Human Klotho DuoSet ELISA, 5 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Klotho DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: KL

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Klotho DuoSet ELISA, 5 Plate

• EC 3.2.1
• EC 3.2.1.31
• KL
• Klotho

Background

The Klotho proteins, Klotho and Klotho beta (beta KL), are type I transmembrane glycoproteins with extracellular regions that contain two beta-glycosidase-like repeats. Klotho has both membrane-bound and soluble forms; the soluble form predominates and consists of only the first beta-glycosidase-like repeat. Klotho has beta-glucuronidase activity against select steroid beta-glucuronides, appears to regulate calcium and vitamin D levels in serum, and is associated with premature aging.

Klotho beta, a divergent structural member of the glycosidase I superfamily, is primarily expressed in the liver and pancreas, with lower expression in adipose tissue. Klotho beta mediates the interaction of FGF-15 (human FGF-19) with FGF Receptor 4 in the liver, which negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes. Klotho beta is also a cofactor for the interaction of FGF-21 with FGF Receptor 1c in adipocytes. The expression pattern of Klotho beta suggests it may play a role in lipid metabolism.

Publications for Klotho (DY5334-05)(13)

Publications using DY5334-05

• Moura-Maia, MS;Brill, B;Paula-Vieira, RHR;Ramos-Gomes, NV;Melamed, D;Silva-Reis, A;Wolpp, ETR;Moreira-Silva, NN;Bella, YF;Vieira, RP; Low Caloric Intake Confers Cardiovascular Protection and Improves Functional Capacity Without Affecting Immunological Response in Sedentary Older Adults Nutrients 2024-10-29 [PMID: 39519510] (Human)
• Pei, Y;Huang, W;Cao, L;Yang, F;Chi, C;Zhu, J; Serum Klotho Is Elevated in Patients with Acute Myocardial Infarction and Could Predict Poor In-Hospital Prognosis Journal of cardiovascular development and disease 2024-09-20 [PMID: 39330350] (Human)
• Barbu, E;Mihaila, AC;Gan, AM;Ciortan, L;Macarie, RD;Tucureanu, MM;Filippi, A;Stoenescu, AI;Petrea, SV;Simionescu, M;Balanescu, SM;Butoi, E; The Elevated Inflammatory Status of Neutrophils Is Related to In-Hospital Complications in Patients with Acute Coronary Syndrome and Has Important Prognosis Value for Diabetic Patients International journal of molecular sciences 2024-05-08 [PMID: 38791147] (Human)
• Chen, MH;Lin, WC;Li, CT;Wu, HJ;Bai, YM;Tsai, SJ;Su, TP;Tu, PC; Effects of low-dose ketamine infusion on vascular endothelial growth factor and matrix metalloproteinase-9 among patients with treatment-resistant depression and suicidal ideation Journal of psychiatric research 2023-07-19 [PMID: 37487293] (Human)
• D Aczel, F Torma, M Jokai, K McGreevy, A Boros, Y Seki, I Boldogh, S Horvath, Z Radak The Circulating Level of Klotho Is Not Dependent upon Physical Fitness and Age-Associated Methylation Increases at the Promoter Region of the Klotho Gene Genes, 2023-02-19;14(2):. 2023-02-19 [PMID: 36833453] (Human)
• Y Lin, J Huang, M Zhou, C Pan, A Shan, C Zhou Association of serum klotho levels with different-staged vascular calcification status in patients with maintenance hemodialysis Bmc Nephrology, 2022-11-19;23(1):374. 2022-11-19 [PMID: 36402949] (Human)
• A Silva-Reis, MA Rodrigues, R Moraes-Fer, TG Gonçalves-, VH Souza-Palm, HC Aquino-San, ALL Bachi, LVF de Oliveir, RÁB Lopes-Mart, I Oliveira-S, R Albertini, CR Frison, RP Vieira Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women Frontiers in Physiology, 2022-09-07;13(0):946402. 2022-09-07 [PMID: 36160852] (Human)
• M Yeganeh-Ha, H Najafipour, F Rostamzade, A Naghibzade Klotho and SIRT1 changes from pre-diabetes to diabetes and pre-hypertension to hypertension Diabetology & metabolic syndrome, 2021-10-20;13(1):115. 2021-10-20 [PMID: 34670596] (Human)
• MAR Brandao-Ra, R Moraes-Fer, MC Oliveira-J, A Santos-Dia, ALL Bachi, G Gabriela-P, S de Oliveir, AC Araújo-Ros, LVF Oliveira, CR Frison, WL do Prado, RP Raju, PB Balagopal, RP Vieira Pulmonary function changes in older adults with and without metabolic syndrome Scientific Reports, 2021-08-30;11(1):17337. 2021-08-30 [PMID: 34462482] (Human)
• WY Liang, LH Wang, JH Wei, QL Li, QY Li, Q Liang, NQ Hu, LH Li No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population Scientific Reports, 2021-01-27;11(1):2374. 2021-01-27 [PMID: 33504927] (Human)
• A Farías-Bas, HR Martínez-R, EF Gómez-Garc, AM Cueto-Manz, L Cortés-San, LE Hernández-, G Ramírez-Ló, F Mendoza-Ca Circulating Levels of Soluble Klotho and Fibroblast Growth Factor 23 in Mexican Diabetic Patients and Its Association With Early Nephropathy Arch. Med. Res., 2019-02-01;0(0):. 2019-02-01 [PMID: 30718148] (Human)
• A Chen, Y Sun, J Cui, B Zhao, H Wang, X Chen, Y Mao Associations of sclerostin with carotid artery atherosclerosis and all-cause mortality in Chinese patients undergoing maintenance hemodialysis BMC Nephrol, 2018-10-12;19(1):264. 2018-10-12 [PMID: 30314461] (Human)
• Almroth G, Lonn J, Uhlin F, Brudin L, Andersson B, Hahn-Zoric M Sclerostin, TNF-alpha and Interleukin-18 Correlate and are Together with Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients. Scand J Immunol, 2016-01-01;83(1):58-63. 2016-01-01 [PMID: 26448366] (Human)

FAQs for Klotho (DY5334-05). (Showing 1 - 2 of 2 FAQs).

1. I study physiology (PhD) and I need a klotho kit.
   • A list of our klotho products can be found here. I am not entirely sure what you are looking for as I don't have your complete message for some reason. Can you please clarify what you are looking for?
2. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: KL