Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit Summary

Background
The Quantikine Human BLC/BCA-1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human BLC/BCA-1 in cell culture supernates, serum, plasma, and saliva. It contains E. coli-expressed recombinant human BLC/BCA-1 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human BLC/BCA-1 showed linear curves that were parallel to the... standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring BLC/BCA-1.
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Specificity
Natural and recombinant human BLC/BCA-1
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CXCL13

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DCX130.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit

  • ANGIE
  • ANGIE2
  • B cell-attracting chemokine 1
  • B lymphocyte chemoattractant
  • BCA1
  • BCA-1
  • BCA1B-cell chemoattractant
  • BCA-1CXC chemokine BLC
  • B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)
  • BLC
  • BLCSmall-inducible cytokine B13
  • BLR1L
  • B-lymphocyte chemoattractant
  • chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
  • chemokine (C-X-C motif) ligand 13
  • C-X-C motif chemokine 13
  • CXCL13
  • SCYB13
  • SCYB13B-cell-attracting chemokine 1
  • small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)

Background

CXCL13/BLC/BCA-1 is a constitutively expressed chemokine that plays an important role in B and T cell homing. It is expressed by salivary gland epithelium, dendritic cells, osteoclasts, and peritoneal macrophages. It can form homodimers or heterodimers with FGF basic, and it signals through CXCR3 or CXCR5. CXCL13 induces the migration of naïve B cells and a subset of memory T cells to lymphoid tissue. It also promotes B1 cell migration into the omentum and peritoneum. In the fetus, CXCL13 attracts CD4+ CD3- IL-7 R alpha+ hematopoietic cells to sites of future Peyer’s patch development.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CXCL13/BLC/BCA-1 (DCX130)(46)

We have publications tested in 1 confirmed species: Human.


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Human
(46)
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Showing Publications 1 - 10 of 46. Show All 46 Publications.
Publications using DCX130 Applications Species
SK Pierson, L Katz, R Williams, M Mumau, M Gonzalez, S Guzman, A Rubenstein, AB Oromendia, P Beineke, A Fosså, F van Rhee, DC Fajgenbaum CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease Nature Communications, 2022;13(1):7236. 2022 [PMID: 36433996] (Human) Human
J Ruder, G Dinner, A Maceski, E Berenjeno-, AM Müller, I Jelcic, J Kuhle, R Martin Dynamics of Inflammatory and Neurodegenerative Biomarkers after Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis International Journal of Molecular Sciences, 2022;23(18):. 2022 [PMID: 36142860] (Human) Human
AG Goubet, L Lordello, C Alves Cost, I Peguillet, M Gazzano, MD Mbogning-F, C Thelemaque, C Lebacle, C Thibault, F Audenet, G Pignot, G Gravis, C Helissey, L Campedel, M Roupret, E Xylinas, I Ouzaid, A Dubuisson, M Mazzenga, C Flament, P Ly, V Marty, N Signolle, A Sauvat, T Sbarrato, M Filahi, C Davin, G Haddad, J Bou Khalil, C Bleriot, FX Danlos, G Dunsmore, K Mulder, A Silvin, T Raoult, B Archambaud, S Belhechmi, I Gomperts B, N Cayet, M Moya-Nilge, A Mallet, R Daillere, E Rouleau, C Radulescu, Y Allory, J Fieschi, M Rouanne, F Ginhoux, G Le Teuff, L Derosa, A Marabelle, J VAN Dorp, N VAN Dijk, MS van der He, B Besse, F Andre, M Merad, G Kroemer, JY Scoazec, L Zitvogel, Y Loriot Escherichia coli-specific CXCL13-producing TFH are associated with clinical efficacy of neoadjuvant PD-1 blockade against muscle-invasive bladder cancer Cancer Discovery, 2022;0(0):. 2022 [PMID: 35929803] (Human) Human
J Jeon, J Park, HJ Boo, KE Yang, CJ Lee, JE Lee, K Kim, GY Kwon, W Huh, DJ Kim, YG Kim, HR Jang Clinical value of urinary cytokines/chemokines as prognostic markers in patients with crescentic glomerulonephritis Oncogene, 2022;12(1):10221. 2022 [PMID: 35715470] (Human) Human
M Ukita, J Hamanishi, H Yoshitomi, K Yamanoi, S Takamatsu, A Ueda, H Suzuki, Y Hosoe, Y Furutake, M Taki, K Abiko, K Yamaguchi, H Nakai, T Baba, N Matsumura, A Yoshizawa, H Ueno, M Mandai CXCL13-producing CD4+ T cells accumulate in early phase of tertiary lymphoid structures in ovarian cancer JCI Insight, 2022;0(0):. 2022 [PMID: 35552285] (Human) Human
BS Cox, K Alharshawi, I Mena-Palom, WP Lafuse, ME Ariza EBV/HHV-6A dUTPases contribute to myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology by enhancing TFH cell differentiation and extrafollicular activities JCI Insight, 2022;7(11):. 2022 [PMID: 35482424] (Human) Human
T Robinson, A Abdelhak, T Bose, E Meinl, M Otto, UK Zettl, R Dersch, H Tumani, S Rauer, A Huss Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis Cells, 2020;9(12):. 2020 [PMID: 33255854] (Human) Human
M Sivina, L Xiao, E Kim, A Vaca, SS Chen, MJ Keating, A Ferrajoli, Z Estrov, N Jain, WG Wierda, X Huang, N Chiorazzi, JA Burger CXCL13 plasma levels function as a biomarker for disease activity in patients with chronic lymphocytic leukemia Leukemia, 2020;0(0):. 2020 [PMID: 33087831] (Human) Human
P Körtvelyes, A Goihl, K Guttek, B Schraven, H Prüss, D Reinhold Serum and CSF cytokine levels mirror different neuroimmunological mechanisms in patients with LGI1 and Caspr2 encephalitis Cytokine, 2020;135(0):155226. 2020 [PMID: 32799011] (Human) Human
F Saberi Hos, PM Kolijn, D Casabonne, A Nieters, M Solans, S Naudin, P Ferrari, JD Mckay, E Weiderpass, V Perduca, C Besson, FR Mancini, G Masala, V Krogh, F Ricceri, JM Huerta, D Petrova, N Sala, A Trichopoul, A Karakatsan, C La Vecchia, R Kaaks, F Canzian, D Aune, H Boeing, MB Schulze, A Perez-Corn, AW Langerak, VHJ van der Ve, R Vermeulen Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development Sci Rep, 2020;10(1):13814. 2020 [PMID: 32796953] (Human) Human
Show All 46 Publications.

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Bioinformatics

Gene Symbol CXCL13