Human CXCL13/BLC/BCA-1 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human CXCL13/BLC/BCA-1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CXCL13

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CXCL13/BLC/BCA-1 DuoSet ELISA, 15 Plate

• ANGIE
• ANGIE2
• B cell-attracting chemokine 1
• B lymphocyte chemoattractant
• BCA1
• BCA-1
• BCA1B-cell chemoattractant
• BCA-1CXC chemokine BLC
• B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)
• BLC
• BLCSmall-inducible cytokine B13
• BLR1L
• B-lymphocyte chemoattractant
• chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
• chemokine (C-X-C motif) ligand 13
• C-X-C motif chemokine 13
• CXCL13
• SCYB13
• SCYB13B-cell-attracting chemokine 1
• small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)

Background

CXCL13/BLC/BCA-1 is a constitutively expressed chemokine that plays an important role in B and T cell homing. It is expressed by salivary gland epithelium, dendritic cells, osteoclasts, and peritoneal macrophages. It can form homodimers or heterodimers with FGF basic, and it signals through CXCR3 or CXCR5. CXCL13 induces the migration of naïve B cells and a subset of memory T cells to lymphoid tissue. It also promotes B1 cell migration into the omentum and peritoneum. In the fetus, CXCL13 attracts CD4+ CD3- IL-7 R alpha+ hematopoietic cells to sites of future Peyer’s patch development.

Publications for CXCL13/BLC/BCA-1 (DY801)(18)

Publications using DY801

• Courtemanche, O;Huppé, CA;Blais-Lecours, P;Maranda, C;Morissette, MC;Blanchet, MR;Dion, G;Marsolais, D; Ex Vivo Overactivation of Lymphocyte Subsets in Fibrotic Hypersensitivity Pneumonitis Is Blunted by a Sphingosine-1-Phosphate Receptor Ligand International journal of molecular sciences 2025-03-29 [PMID: 40243992] (Human)
• Rouanne, M;Chen, N;Mariuzza, DL;Li, F;de Los Santos-Alexis, K;Savage, TM;Vincent, RL;Mendelsohn, CL;Danino, T;Arpaia, N; Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy bioRxiv : the preprint server for biology 2024-10-29 [PMID: 39554157] (E. coli)
• Law, C;Wacleche, VS;Cao, Y;Pillai, A;Sowerby, J;Hancock, B;Horisberger, A;Bracero, S;Skidanova, V;Li, Z;Adejoorin, I;Dillon, E;Benque, IJ;Nunez, DP;Simmons, DP;Keegan, J;Chen, L;Baker, T;Brohawn, PZ;Al-Mossawi, H;Hao, LY;Jones, B;Rao, N;Qu, Y;Alves, SE;Accelerating Medicines Partnership: RA/SLE Network, ;Jonsson, AH;Shaw, KS;Vleugels, RA;Massarotti, E;Costenbader, KH;Brenner, MB;Lederer, JA;Hultquist, JF;Choi, J;Rao, DA; Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus Nature 2024-07-10 [PMID: 38987586] (Human)
• Cencioni, MT;Magliozzi, R;Palmisano, I;Suwan, K;Mensi, A;Fuentes-Font, L;Villar, LM;Fernández-Velasco, JI;Migallón, NV;Costa-Frossard, L;Monreal, E;Ali, R;Romozzi, M;Mazarakis, N;Reynolds, R;Nicholas, R;Muraro, PA; Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis Journal of neuroinflammation 2024-04-12 [PMID: 38609999] (Human)
• Grabarczyk, M;Ksiazek-Winiarek, D;Glabinski, A;Szpakowski, P; Dietary Polyphenols Decrease Chemokine Release by Human Primary Astrocytes Responding to Pro-Inflammatory Cytokines Pharmaceutics 2023-09-07 [PMID: 37765263] (Human)
• Callum McKenzie, Mohamed El-Kholy, Farhaan Parekh, Mathew Robson, Katarina Lamb, Christopher Allen et al. Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy Molecular Therapy - Nucleic Acids 2023-06-13 [PMID: 37200859] (Human)
• H Asashima, S Mohanty, M Comi, WE Ruff, KB Hoehn, P Wong, J Klein, C Lucas, I Cohen, S Coffey, N Lele, L Greta, K Raddassi, O Chaudhary, A Unterman, B Emu, SH Kleinstein, RR Montgomery, A Iwasaki, CS Dela Cruz, N Kaminski, AC Shaw, DA Hafler, TS Sumida PD-1highCXCR5-CD4+ peripheral helper T�cells promote CXCR3+ plasmablasts in human acute viral infection Cell Reports, 2023-01-02;0(0):111895. 2023-01-02 [PMID: 36596303] (Human)
• W Alturaiki, H Alkadi, S Alamri, ME Awadalla, A Alfaez, A Mubarak, MA Alanazi, FQ Alenzi, BF Flanagan, B Alosaimi Association between the expression of Toll-like receptors, cytokines, and homeostatic chemokines in SARS-CoV-2 infection and COVID-19 severity Heliyon, 2022-12-24;0(0):e12653. 2022-12-24 [PMID: 36589720] (Human)
• P Szpakowski, D Ksiazek-Wi, M Turniak-Ku, I Pacan, A Glabinski Human Primary Astrocytes Differently Respond to Pro- and Anti-Inflammatory Stimuli Biomedicines, 2022-07-22;10(8):. 2022-07-22 [PMID: 35892669] (Human)
• CL Kemmerer, J Schittenhe, E Dubois, L Neumann, LM Häsler, M Lambert, M Renovanz, SA Kaeser, G Tabatabai, U Ziemann, U Naumann, MC Kowarik Cerebrospinal fluid cytokine levels are associated with macrophage infiltration into tumor tissues of glioma patients BMC Cancer, 2021-10-15;21(1):1108. 2021-10-15 [PMID: 34654395] (Human)
• T Koudstaal, D van Uden, JAC van Hulst, P Heukels, IM Bergen, LW Geenen, VJM Baggen, AE van den Bo, LM van den To, PP Chandoesin, M Kool, E Boersma, RW Hendriks, KA Boomars Plasma markers in pulmonary hypertension subgroups correlate with patient survival Respiratory Research, 2021-05-04;22(1):137. 2021-05-04 [PMID: 33947407] (Human)
• Activin A programs the differentiation of human TFH cells Nat Immunol, 2016-07-04;17(8):976-84. 2016-07-04 [PMID: 27376469] (Human)
• Kobayashi S, Watanabe T, Suzuki R, Furu M, Ito H, Ito J, Matsuda S, Yoshitomi H TGF-beta induces the differentiation of human CXCL13-producing CD4(+) T cells. Eur J Immunol, 2015-11-24;46(2):360-71. 2015-11-24 [PMID: 26541894] (Human)
• Edwards , Keith R, Goyal , Jaya, Plavina , Tatiana, Czerkowicz , Julie, Goelz , Susan, Ranger , Ann, Cadavid , Diego, Browning , Jeffrey Feasibility of the use of combinatorial chemokine arrays to study blood and CSF in multiple sclerosis. PLoS ONE, 2013-11-20;8(11):e81007. 2013-11-20 [PMID: 24278364] (Human)
• Kuenz B, Lutterotti A, Ehling R, Gneiss C, Haemmerle M, Rainer C, Deisenhammer F, Schocke M, Berger T, Reindl M Cerebrospinal fluid B cells correlate with early brain inflammation in multiple sclerosis. PLoS ONE, 2008-07-02;3(7):e2559. 2008-07-02 [PMID: 18596942] (Human)
• Vermijlen D, Ellis P, Langford C, Klein A, Engel R, Willimann K, Jomaa H, Hayday AC, Eberl M Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. J. Immunol., 2007-04-01;178(7):4304-14. 2007-04-01 [PMID: 17371987] (Human)
• Estes JD, Thacker TC, Hampton DL, Kell SA, Keele BF, Palenske EA, Druey KM, Burton GF Follicular dendritic cell regulation of CXCR4-mediated germinal center CD4 T cell migration. J. Immunol., 2004-11-15;173(10):6169-78. 2004-11-15 [PMID: 15528354] (Human)
• Perrier P, Martinez FO, Locati M, Bianchi G, Nebuloni M, Vago G, Bazzoni F, Sozzani S, Allavena P, Mantovani A Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13. J. Immunol., 2004-06-01;172(11):7031-42. 2004-06-01 [PMID: 15153525] (Human)

FAQs for CXCL13/BLC/BCA-1 (DY801). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: CXCL13