Human Klotho DuoSet ELISA, 5 Plate



Product Details

Reactivity HuSpecies Glossary
Applications ELISA

Order Details

Human Klotho DuoSet ELISA, 5 Plate Summary

Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
No significant interference observed with available related molecules.
Read Publications using DY5334-05.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Klotho DuoSet ELISA, 5 Plate

  • EC 3.2.1
  • EC
  • KL
  • Klotho


The Klotho proteins, Klotho and Klotho beta (beta KL), are type I transmembrane glycoproteins with extracellular regions that contain two beta-glycosidase-like repeats. Klotho has both membrane-bound and soluble forms; the soluble form predominates and consists of only the first beta-glycosidase-like repeat. Klotho has beta-glucuronidase activity against select steroid beta-glucuronides, appears to regulate calcium and vitamin D levels in serum, and is associated with premature aging.

Klotho beta, a divergent structural member of the glycosidase I superfamily, is primarily expressed in the liver and pancreas, with lower expression in adipose tissue. Klotho beta mediates the interaction of FGF-15 (human FGF-19) with FGF Receptor 4 in the liver, which negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes. Klotho beta is also a cofactor for the interaction of FGF-21 with FGF Receptor 1c in adipocytes. The expression pattern of Klotho beta suggests it may play a role in lipid metabolism.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: BA
Species: Mu
Applications: BA
Species: Hu
Applications: BA
Species: Hu
Applications: IHC, WB
Species: Hu
Applications: ELISA
Species: Hu
Applications: BA
Species: Hu
Applications: BA
Species: Hu(-), Mu
Applications: ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
Species: Hu, Mu
Applications: CyTOF-ready, Flow, IHC, Simple Western, WB
Species: Bv, Hu, Mu
Applications: CyTOF-ready, ICC, IHC, ICFlow
Species: Hu
Applications: ELISA, AP, PA, WB
Species: Mu
Applications: ELISA
Species: Hu
Applications: BA
Species: Hu
Applications: BA
Species: Hu
Applications: CyTOF-ready, Flow, ICC, IHC, IHC-P, WB
Species: Hu
Applications: BA
Species: Hu
Applications: IHC, IHC-P, PEP-ELISA, WB
Species: Hu
Applications: ELISA, AP, PA, WB

Publications for Klotho (DY5334-05)(6)

We have publications tested in 1 confirmed species: Human.

Filter By Application
All Applications
Filter By Species
All Species
Showing Publications 1 - 6 of 6.
Publications using DY5334-05 Applications Species
M Yeganeh-Ha, H Najafipour, F Rostamzade, A Naghibzade Klotho and SIRT1 changes from pre-diabetes to diabetes and pre-hypertension to hypertension Diabetology & metabolic syndrome, 2021;13(1):115. 2021 [PMID: 34670596] (Human) Human
MAR Brandao-Ra, R Moraes-Fer, MC Oliveira-J, A Santos-Dia, ALL Bachi, G Gabriela-P, S de Oliveir, AC Araújo-Ros, LVF Oliveira, CR Frison, WL do Prado, RP Raju, PB Balagopal, RP Vieira Pulmonary function changes in older adults with and without metabolic syndrome Scientific Reports, 2021;11(1):17337. 2021 [PMID: 34462482] (Human) Human
WY Liang, LH Wang, JH Wei, QL Li, QY Li, Q Liang, NQ Hu, LH Li No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population Scientific Reports, 2021;11(1):2374. 2021 [PMID: 33504927] (Human) Human
A Farías-Bas, HR Martínez-R, EF Gómez-Garc, AM Cueto-Manz, L Cortés-San, LE Hernández-, G Ramírez-Ló, F Mendoza-Ca Circulating Levels of Soluble Klotho and Fibroblast Growth Factor 23 in Mexican Diabetic Patients and Its Association With Early Nephropathy Arch. Med. Res., 2019;0(0):. 2019 [PMID: 30718148] (Human) Human
A Chen, Y Sun, J Cui, B Zhao, H Wang, X Chen, Y Mao Associations of sclerostin with carotid artery atherosclerosis and all-cause mortality in Chinese patients undergoing maintenance hemodialysis BMC Nephrol, 2018;19(1):264. 2018 [PMID: 30314461] (Human) Human
Almroth G, Lonn J, Uhlin F, Brudin L, Andersson B, Hahn-Zoric M Sclerostin, TNF-alpha and Interleukin-18 Correlate and are Together with Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients. Scand J Immunol, 2015;83(1):58-63. 2015 [PMID: 26448366] (Human) Human

Reviews for Klotho (DY5334-05) (0)

There are no reviews for Klotho (DY5334-05). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Klotho (DY5334-05). (Showing 1 - 1 of 1 FAQs).

  1. I study physiology (PhD) and I need a klotho kit.
    • A list of our klotho products can be found here. I am not entirely sure what you are looking for as I don't have your complete message for some reason. Can you please clarify what you are looking for?

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Review this Product

Be the first to review our Human Klotho DuoSet ELISA, 5 Plate and receive a gift card or discount.


Gene Symbol KL