proteins, Klotho and Klotho beta (beta KL), are type I transmembrane glycoproteins with extracellular regions that contain two beta-glycosidase-like repeats. Klotho has both membrane-bound and soluble forms; the soluble form predominates and consists of only the first beta-glycosidase-like repeat. Klotho has beta-glucuronidase activity against select steroid beta-glucuronides, appears to regulate calcium and vitamin D levels in serum, and is associated with premature aging.

Klotho beta, a divergent structural member of the glycosidase I superfamily, is primarily expressed in the liver and pancreas, with lower expression in adipose tissue. Klotho beta mediates the interaction of FGF-15 (human FGF-19) with FGF Receptor 4 in the liver, which negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes. Klotho beta is also a cofactor for the interaction of FGF-21 with FGF Receptor 1c in adipocytes. The expression pattern of Klotho beta suggests it may play a role in lipid metabolism.

Publications for Klotho (DY5334-05)(6)

Publications using DY5334-05

• M Yeganeh-Ha, H Najafipour, F Rostamzade, A Naghibzade Klotho and SIRT1 changes from pre-diabetes to diabetes and pre-hypertension to hypertension Diabetology & metabolic syndrome, 2021;13(1):115. 2021 [PMID: 34670596] (Human)
• MAR Brandao-Ra, R Moraes-Fer, MC Oliveira-J, A Santos-Dia, ALL Bachi, G Gabriela-P, S de Oliveir, AC Araújo-Ros, LVF Oliveira, CR Frison, WL do Prado, RP Raju, PB Balagopal, RP Vieira Pulmonary function changes in older adults with and without metabolic syndrome Scientific Reports, 2021;11(1):17337. 2021 [PMID: 34462482] (Human)
• WY Liang, LH Wang, JH Wei, QL Li, QY Li, Q Liang, NQ Hu, LH Li No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population Scientific Reports, 2021;11(1):2374. 2021 [PMID: 33504927] (Human)
• A Farías-Bas, HR Martínez-R, EF Gómez-Garc, AM Cueto-Manz, L Cortés-San, LE Hernández-, G Ramírez-Ló, F Mendoza-Ca Circulating Levels of Soluble Klotho and Fibroblast Growth Factor 23 in Mexican Diabetic Patients and Its Association With Early Nephropathy Arch. Med. Res., 2019;0(0):. 2019 [PMID: 30718148] (Human)
• A Chen, Y Sun, J Cui, B Zhao, H Wang, X Chen, Y Mao Associations of sclerostin with carotid artery atherosclerosis and all-cause mortality in Chinese patients undergoing maintenance hemodialysis BMC Nephrol, 2018;19(1):264. 2018 [PMID: 30314461] (Human)
• Almroth G, Lonn J, Uhlin F, Brudin L, Andersson B, Hahn-Zoric M Sclerostin, TNF-alpha and Interleukin-18 Correlate and are Together with Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients. Scand J Immunol, 2015;83(1):58-63. 2015 [PMID: 26448366] (Human)

FAQs for Klotho (DY5334-05). (Showing 1 - 1 of 1 FAQs).

1. I study physiology (PhD) and I need a klotho kit.
   • A list of our klotho products can be found here. I am not entirely sure what you are looking for as I don't have your complete message for some reason. Can you please clarify what you are looking for?

Bioinformatics

• Gene Symbol: KL