Human IL-31 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-31 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL31

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-31 DuoSet ELISA, 15 Plate

• IL31
• IL-31
• IL-31interleukin-31
• interleukin 31

Background

Interleukin 31 (IL-31) is a secreted, T-cell-derived, 24-kDa, short-chain member of the alpha-helical family of cytokines. The mature region is 141 amino acids (aa) in length and exhibits four alpha-helices. Human and mouse IL-31 are highly divergent at 24% aa sequence identity. The receptor for IL-31 is found on keratinocytes and monocytes. It is a heterodimer composed of the Oncostatin M receptor and a novel gp130-related molecule. IL-31 may be involved in pruritis, or skin itching.

Publications for IL-31 (DY2824)(9)

Publications using DY2824

• Younossi, ZM;Estep, MJ;Felix, S;Lam, B;Mukherjee, S;Swift, B;Casillas, L;de Souza, AR;Hunnicutt, J;McLaughlin, MM;Racila, A;Nader, F;Stepanova, M; Serum Bile Acid Elevation is an Independently Associated With Pruritus in Patients With At-risk Metabolic Dysfunction-associated Steatotic Liver Disease Journal of clinical and experimental hepatology 2025-03-20 [PMID: 40256443] (Human)
• D Tortolani, C Di Meo, S Standoli, F Ciaramella, S Kadhim, E Hsu, C Rapino, M Maccarrone Rare Phytocannabinoids Exert Anti-Inflammatory Effects on Human Keratinocytes via the Endocannabinoid System and MAPK Signaling Pathway International Journal of Molecular Sciences, 2023-02-01;24(3):. 2023-02-01 [PMID: 36769042] (Human)
• R Kishi, S Toyama, M Tominaga, Y Kamata, E Komiya, T Kaneko, Y Suga, K Takamori Effects of Dupilumab on Itch-Related Events in Atopic Dermatitis: Implications for Assessing Treatment Efficacy in Clinical Practice Cells, 2023-01-05;12(2):. 2023-01-05 [PMID: 36672173] (Human)
• D Parashar, A Geethadevi, MR Aure, J Mishra, J George, C Chen, MK Mishra, A Tahiri, W Zhao, B Nair, Y Lu, LS Mangala, C Rodriguez-, G Lopez-Bere, AKS Camara, M Liang, JS Rader, R Ramchandra, M You, AK Sood, VN Kristensen, GB Mills, S Pradeep, P Chaluvally miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer Cell Rep, 2019-12-24;29(13):4389-4406.e10. 2019-12-24 [PMID: 31875548] (Human)
• MC Kang, K Cho, JH Lee, L Subedi, S Yumnam, SY Kim Effect of Resveratrol-Enriched Rice on Skin Inflammation and Pruritus in the NC/Nga Mouse Model of Atopic Dermatitis Int J Mol Sci, 2019-03-21;20(6):. 2019-03-21 [PMID: 30901835] (Mouse)
• K Yamamura, T Uruno, A Shiraishi, Y Tanaka, M Ushijima, T Nakahara, M Watanabe, M Kido-Nakah, I Tsuge, M Furue, Y Fukui The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction Nat Commun, 2017-01-09;8(0):13946. 2017-01-09 [PMID: 28067314] (Human)
• Tseng W, Lo M, Guo M, Hsieh K, Chang W, Kuo H IL-31 associated with coronary artery lesion formation in Kawasaki disease. PLoS ONE, 2014-08-14;9(8):e105195. 2014-08-14 [PMID: 25122210] (Human)
• Kim S, Kim HJ, Yang HS IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis. Ann Dermatol, 2011-11-03;23(4):468-73. 2011-11-03 [PMID: 22148014] (Human)
• Raap U, Wichmann K, Bruder M, Stander S, Wedi B, Kapp A, Werfel T Correlation of IL-31 serum levels with severity of atopic dermatitis. J. Allergy Clin. Immunol., 2008-08-01;122(2):421-3. 2008-08-01 [PMID: 18678344] (Human)

FAQs for IL-31 (DY2824). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: IL31