Human HB-EGF Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human HB-EGF Quantikine ELISA Kit Summary

• Background: The Quantikine Human HB-EGF Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human HB-EGF in cell culture supernates, serum, plasma, saliva, urine, and human milk. It contains Sf 21-expressed recombinant human HB-EGF and antibodies raised against the recombinant factor. Results obtained using natural human HB-EGF showed linear curves that were parallel to the standard... curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring
  human HB-EGF.
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• Specificity: Natural and recombinant human HB-EGF.
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: HBEGF

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human HB-EGF Quantikine ELISA Kit

• diphtheria toxin receptor (heparin-binding epidermal growth factor-like growthfactor)
• Dtr
• DTRHEGFLdiphtheria toxin receptor (heparin-binding EGF-like growth factor)
• Dts
• DTSF
• HBEGF
• HB-EGF
• Hegfl
• heparin-binding EGF-like growth factor
• heparin-binding epidermal growth factor
• proheparin-binding EGF-like growth factor

Background

HB-EGF (Heparin-Binding EGF-like growth factor), also known as DTR, is produced by bronchial epithelium, visceral and vascular smooth muscle, CD4+ T cells, cardiac muscle, glomerular podocytes, keratinocytes, and IL-10-secreting regulatory macrophages. It activates both the EGF R/ErbB1 and ErbB4 receptors and has been linked to many cellular processes including proliferation, apoptosis, cell migration/invasion, differentiation, morphogenesis, and development. HB-EGF is also involved in several aspects of cancer development and progression.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for HB-EGF (DHBEG0)(5)

Publications using DHBEG0

• Yu, W;Biyik-Sit, R;Uzun, Y;Chen, CH;Thadi, A;Sussman, JH;Pang, M;Wu, CY;Grossmann, LD;Gao, P;Wu, DW;Yousey, A;Zhang, M;Turn, CS;Zhang, Z;Bandyopadhyay, S;Huang, J;Patel, T;Chen, C;Martinez, D;Surrey, LF;Hogarty, MD;Bernt, K;Zhang, NR;Maris, JM;Tan, K; Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring Nature genetics 2025-04-14 [PMID: 40229600] (Human)
• AJ Arribas, S Napoli, L Cascione, L Barnabei, G Sartori, E Cannas, E Gaudio, C Tarantelli, AA Mensah, F Spriano, A Zucchetto, FM Rossi, A Rinaldi, MC de Moura, S Jovic, RB Pittau, A Stathis, G Stussi, V Gattei, JR Brown, M Esteller, E Zucca, D Rossi, F Bertoni ERBB4-mediated signaling is a mediator of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms bioRxiv : the preprint server for biology, 2023-01-02;0(0):. 2023-01-02 [PMID: 36711490] (Human)
• D Balalis, D Tsakogiann, E Kalogera, S Kokkali, E Tripodaki, A Ardavanis, D Manatakis, D Dimas, N Koufopoulo, F Fostira, D Korkolis, I Misitzis, N Vassos, C Spiliopoul, D Vlachodimi, G Bletsa, N Arkadopoul Serum Concentration of Selected Angiogenesis-Related Molecules Differs among Molecular Subtypes, Body Mass Index and Menopausal Status in Breast Cancer Patients Oncogene, 2022-07-14;11(14):. 2022-07-14 [PMID: 35887839] (Human)
• JJ Zhang, CX Cao, LL Wan, W Zhang, ZJ Liu, JL Wang, Q Guo, H Tang Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway World Journal of Gastroenterology, 2022-05-07;28(17):1781-1797. 2022-05-07 [PMID: 35633908] (Human)
• N Hanata, Y Nagafuchi, Y Sugimori, S Kobayashi, Y Tsuchida, Y Iwasaki, H Shoda, K Fujio Serum Amphiregulin and Heparin-Binding Epidermal Growth Factor as Biomarkers in Patients with Idiopathic Inflammatory Myopathy Journal of Clinical Medicine, 2021-08-22;10(16):. 2021-08-22 [PMID: 34442026] (Human)

FAQs for HB-EGF (DHBEG0). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: HBEGF