Human/Cynomolgus Monkey PD-L1/B7-H1 QuicKit ELISA

• Reactivity: Hu, Pm-Cm
• Conjugate: HRP

Human/Cynomolgus Monkey PD-L1/B7-H1 QuicKit ELISA Summary

• Background: The Quantikine QuicKit Human/Cynomolgus Monkey PD-L1/B7-H1 Immunoassay is a one-step, 80-minute solid phase ELISA designed to measure human/cynomolgus monkey PD-L1/B7-H1 levels in cell culture supernates, serum, plasma, cell lysates, and urine. It contains recombinant human PD-L1/B7-H1 and antibodies raised against the recombinant protein. Results obtained for naturally occurring human/cynom...olgus monkey PD-L1/B7-H1 showed linear curves that were parallel to the standard curves obtained using the recombinant QuicKit standards. These results indicate that this kit can be used to determine relative mass values for natural human/cynomolgus monkey PD-L1/B7-H1.
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• Additional Information: Human/Cynomolgus Monkey PD-L1/B7-H1 QuicKit ELISA
• Specificity: Natural and recombinant human PD-L1/B7-H1 and natural cynomolgus monkey PD-L1/B7-H1.
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human/Cynomolgus Monkey PD-L1/B7-H1 QuicKit ELISA

• Avelumab
• B7-H
• B7H1
• B7-H1
• B7H1PDCD1L1
• CD274 antigenMGC142294
• CD274 molecule
• CD274
• PDCD1L1
• PDCD1LG1
• PDCD1LG1MGC142296
• PDL1
• PD-L1
• PD-L1B7 homolog 1
• PDL1PDCD1 ligand 1
• programmed cell death 1 ligand 1
• Programmed death ligand 1

Background

PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. PD-L1 binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells.

FAQs for PD-L1 (QK1146). (Showing 1 - 1 of 1 FAQ).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.