Human IL-33 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-33 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-33 DuoSet ELISA, 15 Plate

• C9orf26
• C9orf26chromosome 9 open reading frame 26 (NF-HEV)
• DKFZp586H0523
• DVS27
• DVS27-related protein
• IL1F11
• IL-1F11
• IL33
• IL-33
• interleukin 33
• Interleukin-1 family member 11
• interleukin-33
• NFHEV
• NF-HEV
• NF-HEVNFEHEV
• Nuclear factor from high endothelial venules
• RP11-575C20.2

Background

IL-33 (Interleukin-33) is released from physically damaged or necrotic cells. It triggers Th2-biased immune cell activation at sites of inflammation as well as regulatory T cell and M2 macrophage expansion. It additionally induces angiogenesis, promotes tumor cell migration and invasion, limits cardiac myocyte hypertrophy, and limits the development of atherosclerotic plaques. IL-33 signals through a receptor complex composed of ST2 and IL-1 RAcP. IL-1 RAcP also associates with IL-1 RI, IL-1 RII, IL-1 R6, and SCF R/c-kit. Soluble isoforms of ST2 and IL-1 RAcP function as decoy receptors that regulate IL-33 bioactivity.

Publications for IL-33 (DY3625B)(36)

Publications using DY3625B

• Jiao, M;Wang, C;Tang, X;Dai, C;Zhang, N;Fan, A;Qian, Z;Liu, S;Zhang, F;Li, B;Xu, Y;Tan, Z;Gong, F;Lu, Y;Zheng, F; Active secretion of IL-33 from astrocytes is dependent on TMED10 and promotes central nervous system homeostasis Brain, behavior, and immunity 2024-04-24 [PMID: 38663774] (Mouse, Transgenic Mouse)
• Raphael, HE;Hassan, GF;Osorio, OA;Cohen, LS;Payne, MD;Katz-Kiriakos, E;Tata, I;Hicks, J;Byers, DE;Zhang, B;Alexander-Brett, J; Activator protein transcription factors coordinate human IL-33 expression from noncanonical promoters in chronic airway disease JCI insight 2024-03-08 [PMID: 38456508] (Human)
• Coufal, S;Kverka, M;Kreisinger, J;Thon, T;Rob, F;Kolar, M;Reiss, Z;Schierova, D;Kostovcikova, K;Roubalova, R;Bajer, L;Jackova, Z;Mihula, M;Drastich, P;Tresnak Hercogova, J;Novakova, M;Vasatko, M;Lukas, M;Tlaskalova-Hogenova, H;Jiraskova Zakostelska, Z; Serum TGF-?1 and CD14 Predicts Response to Anti-TNF-? Therapy in IBD Journal of immunology research 2023-06-20 [PMID: 37383609] (Human)
• England, E;Rees, DG;Scott, IC;Carmen, S;Chan, DTY;Chaillan Huntington, CE;Houslay, KF;Erngren, T;Penney, M;Majithiya, JB;Rapley, L;Sims, DA;Hollins, C;Hinchy, EC;Strain, MD;Kemp, BP;Corkill, DJ;May, RD;Vousden, KA;Butler, RJ;Mustelin, T;Vaughan, TJ;Lowe, DC;Colley, C;Cohen, ES; Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction Scientific reports 2023-06-17 [PMID: 37330528] (Human)
• Jeon, YJ;Gil, CH;Won, J;Jo, A;Kim, HJ; Symbiotic microbiome Staphylococcus epidermidis restricts IL-33 production in allergic nasal epithelium via limiting the cellular necroptosis BMC microbiology 2023-05-26 [PMID: 37237381] (Mouse)
• J Nesic, B Ljujic, V Rosic, A Djukic, M Rosic, I Petrovic, N Zornic, IP Jovanovic, S Petrovic, S Djukic Adiponectin and Interleukin-33: Possible Early Markers of Metabolic Syndrome Journal of Clinical Medicine, 2022-12-24;12(1):. 2022-12-24 [PMID: 36614933] (Human)
• MH Urban, S Stojkovic, S Demyanets, C Hengstenbe, A Valipour, J Wojta, OC Burghuber Soluble ST2 and All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease-A 10-Year Cohort Study Journal of Clinical Medicine, 2021-12-23;11(1):. 2021-12-23 [PMID: 35011794] (Human)
• W Fonseca, N Asai, K Yagi, CA Malinczak, G Savickas, CC Johnson, S Murray, EM Zoratti, NW Lukacs, J Li, CF Schuler Iv COVID-19 Modulates Inflammatory and Renal Markers That May Predict Hospital Outcomes among African American Males Viruses, 2021-12-02;13(12):. 2021-12-02 [PMID: 34960684] (Human)
• ICS Dias, SM de Campos-, ELM Vieira, APL Mota, PS Azevedo, VTDS Anício, FC Guimarães, LM Mantovani, BF Cruz, AL Teixeira, JV Salgado Adiponectin and Stnfr2 peripheral levels are associated with cardiovascular risk in patients with schizophrenia Journal of psychiatric research, 2021-11-09;0(0):. 2021-11-09 [PMID: 34785039] (Human)
• R Rezar, V Paar, C Seelmaier, I Pretsch, P Schwaiger, K Kopp, R Kaufmann, TK Felder, E Prinz, G Gemes, R Pistulli, UC Hoppe, B Wernly, M Lichtenaue Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study Scientific Reports, 2021-11-05;11(1):21756. 2021-11-05 [PMID: 34741120] (Human)
• T Saito, T Ichikawa, T Numakura, M Yamada, A Koarai, N Fujino, K Murakami, S Yamanaka, Y Sasaki, Y Kyogoku, K Itakura, H Sano, K Takita, R Tanaka, T Tamada, M Ichinose, H Sugiura PGC-1&alpha regulates airway epithelial barrier dysfunction induced by house dust mite Respiratory Research, 2021-02-19;22(1):63. 2021-02-19 [PMID: 33607992] (Human)
• AER Oliveira, MCA Pereira, AT Belew, LRP Ferreira, LMN Pereira, EGA Neves, MDCP Nunes, BA Burleigh, WO Dutra, NM El-Sayed, RT Gazzinelli, SMR Teixeira Gene expression network analyses during infection with virulent and avirulent Trypanosoma cruzi�strains unveil a role for fibroblasts in neutrophil recruitment and activation PLoS Pathog., 2020-08-18;16(8):e1008781. 2020-08-18 [PMID: 32810179] (Human)
• T Li, Z Zhang, JG Bartolacci, GK Dwyer, Q Liu, L Mathews, M Velayutham, A Roessing, YC Lee, H Dai, S Shiva, MH Oberbarnsc, JL Dziki, SJ Mullett, SG Wendell, JD Wilkinson, SA Webber, MA Wood-Trage, SC Watkins, AJ Demetris, GS Hussey, SF Badylak, HR Turnquist Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection J. Clin. Invest., 2020-10-01;0(0):. 2020-10-01 [PMID: 32644975] (Human)
• S Demyanets, C Kaun, A Kaider, W Speidl, M Prager, S Oravec, P Hohensinne, J Wojta, G Rega-Kaun The pro-inflammatory marker soluble suppression of tumorigenicity-2 (ST2) is reduced especially in diabetic morbidly obese patients undergoing bariatric surgery Cardiovasc Diabetol, 2020-02-26;19(1):26. 2020-02-26 [PMID: 32101157] (Human)
• D Izadi, TB Layton, L Williams, F McCann, M Cabrita, AI Espirito S, W Xie, M Fritzsche, H Colin-York, M Feldmann, KS Midwood, J Nanchahal Identification of TNFR2 and IL-33 as therapeutic targets in localized fibrosis Sci Adv, 2019-12-04;5(12):eaay0370. 2019-12-04 [PMID: 31840071] (Human)
• CJ Kuo, CY Chen, HR Lo, CL Feng, HY Wu, MZ Huang, TN Liao, YA Chen, CH Lai Helicobacter pylori Induces IL-33 Production and Recruits ST-2 to Lipid Rafts to Exacerbate Inflammation Cells, 2019-10-21;8(10):. 2019-10-21 [PMID: 31640262] (Human)
• N Schaunaman, A Sanchez, KG Dimasuay, N Pavelka, M Numata, R Alam, RJ Martin, HW Chu Interleukin 1 Receptor-Like 1 (IL1RL1) Promotes Airway Bacterial and Viral Infection and Inflammation Infect. Immun., 2019-06-20;87(7):. 2019-06-20 [PMID: 31061143] (Human)
• A Taracanova, I Tsilioni, P Conti, ER Norwitz, SE Leeman, TC Theoharide Substance P and IL-33 administered together stimulate a marked secretion of IL-1? from human mast cells, inhibited by methoxyluteolin Proc. Natl. Acad. Sci. U.S.A., 2018-09-19;0(0):. 2018-09-19 [PMID: 30232261] (Human)
• RF Hamilton, Z Wu, S Mitra, A Holian The Effects of Varying Degree of MWCNT Carboxylation on Bioactivity in Various In Vivo and In Vitro Exposure Models Int J Mol Sci, 2018-01-25;19(2):. 2018-01-25 [PMID: 29370073] (Human)
• C Li, K Chen, H Kang, Y Yan, K Liu, C Guo, J Qi, K Yang, F Wang, L Guo, C He, L Deng Double-stranded RNA released from damaged articular chondrocytes promotes cartilage degeneration via Toll-like receptor 3-interleukin-33 pathway Cell Death Dis, 2017-11-02;8(11):e3165. 2017-11-02 [PMID: 29095435] (Human)
• KA Krychtiuk, S Stojkovic, M Lenz, M Brekalo, K Huber, J Wojta, G Heinz, S Demyanets, WS Speidl Predictive value of low interleukin-33 in critically ill patients Cytokine, 2017-09-30;0(0):. 2017-09-30 [PMID: 28974430] (Human)
• GA Queiroz, RS Costa, NM Alcantara-, G Nunes de O, ML Barreto, VL Carneiro, CA Figueiredo IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population Int. J. Immunogenet, 2017-04-01;44(2):51-61. 2017-04-01 [PMID: 28266165] (Human)
• I Hentschke, A Graser, VO Melichar, A Kiefer, T Zimmermann, B Kro beta , P Haag, P Xepapadaki, NG Papadopoul, C Bogdan, S Finotto IL-33/ST2 immune responses to respiratory bacteria in pediatric asthma Sci Rep, 2017-03-06;7(0):43426. 2017-03-06 [PMID: 28262704] (Human)
• Gisa Tiegs A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis J. Immunol., 2016-11-21;0(0):. 2016-11-21 [PMID: 27872212] (Human)
• Calven J, Akbarshahi H, Menzel M, Ayata C, Idzko M, Bjermer L, Uller L Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33. J Transl Med, 2015-08-29;13(0):281. 2015-08-29 [PMID: 26318341] (Human)
• Sundnes O, Pietka W, Loos T, Sponheim J, Rankin A, Pflanz S, Bertelsen V, Sitek J, Hol J, Haraldsen G, Khnykin D Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences. J Invest Dermatol, 2015-03-04;135(7):1771-80. 2015-03-04 [PMID: 25739051] (Human)
• Hasan , Amal, Al-Ghimlas , Fahad, Warsame , Samia, Al-Hubail , Asma, Ahmad , Rasheed, Bennakhi , Abdullah, Al-Arouj , Monira, Behbehani , Kazem, Dehbi , Mohammed, Dermime , Said IL-33 is negatively associated with the BMI and confers a protective lipid/metabolic profile in non-diabetic but not diabetic subjects. BMC Immunol, 2014-05-10;15(0):19. 2014-05-10 [PMID: 24886535] (Human)
• Lu , Da-Peng, Zhou , Xiang-Yu, Yao , Lu-Tian, Liu , Cai-Gang, Ma , Wei, Jin , Feng, Wu , Yun-Fei Serum soluble ST2 is associated with ER-positive breast cancer. BMC Cancer, 2014-03-18;14(0):198. 2014-03-18 [PMID: 24636276] (Human)
• Guerrero C, Arrieta A, Ramirez N, Rodriguez L, Vega R, Bosch I, Rodriguez J, Narvaez C, Salgado D High plasma levels of soluble ST2 but not its ligand IL-33 is associated with severe forms of pediatric dengue. Cytokine, 2013-01-26;61(3):766-71. 2013-01-26 [PMID: 23357301] (Human)
• Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J. Exp. Med., 2012-07-16;209(8):1505-17. 2012-07-16 [PMID: 22802353] (Human)
• Kamekura R, Kojima T, Takano K, Go M, Sawada N, Himi T The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis. Clin. Exp. Allergy, 2012-02-01;42(2):218-28. 2012-02-01 [PMID: 22233535] (Human)
• Granne I, Southcombe JH, Snider JV ST2 and IL-33 in pregnancy and pre-eclampsia. PLoS ONE, 2011-09-16;6(9):e24463. 2011-09-16 [PMID: 21949719] (Human)
• Rechardt M, Shiri R, Matikainen S, Viikari-Juntura E, Karppinen J, Alenius H Soluble IL-1RII and IL-18 are associated with incipient upper extremity soft tissue disorders. Cytokine, 2011-03-02;54(2):149-53. 2011-03-02 [PMID: 21371906] (Human)
• Miyagaki T, Sugaya M High Levels of Soluble ST2 and Low Levels of IL-33 in Sera of Patients with HIV Infection. J. Invest. Dermatol., 2010-12-09;131(0):794. 2010-12-09 [PMID: 21150924] (Human)
• Mildner M, Storka A, Lichtenauer M Primary sources and immunological prerequisites for sST2 secretion in humans. Cardiovasc. Res., 2010-04-02;87(4):769-77. 2010-04-02 [PMID: 20363761] (Human)
• Nishida A, Andoh A, Imaeda H, Inatomi O, Shiomi H, Fujiyama Y Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts. Gut, 2009-12-08;59(4):531-41. 2009-12-08 [PMID: 19996325] (Human)

Review for IL-33 (DY3625B) (1)

Average Rating: 4

(Based on 1 review)

reviewed by: Patricia Carulla Martí 06/28/2023

Summary

• Sample Tested: Cultured Human Keratinocytes,Supernatant from cultured human epidermal keratinocytes (HEKa)
• Lot: P163207