Human GDF-15 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human GDF-15 Quantikine ELISA Kit Summary

• Background: The Quantikine Human GDF-15 immunoassay is a 3.5 hour solid phase ELISA designed to measure GDF-15 in cell culture supernates, serum, plasma, and urine. It contains CHO cell-expressed recombinant human GDF-15 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural GDF-15 showed linear curves that were parallel to the standard curves obtained using t...he Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values of naturally occurring GDF-15.
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• Specificity: Natural and recombinant human GDF-15
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: GDF15

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human GDF-15 Quantikine ELISA Kit

• GDF15
• GDF-15
• growth differentiation factor 15
• growth/differentiation factor 15
• Macrophage inhibitory cytokine 1
• MIC-1
• MIC-1NSAID-activated gene 1 protein
• MIC1Prostate differentiation factor
• NAG-1
• NAG-1NSAID-regulated gene 1 protein
• NSAID (nonsteroidal inflammatory drug)-activated protein 1
• PDF
• PDFGDF-15
• PLAB
• PLABNRG-1
• Placental bone morphogenetic protein
• Placental TGF-beta
• PTGF-beta
• PTGFBPTGF-beta

Background

Growth/differentiation factors (GDF-1 to GDF-15) are members of the BMP family of TGF-beta superfamily proteins. They are produced as inactive preproproteins which are then cleaved and assembled into active secreted homodimers. GDF dimers are disulfide-linked with the exception of GDF-3 and -9. GDF proteins are important during embryonic development, particularly in the skeletal, nervous, and muscular systems.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for GDF-15 (DGD150)(103)

Publications using DGD150

• Ferreira, R;Velho, TR;Pereira, RM;Pedroso, D;Draiblate, B;Constantino, S;Nobre, Â;Almeida, AG;Moita, LF;Pinto, F; Growth Differentiation Factor 15 as a Biomarker for Risk Stratification in the Cardiothoracic Surgery Intensive Care Unit Biomolecules 2024-12-13 [PMID: 39766300] (Human)
• Bathina, S;Lopez, VF;Prado, M;Ballato, E;Colleluori, G;Tetlay, M;Villareal, DT;Mediwala, S;Chen, R;Qualls, C;Armamento-Villareal, R; Health implications of racial differences in serum growth differentiation factor levels among men with obesity Physiological reports 2024-12-01 [PMID: 39668628] (Human)
• Ball, B;Xiao, W;Borthakur, G;Nguyen, LXT;Valerio, M;Venkatachalam, A;Marcucci, G;Stein, A;Thai, DL;Cook, D;Chan, K;Persaud, S;Levine, R;Abdel-Wahab, O;Ben-Neriah, Y;Stein, E; Phase I First-in-Human Dose Escalation Study of the oral Casein Kinase 1? and Cyclin Dependent Kinase 7/9 inhibitor BTX-A51 in advanced MDS and AML Research square 2024-10-15 [PMID: 39483885] (Human)
• Gollner, A;Rudolph, D;Weyer-Czernilofsky, U;Baumgartinger, R;Jung, P;Weinstabl, H;Ramharter, J;Grempler, R;Quant, J;Rinnenthal, J;Pérez Pitarch, A;Golubovic, B;Gerlach, D;Bader, G;Wetzel, K;Otto, S;Mandl, C;Boehmelt, G;McConnell, DB;Kraut, N;Sini, P; Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules Molecular cancer therapeutics 2024-09-11 [PMID: 39259562] (Human)
• Wang, Q;Farhadipour, M;Thijs, T;Sosoranga, ER;Van der Schueren, B;Ceulemans, LJ;Deleus, E;Lannoo, M;Tack, J;Depoortere, I; Bitter-tasting drugs tune GDF15 and GLP-1 expression via bitter taste or motilin receptors in the intestine of patients with obesity Molecular metabolism 2024-08-05 [PMID: 39111389] (Human)
• Deng, J;Pan, T;Wang, D;Hong, Y;Liu, Z;Zhou, X;An, Z;Li, L;Alfano, G;Li, G;Dolcetti, L;Evans, R;Vicencio, JM;Vlckova, P;Chen, Y;Monypenny, J;Gomes, CAC;Weitsman, G;Ng, K;McCarthy, C;Yang, X;Hu, Z;Porter, JC;Tape, CJ;Yin, M;Wei, F;Rodriguez-Justo, M;Zhang, J;Tejpar, S;Beatson, R;Ng, T; The MondoA-dependent TXNIP/GDF15 axis predicts oxaliplatin response in colorectal adenocarcinomas EMBO molecular medicine 2024-08-05 [PMID: 39103698] (Human)
• Liu, Q;Qin, L;Liang, Y;Xu, M;Zhang, J;Mo, X;Tang, X;Lu, Y;Wang, X;Cao, J;Huang, C;Rong, J;Teng, K;Zhao, L;Wu, S;Luo, L;Guan, Q;Zhang, T;Jin, W;Qin, J;Cai, J;Zhang, Z; Correlations between growth differentiation factor 15 (GDF-15) serum levels and gene polymorphism with type 2 diabetes mellitus Heliyon 2024-06-30 [PMID: 38988547] (Human)
• Nawrocka-Millward, S;Biegus, J;Fudim, M;Guzik, M;Iwanek, G;Ponikowski, P;Zymli?ski, R; The role of urine chloride in acute heart failure Scientific reports 2024-06-18 [PMID: 38890417] (Human)
• Christidis, G;Küppers, F;Karatayli, SC;Karatayli, E;Weber, SN;Lammert, F;Krawczyk, M; Skin advanced glycation end-products as indicators of the metabolic profile in diabetes mellitus: correlations with glycemic control, liver phenotypes and metabolic biomarkers BMC endocrine disorders 2024-03-05 [PMID: 38443880] (Human)
• Kim, HR;Kim, MJ;Jeon, JW;Ham, YR;Na, KR;Park, H;Kim, JJ;Choi, DE; Association between Serum GDF-15 and Cognitive Dysfunction in Hemodialysis Patients Biomedicines 2024-02-03 [PMID: 38397960] (Human)
• Ozdemir, E;Stavileci, B;Ozdemir, B;Aksoy, FA;Kahraman, S;Colakoglu Gevher, CZ;Ziyrek, M;Dogan, A; The association between growth differentiation factor 15 and presence and severity of coronary atherosclerosis Advances in medical sciences 2024-02-17 [PMID: 38368744] (Human)
• Shchelochkov, OA;Farmer, CA;Chlebowski, C;Adedipe, D;Ferry, S;Manoli, I;Pass, A;McCoy, S;Van Ryzin, C;Sloan, J;Thurm, A;Venditti, CP; Intellectual disability and autism in propionic acidemia: a biomarker-behavioral investigation implicating dysregulated mitochondrial biology Molecular psychiatry 2024-01-11 [PMID: 38200289] (Human)
• De Paepe, B;Bracke, KR;De Bleecker, JL; Retrospective Study Shows That Serum Levels of Chemokine CXCL10 and Cytokine GDF15 Support a Diagnosis of Sporadic Inclusion Body Myositis and Immune-Mediated Necrotizing Myopathy Brain sciences 2023-09-25 [PMID: 37891738] (Human)
• Nederveen, JP;Mastrolonardo, AJ;Xhuti, D;Di Carlo, A;Manta, K;Fuda, MR;Tarnopolsky, MA; Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves Body Composition in Overweight and Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Nutrients 2023-08-23 [PMID: 37686725] (Human)
• Shibasaki, I;Otani, N;Ouchi, M;Fukuda, T;Matsuoka, T;Hirota, S;Yokoyama, S;Kanazawa, Y;Kato, T;Shimizu, R;Tezuka, M;Takei, Y;Tsuchiya, G;Saito, S;Konishi, T;Ogata, K;Toyoda, S;Fukuda, H;Nakajima, T; Utility of growth differentiation factor-15 as a predictor of cardiovascular surgery outcomes: Current research and future directions Journal of cardiology 2023-08-28 [PMID: 37648079] (Human)
• Oshita, T;Watanabe, S;Toyohara, T;Kujirai, R;Kikuchi, K;Suzuki, T;Suzuki, C;Matsumoto, Y;Wada, J;Tomioka, Y;Tanaka, T;Abe, T; Urinary growth differentiation factor 15 predicts renal function decline in diabetic kidney disease Scientific reports 2023-08-02 [PMID: 37532799] (Human)
• Wang, D;Townsend, LK;DesOrmeaux, GJ;Frangos, SM;Batchuluun, B;Dumont, L;Kuhre, RE;Ahmadi, E;Hu, S;Rebalka, IA;Gautam, J;Jabile, MJT;Pileggi, CA;Rehal, S;Desjardins, EM;Tsakiridis, EE;Lally, JSV;Juracic, ES;Tupling, AR;Gerstein, HC;Paré, G;Tsakiridis, T;Harper, ME;Hawke, TJ;Speakman, JR;Blondin, DP;Holloway, GP;Jørgensen, SB;Steinberg, GR; GDF15 promotes weight loss by enhancing energy expenditure in muscle Nature 2023-07-01 [PMID: 37380764] (Human)
• S Yoshida, T Saito, K Shibagaki, K Hirao, T Yuza, N Tomosugi, H Honda Changes of biomarkers for erythropoiesis, iron metabolism, and FGF23 by supplementation with roxadustat in patients on hemodialysis Scientific Reports, 2023-02-23;13(1):3181. 2023-02-23 [PMID: 36823243] (Human)
• M Joo, D Kim, MW Lee, HJ Lee, JM Kim GDF15 Promotes Cell Growth, Migration, and Invasion in Gastric Cancer by Inducing STAT3 Activation International Journal of Molecular Sciences, 2023-02-02;24(3):. 2023-02-02 [PMID: 36769245] (Human)
• MS Binder, LR Yanek, W Yang, B Butcher, S Norgard, JE Marine, A Kolandaive, J Chrispin, NS Fedarko, H Calkins, B O'Rourke, KC Wu, GF Tomaselli, AS Barth Growth Differentiation Factor-15 Predicts Mortality and Heart Failure Exacerbation But Not Ventricular Arrhythmias in Patients With Cardiomyopathy Journal of the American Heart Association, 2023-01-31;12(3):e8023. 2023-01-31 [PMID: 36718879] (Human)
• JY Kim-Muller, L Song, B LaCarubba, E Pashos, X Li, A Rinaldi, S Joaquim, JC Stansfield, J Zhang, A Robertson, J Pang, A Opsahl, M Boucher, D Breen, K Hales, A Sheikh, Z Wu, BB Zhang GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia Cell Reports, 2023-01-10;42(1):111947. 2023-01-10 [PMID: 36640326] (Human)
• M Gherghe, AM Lazar, MD Mutuleanu, CI Bordea, S Ionescu, RI Mihaila, C Petroiu, AE Stanciu Evaluating Cardiotoxicity in Breast Cancer Patients Treated with HER2 Inhibitors: Could a Combination of Radionuclide Ventriculography and Cardiac Biomarkers Predict the Cardiac Impact? Cancers, 2022-12-29;15(1):. 2022-12-29 [PMID: 36612202] (Human)
• JS Quist, AB Klein, K Færch, K Beaulieu, M Rosenkilde, AS Gram, A Sjödin, S Torekov, B Stallknech, C Clemmensen, MB Blond Effects of acute exercise and exercise training on plasma GDF15 concentrations and associations with appetite and cardiometabolic health in individuals with overweight or obesity - A secondary analysis of a randomized controlled trial Appetite, 2022-12-21;182(0):106423. 2022-12-21 [PMID: 36563967] (Human)
• TE Peterson, C Landon, SA Haberlen, F Bhondoekha, MW Plankey, FJ Palella, DA Piggott, JB Margolick, TT Brown, WS Post, KC Wu Circulating biomarker correlates of left atrial size and myocardial extracellular volume fraction among persons living with and without HIV BMC cardiovascular disorders, 2022-09-03;22(1):393. 2022-09-03 [PMID: 36057773] (Human)
• L Wu, L Luo, L Zhou, N Li, X Qin GDF-15 and sST-2 act as biomarkers of disease severity but not independent predictors in idiopathic membranous nephropathy International immunopharmacology, 2022-08-24;111(0):109150. 2022-08-24 [PMID: 36027852] (Human)
• M Sugimoto, R Suzuki, Y Nozawa, T Takagi, N Konno, H Asama, Y Sato, H Irie, J Nakamura, M Takasumi, M Hashimoto, T Kato, R Kobashi, O Suzuki, Y Hashimoto, T Hikichi, H Ohira Clinical usefulness and acceleratory effect of macrophage inhibitory cytokine-1 on biliary tract cancer: an experimental biomarker analysis Cancer Cell International, 2022-08-10;22(1):250. 2022-08-10 [PMID: 35948981] (Human)
• Margalida Torrens-Mas, Catalina M. Perelló-Reus, Neus Trias-Ferrer, Lesly Ibargüen-González, Catalina Crespí, Aina Maria Galmes-Panades et al. GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility Frontiers in Cellular and Infection Microbiology 2022-07-22 [PMID: 35937703] (Human)
• J Luther, AG Vannier, EA Schaefer, RP Goodman The circulating proteomic signature of alcohol-associated liver disease JCI Insight, 2022-07-22;7(14):. 2022-07-22 [PMID: 35866482] (Human)
• H Kared, AS Wolf, A Alirezayla, A Ravussin, G Solum, TT Tran, F Lund-Johan, JT Vaage, LS Nissen-Mey, UC Nygaard, O Hungnes, AH Robertson, LM Næss, L Trogstad, P Magnus, LA Munthe, S Mjaaland Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults Nature Communications, 2022-07-18;13(1):4165. 2022-07-18 [PMID: 35851055] (Human)
• V Ananthapad, TC Frost, KM Soroko, A Knott, BJ Magliozzi, PC Gokhale, VG Tirunagaru, RC Doebele, JA DeCaprio Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma JCI Insight, 2022-07-08;7(13):. 2022-07-08 [PMID: 35801592] (Mouse)
• T Arinaga-Hi, T Ide, J Akiba, H Suzuki, R Kuwahara, K Amano, T Kawaguchi, T Sano, E Inoue, H Koga, K Mitsuyama, Y Koga, T Torimura Growth differentiation factor 15 as a novel diagnostic and therapeutic marker for autoimmune hepatitis Scientific Reports, 2022-05-24;12(1):8759. 2022-05-24 [PMID: 35610317] (Human)
• Y Wang, C Chen, J Chen, T Sang, H Peng, X Lin, Q Zhao, S Chen, T Eling, X Wang Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation Redox Biology, 2022-04-27;52(0):102322. 2022-04-27 [PMID: 35504134] (Human)
• H Yamamoto, F Takeshima, M Haraguchi, Y Akazawa, K Matsushima, M Kitayama, K Ogihara, M Tabuchi, K Hashiguchi, N Yamaguchi, H Miyaaki, H Kondo, K Nakao High serum concentrations of growth differentiation factor-15 and their association with Crohn's disease and a low skeletal muscle index Scientific Reports, 2022-04-21;12(1):6591. 2022-04-21 [PMID: 35449185] (Human)
• YS Cha, JS Chang, H Kim, KS Park Application of Mitochondrial and Oxidative Stress Biomarkers in the Evaluation of Neurocognitive Prognosis Following Acute Carbon Monoxide Poisoning Metabolites, 2022-02-24;12(3):. 2022-02-24 [PMID: 35323645] (Human)
• J Geppert, AA Walth, R Terrón Exp, D Kaltenecke, P Morigny, J Machado, M Becker, E Simoes, JDCC Lima, C Daniel, M Berriel Di, S Herzig, M Seelaender, M Rohm Aging Aggravates Cachexia in Tumor-Bearing Mice Cancers, 2021-12-24;14(1):. 2021-12-24 [PMID: 35008253] (Human)
• S Nawrocka-M, J Biegus, M Hurkacz, M Guzik, M Rosiek-Bie, EA Jankowska, P Ponikowski, R Zymli?ski Differences in the Biomarker Profile of De Novo Acute Heart Failure versus Decompensation of Chronic Heart Failure Biomolecules, 2021-11-16;11(11):. 2021-11-16 [PMID: 34827701] (Human)
• JR Herrmann, EL Fink, A Fabio, AK Au, RP Berger, K Janesko-Fe, RSB Clark, PM Kochanek, TC Jackson Serum levels of the cold stress hormones FGF21 and GDF-15 after cardiac arrest in infants and children enrolled in single center therapeutic hypothermia clinical trials Resuscitation, 2021-11-22;0(0):. 2021-11-22 [PMID: 34822938] (Human)
• CAZ de Sousa, APR Sierra, BS Martínez G, JFS Maciel, R Manoel, HV Barbeiro, HP de Souza, MF Cury-Boave Time Course and Role of Exercise-Induced Cytokines in Muscle Damage and Repair After a Marathon Race Frontiers in Physiology, 2021-10-15;12(0):752144. 2021-10-15 [PMID: 34721075] (Human)
• N Vallet, JB Delaye, M Ropert, A Foucault, N Ravalet, S Deriaz, T Chalopin, H Blasco, F Maillot, O Hérault, E Gyan Megaloblastic anemia-related iron overload and erythroid regulators: a case report Journal of medical case reports, 2021-09-20;15(1):463. 2021-09-20 [PMID: 34538261] (Human)
• JH Lim, Y Jeon, JS Ahn, S Kim, DK Kim, JP Lee, DR Ryu, EY Seong, SY Ahn, SH Baek, HY Jung, JY Choi, SH Park, CD Kim, YL Kim, JH Cho GDF-15 Predicts In-Hospital Mortality of Critically Ill Patients with Acute Kidney Injury Requiring Continuous Renal Replacement Therapy: A Multicenter Prospective Study Journal of Clinical Medicine, 2021-08-18;10(16):. 2021-08-18 [PMID: 34441955] (Human)
• P Lertpatipa, J Lee, I Kim, T Eling, SY Oh, JK Seong, SJ Baek The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice Scientific Reports, 2021-07-22;11(1):15027. 2021-07-22 [PMID: 34294853] (Mouse)
• Y Hong, J Lee, H Moon, CH Ryu, J Seok, YS Jung, J Ryu, SJ Baek Quercetin Induces Anticancer Activity by Upregulating Pro-NAG-1/GDF15 in Differentiated Thyroid Cancer Cells Cancers, 2021-06-16;13(12):. 2021-06-16 [PMID: 34208730] (Human)
• S Bauer, GD Demetri, E Halilovic, R Dummer, C Meille, DSW Tan, N Guerreiro, A Jullion, S Ferretti, S Jeay, L Van Bree, F Hourcade-P, JU Wuerthner, C Fabre, PA Cassier Pharmacokinetic-pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies British Journal of Cancer, 2021-06-17;0(0):. 2021-06-17 [PMID: 34140638] (Human)
• T Kato, T Nakajima, T Fukuda, I Shibasaki, T Hasegawa, K Ogata, H Ogawa, S Hirota, H Ohashi, S Saito, Y Takei, M Tezuka, M Seki, T Kuwata, M Sakuma, S Abe, S Toyoda, T Inoue, H Fukuda Preoperative Serum GDF-15, Endothelin-1 Levels, and Intraoperative Factors as Short-Term Operative Risks for Patients Undergoing Cardiovascular Surgery Journal of Clinical Medicine, 2021-05-02;10(9):. 2021-05-02 [PMID: 34063283] (Human)
• RLI Crake, MR Strother, E Phillips, MP Doogue, M Zhang, CMA Frampton, BA Robinson, MJ Currie Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: a patient feasibility study Scientific Reports, 2021-03-11;11(1):5648. 2021-03-11 [PMID: 33707475] (Human)
• C Bening, VL Sales, K Alhussini, D Radakovic, RC Benitez, N Madrahimov, D Keller, R Leyh Clinically inapparent right heart dysfunction is associated with reduced myofilament force development in coronary artery disease BMC cardiovascular disorders, 2021-03-05;21(1):125. 2021-03-05 [PMID: 33663396] (Human)
• H Liu, Y Huang, Y Lyu, W Dai, Y Tong, Y Li GDF15 as a biomarker of ageing Experimental gerontology, 2021-01-06;146(0):111228. 2021-01-06 [PMID: 33421539] (Human)
• M de Cos Gom, A Benito Her, MT Garcia Unz, J Mazon Ruiz, C Lopez Del, JL Perez Cang, D San Segund, R Valero San, JC Ruiz San M, E Rodrigo Ca Growth Differentiation Factor 15: A Biomarker with High Clinical Potential in the Evaluation of Kidney Transplant Candidates Journal of Clinical Medicine, 2020-12-20;9(12):. 2020-12-20 [PMID: 33419237] (Human)
• PG Guinot, O Ellouze, S Grosjean, V Berthoud, T Constandac, M Radhouani, JB Anciaux, S Aho-Glele, MC Morgant, C Girard, M Nguyen, B Bouhemad Anaesthesia and ICU sedation with sevoflurane do not reduce myocardial injury in patients undergoing cardiac surgery: A randomized prospective study Medicine, 2020-12-11;99(50):e23253. 2020-12-11 [PMID: 33327246] (Human)
• Y Oikawa, R Izumi, M Koide, Y Hagiwara, M Kanzaki, N Suzuki, K Kikuchi, T Matsuhashi, Y Akiyama, M Ichijo, S Watanabe, T Toyohara, T Suzuki, E Mishima, Y Akiyama, Y Ogata, C Suzuki, H Hayashi, EN Kodama, KI Hayashi, E Itoi, M Aoki, S Kure, T Abe Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5 PLoS ONE, 2020-12-02;15(12):e0231064. 2020-12-02 [PMID: 33264289] (Human)
• JO Chung, SY Park, DH Cho, DJ Chung, MY Chung Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes Sci Rep, 2020-11-25;10(1):20568. 2020-11-25 [PMID: 33239667] (Human)
• Z Zhao, J Zhang, L Yin, J Yang, Y Zheng, M Zhang, B Ni, H Wang Upregulated GDF-15 expression facilitates pancreatic ductal adenocarcinoma progression through orphan receptor GFRAL Aging (Albany NY), 2020-11-17;12(0):. 2020-11-17 [PMID: 33201838] (Human)
• H Wada, M Suzuki, M Matsuda, Y Ajiro, T Shinozaki, S Sakagami, K Yonezawa, M Shimizu, J Funada, T Takenaka, Y Morita, T Nakamura, K Fujimoto, H Matsubara, T Kato, T Unoki, D Takagi, K Wada, M Wada, M Iguchi, N Masunaga, M Ishii, H Yamakage, T Kusakabe, A Yasoda, A Shimatsu, K Kotani, N Satoh-Asah, M Abe, M Akao, K Hasegawa, ANOX Study Impact of Smoking Status on Growth Differentiation Factor 15 and Mortality in Patients With Suspected or Known Coronary Artery Disease: The ANOX Study J Am Heart Assoc, 2020-11-10;9(22):e018217. 2020-11-10 [PMID: 33170061] (Human)
• H Yazawa, T Fukuda, H Kaneda, R Waku, M Sakuma, A Matsumoto, S Toyoda, S Abe, F Nakamura, T Inoue, T Nakajima Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older females Int J Cardiol Heart Vasc, 2020-10-21;31(0):100651. 2020-10-21 [PMID: 33134478] (Human)
• DI Izaguirre, CW Ng, SY Kwan, EH Kun, YTM Tsang, DM Gershenson, KK Wong The Role of GDF15 in Regulating the Canonical Pathways of the Tumor Microenvironment in Wild-Type p53 Ovarian Tumor and Its Response to Chemotherapy Cancers (Basel), 2020-10-19;12(10):. 2020-10-19 [PMID: 33086658] (Mouse)
• H Kim, KM Kim, MJ Kang, S Lim Growth differentiation factor-15 as a biomarker for sarcopenia in aging humans and mice Exp Gerontol, 2020-10-16;142(0):111115. 2020-10-16 [PMID: 33069782] (Human)
• MA Hannappe, L Arnould, A Méloux, B Mouhat, F Bichat, M Zeller, Y Cottin, C Binquet, C Vergely, C Creuzot-Ga, C Guenancia Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients Sci Rep, 2020-10-07;10(1):16718. 2020-10-07 [PMID: 33028913] (Human)
• L Van Dyck, J Gunst, MP Casaer, B Peeters, I Derese, PJ Wouters, F de Zegher, I Vanhorebee, G Van den Be The clinical potential of GDF15 as a "ready-to-feed indicator" for critically ill adults Crit Care, 2020-09-14;24(1):557. 2020-09-14 [PMID: 32928255] (Human)
• DW Freeman, N Noren Hoot, Y Kim, NA Mode, N Ejiogu, AB Zonderman, MK Evans Association between GDF15, poverty and mortality in urban middle-aged African American and white adults PLoS ONE, 2020-08-07;15(8):e0237059. 2020-08-07 [PMID: 32764826] (Human)
• C Dominguez-, C Badosa, M Madruga-Ga, I Martí, C Paradas, C Ortez, J Diaz-Maner, A Berardo, J Alonso-Pér, S Trifunov, D Cuadras, SG Kalko, C Blázquez-B, Y Cámara, R Martí, F Mavillard, MA Martin, J Montoya, E Ruiz-Pesin, J Villarroya, R Montero, F Villarroya, R Artuch, M Hirano, A Nascimento, C Jimenez-Ma Growth Differentiation Factor 15 is a potential biomarker of therapeutic response for TK2 deficient myopathy Sci Rep, 2020-06-22;10(1):10111. 2020-06-22 [PMID: 32572108] (Human)
• T Borner, HS Wald, MY Ghidewon, B Zhang, Z Wu, BC De Jonghe, D Breen, HJ Grill GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss Cell Rep, 2020-04-21;31(3):107543. 2020-04-21 [PMID: 32320650] (Rat)
• VT Mitic, DR Stojanovic, MZ Deljanin I, MM Stojanovic, DB Petrovic, AM Ignjatovic, NZ Stefanovic, GM Kocic, VV Bojanic Cardiac Remodeling Biomarkers as Potential Circulating Markers of Left Ventricular Hypertrophy in Heart Failure with Preserved Ejection Fraction Tohoku J. Exp. Med., 2020-04-01;250(4):233-242. 2020-04-01 [PMID: 32295985] (Human)
• DF De Jesus, K Orime, D Kaminska, T Kimura, G Basile, CH Wang, L Haertle, R Riemens, NK Brown, J Hu, V Männistö, AM Silva, E Dirice, YH Tseng, T Haaf, J Pihlajamäk, RN Kulkarni Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice J. Clin. Invest., 2020-05-01;0(0):. 2020-05-01 [PMID: 32250344] (Human)
• Y Kagiyama, S Yatsuga, M Kinoshita, Y Koteda, S Kishimoto, Y Koga, K Suda Growth differentiation factor 15 as a useful biomarker of heart failure in young patients with unrepaired congenital heart disease of left to right shunt J Cardiol, 2019-12-26;0(0):. 2019-12-26 [PMID: 31883956] (Human)
• N Noren Hoot, MH McFarland, DW Freeman, NA Mode, N Ezike, AB Zonderman, MK Evans Association of Extracellular Vesicle Protein Cargo with Race and Clinical Markers of Mortality Sci Rep, 2019-11-26;9(1):17582. 2019-11-26 [PMID: 31772226] (Human)
• T Nakajima, I Shibasaki, T Sawaguchi, A Haruyama, H Kaneda, T Nakajima, T Hasegawa, T Arikawa, S Obi, M Sakuma, H Ogawa, S Toyoda, F Nakamura, S Abe, H Fukuda, T Inoue Growth Differentiation Factor-15 (GDF-15) is a Biomarker of Muscle Wasting and Renal Dysfunction in Preoperative Cardiovascular Surgery Patients J Clin Med, 2019-10-01;8(10):. 2019-10-01 [PMID: 31581569] (Human)
• Guangfu Chen, Min Wang, Xiang Liu GDF15 promotes osteosarcoma cell migration and invasion by regulating the TGF‑ beta signaling pathway Molecular Medicine Reports 2019-09-10 [PMID: 31545486] (Human)
• B Richter, T Uray, KA Krychtiuk, C Schriefl, M Lenz, A Nürnberger, SP Kastl, J Wojta, G Heinz, M Schwameis, WS Speidl Growth differentiation factor-15 predicts poor survival after cardiac arrest Resuscitation, 2019-08-05;143(0):22-28. 2019-08-05 [PMID: 31394153] (Human)
• A Miyauchi, T Kouga, EF Jimbo, T Matsuhashi, T Abe, T Yamagata, H Osaka Apomorphine rescues reactive oxygen species-induced apoptosis of fibroblasts with mitochondrial disease Mitochondrion, 2019-07-26;0(0):. 2019-07-26 [PMID: 31356884] (Human)
• L Traeger, I Ellermann, H Wiethoff, J Ihbe, I Gallitz, M Eveslage, R Moritz, E Herrmann, AJ Schrader, AU Steinbicke Serum Hepcidin and GDF-15 levels as prognostic markers in urothelial carcinoma of the upper urinary tract and renal cell carcinoma BMC Cancer, 2019-01-15;19(1):74. 2019-01-15 [PMID: 30646851] (Human)
• H Engerud, K Hope, HF Berg, KE Fasmer, IL Tangen, IS Haldorsen, J Trovik, C Krakstad Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer PLoS ONE, 2019-01-15;14(1):e0210585. 2019-01-15 [PMID: 30645608] (Human)
• CK Wu, MM Su, YF Wu, JJ Hwang, LY Lin Combination of Plasma Biomarkers and Clinical Data for the Detection of Myocardial Fibrosis or Aggravation of Heart Failure Symptoms in Heart Failure with Preserved Ejection Fraction Patients J Clin Med, 2018-11-08;7(11):. 2018-11-08 [PMID: 30413105] (Human)
• S Jeay, S Ferretti, P Holzer, J Fuchs, EA Chapeau, M Wartmann, D Sterker, V Romanet, M Murakami, G Kerr, EY Durand, S Gaulis, M Cortes-Cro, S Ruetz, TM Stachyra, J Kallen, P Furet, J Wuerthner, N Guerreiro, E Halilovic, A Jullion, A Kauffmann, E Kuriakose, M Wiesmann, MR Jensen, F Hofmann, WR Sellers Dose and schedule determine distinct molecular mechanisms underlying the efficacy of the p53-MDM2 inhibitor HDM201 Cancer Res., 2018-08-22;0(0):. 2018-08-22 [PMID: 30135191] (Human)
• L Sun, X Zhou, J Jiang, X Zang, X Chen, H Li, H Cao, Q Wang Growth differentiation factor-15 levels and the risk of contrast induced nephropathy in patients with acute myocardial infarction undergoing percutaneous coronary intervention: A retrospective observation study PLoS ONE, 2018-05-23;13(5):e0197609. 2018-05-23 [PMID: 29791474] (Human)
• A Babic, N Schnure, NP Neupane, MM Zaman, N Rifai, MW Welch, LK Brais, DA Rubinson, V Morales-Oy, C Yuan, S Zhang, EM Poole, BM Wolpin, MH Kulke, DA Barbie, K Wong, CS Fuchs, K Ng Plasma inflammatory cytokines and survival of pancreatic cancer patients Clin Transl Gastroenterol, 2018-04-25;9(4):145. 2018-04-25 [PMID: 29691365] (Human)
• YR Ham, CH Song, HJ Bae, JY Jeong, MK Yeo, DE Choi, KR Na, KW Lee Growth Differentiation Factor-15 as a Predictor of Idiopathic Membranous Nephropathy Progression: A Retrospective Study Dis. Markers, 2018-02-22;2018(0):1463940. 2018-02-22 [PMID: 29682097] (Human)
• S Li, YM Ma, PS Zheng, P Zhang GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2 J. Exp. Clin. Cancer Res., 2018-04-10;37(1):80. 2018-04-10 [PMID: 29636108] (Human)
• R Scherzer, SJ Shah, E Secemsky, J Butler, C Grunfeld, MG Shlipak, PY Hsue Association of Biomarker Clusters With Cardiac Phenotypes and Mortality in Patients With HIV Infection Circ Heart Fail, 2018-04-01;11(4):e004312. 2018-04-01 [PMID: 29615435] (Human)
• L Sun, X Zhou, J Jiang, X Zang, X Chen, H Li, H Cao, Q Wang Growth differentiation factor-15 levels and the risk of contrast induced acute kidney injury in acute myocardial infarction patients treated invasively: A propensity-score match analysis PLoS ONE, 2018-03-12;13(3):e0194152. 2018-03-12 [PMID: 29529072] (Human)
• M Kleinert, C Clemmensen, KA Sjøberg, CS Carl, JF Jeppesen, JFP Wojtaszews, B Kiens, EA Richter Exercise increases circulating GDF15 in humans Mol Metab, 2018-01-17;0(0):. 2018-01-17 [PMID: 29398617] (Human)
• S Stojkovic, A Kaider, L Koller, M Brekalo, J Wojta, A Diedrich, S Demyanets, T Pezawas GDF-15 is a better complimentary marker for risk stratification of arrhythmic death in non-ischaemic, dilated cardiomyopathy than soluble ST2 J. Cell. Mol. Med., 2018-02-04;0(0):. 2018-02-04 [PMID: 29397580] (Human)
• L Buendgens, E Yagmur, J Bruensing, U Herbers, C Baeck, C Trautwein, A Koch, F Tacke Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis Dis. Markers, 2017-10-18;2017(0):5271203. 2017-10-18 [PMID: 29180833] (Human)
• NM Ratnam, JM Peterson, EE Talbert, KJ Ladner, PV Rajasekera, CR Schmidt, ME Dillhoff, BJ Swanson, E Haverick, RD Kladney, TM Williams, GW Leone, DJ Wang, DC Guttridge NF-?B regulates GDF-15 to suppress macrophage surveillance during early tumor development J. Clin. Invest., 2017-09-11;0(0):. 2017-09-11 [PMID: 28891811] (Human)
• M Sugimoto, T Takagi, N Konno, R Suzuki, H Asama, K Watanabe, J Nakamura, Y Waragai, H Kikuchi, M Takasumi, Y Sato, T Hikichi, H Ohira The efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer Sci Rep, 2017-08-23;7(1):9198. 2017-08-23 [PMID: 28835660] (Human)
• T Matsuhashi, T Sato, SI Kanno, T Suzuki, A Matsuo, Y Oba, M Kikusato, E Ogasawara, T Kudo, K Suzuki, O Ohara, H Shimbo, F Nanto, H Yamaguchi, D Saigusa, Y Mukaiyama, A Watabe, K Kikuchi, H Shima, E Mishima, Y Akiyama, Y Oikawa, HO Hsin-Jung, Y Akiyama, C Suzuki, M Uematsu, M Ogata, N Kumagai, M Toyomizu, A Hozawa, N Mano, Y Owada, S Aiba, T Yanagisawa, Y Tomioka, S Kure, S Ito, K Nakada, KI Hayashi, H Osaka, T Abe Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases EBioMedicine, 2017-05-13;0(0):. 2017-05-13 [PMID: 28579242] (Human)
• N Ban, CJ Siegfried, JB Lin, YB Shui, J Sein, W Pita-Thoma, A Sene, A Santeford, M Gordon, R Lamb, Z Dong, SC Kelly, V Cavalli, J Yoshino, RS Apte GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients JCI Insight, 2017-05-04;2(9):. 2017-05-04 [PMID: 28469085] (Human)
• Y Yang, S Lian, L Meng, L Qu, C Shou Antibody Array Revealed PRL-3 Affects Protein Phosphorylation and Cytokine Secretion PLoS ONE, 2017-01-09;12(1):e0169665. 2017-01-09 [PMID: 28068414] (Human)
• Marie Helene Schernthan Growth differentiation factor 15 increases following oral glucose ingestion: effect of meal composition and obesity Eur. J. Endocrinol, 2016-12-01;175(6):623-631. 2016-12-01 [PMID: 27926473] (Human)
• Zhize Yuan Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pump coronary artery bypass grafting Sci Rep, 2016-06-17;6(0):28221. 2016-06-17 [PMID: 27311391] (Human)
• Mahon K, Lin H, Castillo L, Lee B, Lee-Ng M, Chatfield M, Chiam K, Breit S, Brown D, Molloy M, Marx G, Pavlakis N, Boyer M, Stockler M, Daly R, Henshall S, Horvath L Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer. Br J Cancer, 2015-03-31;112(8):1340-8. 2015-03-31 [PMID: 25867259] (Human)
• Urakawa , Naoki, Utsunomiya , Soken, Nishio , Mari, Shigeoka , Manabu, Takase , Nobuhisa, Arai , Noriaki, Kakeji , Yoshihir, Koma , Yu-Ichir, Yokozaki , Hiroshi GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways. Lab Invest, 2015-03-02;95(5):491-503. 2015-03-02 [PMID: 25730371] (Human)
• Jeansonne D, DeLuca M, Marrero L, Lassak A, Pacifici M, Wyczechowska D, Wilk A, Reiss K, Peruzzi F Anti-tumoral effects of miR-3189-3p in glioblastoma. J Biol Chem, 2015-02-02;290(13):8067-80. 2015-02-02 [PMID: 25645911] (Human)
• Kahli A, Guenancia C, Zeller M, Grosjean S, Stamboul K, Rochette L, Girard C, Vergely C Growth differentiation factor-15 (GDF-15) levels are associated with cardiac and renal injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. PLoS ONE, 2014-08-29;9(8):e105759. 2014-08-29 [PMID: 25171167] (Human)
• Fujiwara , Tohru, Ikeda , Takashi, Nagasaka , Yuki, Okitsu , Yoko, Katsuoka , Yuna, Fukuhara , Noriko, Onishi , Yasushi, Ishizawa , Kenichi, Ichinohasama , Ryo, Tomosugi , Naohisa, Harigae , Hideo A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. PLoS ONE, 2013-09-27;8(9):e75568. 2013-09-27 [PMID: 24086573] (Human)
• Andre T, Meuleman N, Stamatopoulos B, De Bruyn C, Pieters K, Bron D, Lagneaux L Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cells. PLoS ONE, 2013-03-21;8(3):e59756. 2013-03-21 [PMID: 23555770] (Human)
• Bone marrow mesenchymal stem cells in patients with beta thalassemia major: molecular analysis with attenuated total reflection-Fourier transform infrared spectroscopy study as a novel method. Stem Cells Dev., 2012-02-15;21(11):2000-11. 2012-02-15 [PMID: 22214206] (Human)
• Talbot NP, Lakhal S, Smith TG, Privat C, Nickol AH, Rivera-Ch M, Leon-Velarde F, Dorrington KL, Mole DR, Robbins PA Regulation of hepcidin expression at high altitude. Blood, 2011-11-30;119(3):857-60. 2011-11-30 [PMID: 22130801] (Human)
• Si Y, Liu X, Cheng M, Wang M, Gong Q, Yang Y, Wang T, Yang W Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes. PLoS ONE, 2011-05-23;6(5):e19967. 2011-05-23 [PMID: 21625435] (Human)
• Wei J, Wu A, Kong LY, Wang Y, Fuller G, Fokt I, Melillo G, Priebe W, Heimberger AB Hypoxia potentiates glioma-mediated immunosuppression. PLoS ONE, 2011-01-20;6(1):e16195. 2011-01-20 [PMID: 21283755] (Human)
• Vila G, Riedl M, Anderwald C, Resl M, Handisurya A, Clodi M, Prager G, Ludvik B, Krebs M, Luger A The relationship between insulin resistance and the cardiovascular biomarker growth differentiation factor-15 in obese patients. Clin. Chem., 2010-12-16;57(2):309-16. 2010-12-16 [PMID: 21164037] (Human)
• Piperno A, Galimberti S, Mariani R Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood, 2010-12-13;117(10):2953-9. 2010-12-13 [PMID: 21149632] (Human)
• Darmanis S, Nong RY, Hammond M, Gu J, Alderborn A, Vanelid J, Siegbahn A, Gustafsdottir S, Ericsson O, Landegren U, Kamali-Moghaddam M Sensitive plasma protein analysis by microparticle-based proximity ligation assays. Mol. Cell Proteomics, 2009-11-27;9(2):327-35. 2009-11-27 [PMID: 19955079] (Human)
• Ashby DR, Gale DP, Busbridge M, Murphy KG, Duncan ND, Cairns TD, Taube DH, Bloom SR, Tam FW, Chapman RS, Maxwell PH, Choi P Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease. Kidney Int., 2009-02-11;75(9):976-81. 2009-02-11 [PMID: 19212416] (Human)

Bioinformatics

• Gene Symbol: GDF15