Human IL-22 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-22 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL22

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-22 DuoSet ELISA, 15 Plate

• Cytokine Zcyto18
• IL-10-related T-cell-derived inducible factor
• IL22
• IL-22
• IL-D110
• IL-TIF
• ILTIFIL-10-related T-cell-derived-inducible factor
• IL-TIFMGC79382
• interleukin 22
• interleukin-22
• MGC79384
• TIFa
• TIFIL-23
• zcyto18

Background

IL-22 (Interleukin-22) is a cytokine that induces the production of reactive oxygen species, IL-6, IL-10, and TNF-alpha as well as neutrophil infiltration during inflammation. It also supports the integrity of epithelial barriers and induces epithelial cell proliferation during wound healing. IL-22 signals through a receptor complex consisting of IL-22 R and IL-10 R beta. IL-10 R beta is a shared component of the receptor complexes for IL-10, IL-26, IL-28, and IL-29. IL-22 additionally binds to IL-22BP which blocks the interaction of IL-22 with IL-22 R.

Publications for IL-22 (DY782)(35)

Publications using DY782

• Courtemanche, O;Huppé, CA;Blais-Lecours, P;Maranda, C;Morissette, MC;Blanchet, MR;Dion, G;Marsolais, D; Ex Vivo Overactivation of Lymphocyte Subsets in Fibrotic Hypersensitivity Pneumonitis Is Blunted by a Sphingosine-1-Phosphate Receptor Ligand International journal of molecular sciences 2025-03-29 [PMID: 40243992] (Human)
• Navas, A;Matzaraki, V;van Eekeren, LE;Blaauw, MJT;Groenendijk, AL;Vos, WAJW;Jacobs-Cleophas, M;Dos Santos, JC;van der Ven, AJAM;Joosten, LAB;Netea, MG; Plasma Proteomic Signature as a Predictor of Age Advancement in People Living With HIV Aging cell 2025-01-15 [PMID: 39812213] (Human)
• Pourfarzam, S;Ardestani, SK;Jamali, T;Ghazanfari, H;Naghizadeh, MM;Faghihzadeh, S;Yaraee, R;Ghazanfari, Z;Ghazanfari, T; Distinct inflammatory profiles in mustard lung: A study of sulfur mustard-exposed patients with serious pulmonary complications International immunopharmacology 2024-12-16 [PMID: 39689604] (Human)
• Duijzer, R;Dalloyaux, D;Boerrigter, MM;Lemmers, H;Dijkstra, H;van Emst, L;Te Morsche, RHM;Jaeger, M;Joosten, LAB;Drenth, JPH; Exploring the innate immune response in polycystic liver disease Cytokine 2024-12-01 [PMID: 39541862] (Human)
• Correia, AF;Oliveira, CGC;Oliveira, DC;Pereira, MC;Carvalho, FA;Martins, ECC;Oliveira, DC; Circulating Interleukin-22 in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Journal of clinical medicine 2024-08-23 [PMID: 39274184] (Human)
• Law, C;Wacleche, VS;Cao, Y;Pillai, A;Sowerby, J;Hancock, B;Horisberger, A;Bracero, S;Skidanova, V;Li, Z;Adejoorin, I;Dillon, E;Benque, IJ;Nunez, DP;Simmons, DP;Keegan, J;Chen, L;Baker, T;Brohawn, PZ;Al-Mossawi, H;Hao, LY;Jones, B;Rao, N;Qu, Y;Alves, SE;Accelerating Medicines Partnership: RA/SLE Network, ;Jonsson, AH;Shaw, KS;Vleugels, RA;Massarotti, E;Costenbader, KH;Brenner, MB;Lederer, JA;Hultquist, JF;Choi, J;Rao, DA; Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus Nature 2024-07-10 [PMID: 38987586] (Human)
• Wu, WC;Shiu, C;Tong, TK;Leung, SO;Hui, CW; Suppression of NK Cell Activation by JAK3 Inhibition: Implication in the Treatment of Autoimmune Diseases Journal of immunology research 2023-12-08 [PMID: 38106519] (Human)
• Fiorillo, A;Gallego, JJ;Casanova-Ferrer, F;Giménez-Garzó, C;Urios, A;Ballester, MP;Durbán, L;Rios, MP;Megías, J;San Miguel, T;Kosenko, E;Escudero-García, D;Benlloch, S;Felipo, V;Montoliu, C; Mild Cognitive Impairment Is Associated with Enhanced Activation of Th17 Lymphocytes in Non-Alcoholic Fatty Liver Disease International journal of molecular sciences 2023-06-20 [PMID: 37373554] (Human)
• Fiorillo, A;Gallego, JJ;Casanova-Ferrer, F;Giménez-Garzó, C;Urios, A;Ballester, MP;Durbán, L;Rios, MP;Megías, J;San Miguel, T;Kosenko, E;Escudero-García, D;Benlloch, S;Felipo, V;Montoliu, C; Mild Cognitive Impairment Is Associated with Enhanced Activation of Th17 Lymphocytes in Non-Alcoholic Fatty Liver Disease International journal of molecular sciences 2023-06-20 [PMID: 37373554] ( Human)
• LU Teufel, CI van der Ma, V Klück, A Simons, A Hoischen, V Vernimmen, LAB Joosten, RJW Arts Effect of exogenous IL-37 on immune cells from a patient carrying a potential IL37 loss-of-function variant: A case study Cytokine, 2022-12-05;162(0):156102. 2022-12-05 [PMID: 36476991] (Human)
• Kartasheva-Ebertz D, Gaston J, Lair-Mehiri L, Mottez E, Buivan T, Massault P, Scatton O, Gaujoux S, Vaillant J, Pol S, Lagaye S IL-17A in Human Liver: Significant Source of Inflammation and Trigger of Liver Fibrosis Initiation. Int J Mol Sci, 2022-08-29;23(17):. 2022-08-29 [PMID: 36077175] (Human)
• G Szylar, R Wysoczansk, H Marshall, DJB Marks, R José, ME Ehrenstein, JS Brown A novel Streptococcus pneumoniae human challenge model demonstrates Treg lymphocyte recruitment to the infection site Scientific Reports, 2022-03-07;12(1):3990. 2022-03-07 [PMID: 35256717] (Human)
• A Tosi, L Nardinocch, ML Carbone, L Capriotti, E Pagani, S Mastroeni, C Fortes, F Scopelliti, C Cattani, F Passarelli, A Rosato, S D'Atri, CM Failla, A Cavani Reduced Interleukin-17-Expressing Cells in Cutaneous Melanoma Biomedicines, 2021-12-16;9(12):. 2021-12-16 [PMID: 34944746] (Human)
• B Texler, A Zollner, V Reinstadle, SJ Reider, S Macheiner, B Jelusic, A Pfister, C Watschinge, N Przysiecki, H Tilg, H Oberacher, AR Moschen Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics Cellular and Molecular Gastroenterology and Hepatology, 2021-10-06;0(0):. 2021-10-06 [PMID: 34624526] (Human)
• SL Mathiasen, L Gall-Mas, IS Pateras, SDP Theodorou, MRJ Namini, MB Hansen, OCB Martin, CK Vadivel, K Ntostoglou, D Butter, M Givskov, C Geisler, AN Akbar, VG Gorgoulis, T Frisan, N Ødum, T Krejsgaard Bacterial genotoxins induce T�cell senescence Cell Reports, 2021-06-08;35(10):109220. 2021-06-08 [PMID: 34107253] (Human)
• M De Angelis, I Ferrocino, FM Calabrese, F De Filippi, N Cavallo, S Siragusa, S Rampelli, R Di Cagno, K Rantsiou, L Vannini, N Pellegrini, C Lazzi, S Turroni, N Lorusso, M Ventura, M Chieppa, E Neviani, P Brigidi, PW O'Toole, D Ercolini, M Gobbetti, L Cocolin Diet influences the functions of the human intestinal microbiome Sci Rep, 2020-03-06;10(1):4247. 2020-03-06 [PMID: 32144387] (Human)
• ML Tiirikaine, A Woetmann, H Norsgaard, LF Santamaria, P Lovato Ex vivo culture of lesional psoriasis skin for pharmacological testing J. Dermatol. Sci., 2019-12-27;0(0):. 2019-12-27 [PMID: 31948839] (Human)
• NE Powers, B Swartzwelt, C Marchetti, DM de Graaf, A Lerchner, M Schlapschy, R Datar, U Binder, CK Edwards, A Skerra, CA Dinarello PASylation of IL-1 Receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis J. Biol. Chem., 2019-12-09;0(0):. 2019-12-09 [PMID: 31819009] (Human)
• G Müller, C Lübow, G Weindl Lysosomotropic beta blockers induce oxidative stress and IL23A production in Langerhans cells Autophagy, 2019-11-07;0(0):1-16. 2019-11-07 [PMID: 31668121] (Human)
• R Gramlich, E Aliahmadi, M Peiser In Vitro Induction of T Helper 17 Cells by Synergistic Activation of Human Monocyte-Derived Langerhans Cell-Like Cells with Bacterial Agonists Int J Mol Sci, 2019-03-19;20(6):. 2019-03-19 [PMID: 30893757] (Human)
• A Guillon, D Brea, E Luczka, V Hervé, S Hasanat, C Thorey, M Pérez-Cruz, J Hordeaux, J Mankikian, P Gosset, C Coraux, M Si-Tahar Inactivation of the interleukin-22 pathway in the airways of cystic fibrosis patients Cytokine, 2018-10-28;0(0):. 2018-10-28 [PMID: 30377053] (Human)
• YE Bar-Ephrai, F Cornelisse, N Papazian, T Konijn, RM Hoogenboez, MA Sanders, BA Westerman, M Gönültas, J Kwekkeboom, JMM Den Haan, RM Reijmers, RE Mebius, T Cupedo Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation Cell Rep, 2017-10-17;21(3):823-833. 2017-10-17 [PMID: 29045847] (Human)
• GR Kathamuthu, K Moideen, D Baskaran, VV Banurekha, D Nair, G Sekar, R Sridhar, B Vidyajayan, G Gajendrara, DK Parandhama, A Srinivasan, S Babu TB lymphadenitis is associated with enhanced baseline and antigen - specific induction of Type 1 and Type 17 cytokines and reduced IL-1? and IL-18 at the site of infection Clin. Vaccine Immunol, 2017-05-05;0(0):. 2017-05-05 [PMID: 28249842] (Human)
• MJ Fábrega, L Aguilera, R Giménez, E Varela, M Alexandra, M Antolín, J Badía, L Baldomà Activation of Immune and Defense Responses in the Intestinal Mucosa by Outer Membrane Vesicles of Commensal and Probiotic Escherichia coli Strains Front Microbiol, 2016-05-11;7(0):705. 2016-05-11 [PMID: 27242727] (Human)
• Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis PLoS ONE, 2016-05-06;11(5):e0154817. 2016-05-06 [PMID: 27152519] (Human)
• Dorgham K, Amoura Z, Parizot C, Arnaud L, Frances C, Pionneau C, Devilliers H, Pinto S, Zoorob R, Miyara M, Larsen M, Yssel H, Gorochov G, Mathian A Ultraviolet light converts propranolol, a nonselective beta-blocker and potential lupus-inducing drug, into a proinflammatory AhR ligand. Eur J Immunol, 2015-10-16;45(11):3174-87. 2015-10-16 [PMID: 26354876] (Human)
• Chalermwatanachai T, Zhang N, Holtappels G, Bachert C Association of Mucosal Organisms with Patterns of Inflammation in Chronic Rhinosinusitis. PLoS ONE, 2015-08-14;10(8):e0136068. 2015-08-14 [PMID: 26275068] (Human)
• Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation. Eur J Immunol, 2014-02-18;44(5):1330-40. 2014-02-18 [PMID: 24549985] (Human)
• Cai , Tao, Wang , Qian, Zhou , Qingyun, Wang , Chaokui, Hou , Shengpin, Qi , Jian, Kijlstra , Aize, Yang , Peizeng Increased expression of IL-22 is associated with disease activity in Behcet's disease. PLoS ONE, 2013-03-19;8(3):e59009. 2013-03-19 [PMID: 23527071] (Human)
• Johnston A, Xing X, Swindell W, Kochkodan J, Riblett M, Nair R, Stuart P, Ding J, Voorhees J, Elder J, Gudjonsson J Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis. Hum Mol Genet, 2013-01-31;22(9):1807-15. 2013-01-31 [PMID: 23376980] (Human)
• van de Veerdonk FL, Stoeckman AK, Wu G, Boeckermann AN, Azam T, Netea MG, Joosten LA, Van der Meer JW, Hao R, Kalabokis V, Dinarello CA IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc. Natl. Acad. Sci. U.S.A., 2012-02-06;109(8):3001-5. 2012-02-06 [PMID: 22315422] (Human)
• Liu Y, Yang B, Ma J, Wang H, Huang F, Zhang J, Chen H, Wu C Interleukin-21 induces the differentiation of human Tc22 cells via phosphorylation of signal transducers and activators of transcription. Immunology, 2011-01-07;132(4):540-8. 2011-01-07 [PMID: 21214545] (Human)
• Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, Garcovich S, Traidl-Hoffmann C, Albanesi C, Cavani A IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes. J. Immunol., 2010-03-31;184(9):4880-8. 2010-03-31 [PMID: 20357258] (Human)
• Kisand K, Boe Wolff AS, Podkrajsek KT, Tserel L, Link M, Kisand KV, Ersvaer E, Perheentupa J, Erichsen MM, Bratanic N, Meloni A, Cetani F, Perniola R, Ergun-Longmire B, Maclaren N, Krohn KJ, Pura M, Schalke B, Strobel P, Leite MI, Battelino T, Husebye ES, Peterson P, Willcox N, Meager A Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J. Exp. Med., 2010-02-01;207(2):299-308. 2010-02-01 [PMID: 20123959] (Human)
• Schulz SM, Kohler G, Schutze N, Knauer J, Straubinger RK, Chackerian AA, Witte E, Wolk K, Sabat R, Iwakura Y, Holscher C, Muller U, Kastelein RA, Alber G Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17. J. Immunol., 2008-12-01;181(11):7891-901. 2008-12-01 [PMID: 19017979] (Mouse)

FAQs for IL-22 (DY782). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: IL22