Human Chitinase 3-like 1/YKL-40 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Chitinase 3-like 1/YKL-40 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CHI3L1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Chitinase 3-like 1/YKL-40 DuoSet ELISA, 15 Plate

• AW208766
• Brp39
• CHI3L1
• Chitinase 3 like 1
• Chitinase 3-like 1
• gp39
• HCgp39
• YKL-40

Background

Chitinase 3-like 1 (CHI3L1), also called BRP39 in mouse or YKL-40 in humans, is a 39 kDa glycoprotein member of the glycosyl hydrolase 18 family although it does not show chitotriosidase activity. CHI3L1 is expressed by articular chondrocytes, synovial cells, activated monocyte-derived macrophages, neutrophils, endothelial cells, vascular smooth muscle cells, and some cancer cells. CHI3L1 binds to chitin and heparins, and it enhances cell adhesion, proliferation and tumor angiogenesis. Circulating CHI3L1 is elevated during inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. It is frequently upregulated in glioblastoma, myxoid chondrosarcoma, melanoma and carcinomas of the breast, thyroid, colon, lung, kidney, and ovary.

Publications for Chitinase 3-like 1/YKL-40 (DY2599)(12)

Publications using DY2599

• Wang, P;Yang, L;Dong, J;Liu, W;Xie, F;Lu, Y;Li, W; The sEVs miR-487a/Notch2/GATA3 axis promotes osteosarcoma lung metastasis by inducing macrophage polarization toward the M2-subtype Cancer cell international 2024-08-31 [PMID: 39217351] (Human)
• R Urbanavi?i, R Zabitait?, A Kriš?iukai, VP Deltuva, D Skiriut? Serum protein triplet TGF-&beta1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma Scientific Reports, 2021-06-23;11(1):13100. 2021-06-23 [PMID: 34162919] (Human)
• K Hübner, D Karwelat, E Pietsch, I Beinborn, S Winterberg, K Bedenbende, BJ Benedikter, B Schmeck, E Vollmeiste NF-kappaB-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cells Cell. Signal., 2019-12-16;67(0):109498. 2019-12-16 [PMID: 31837465] (Human)
• CR McDonald, AM Weckman, AL Conroy, P Olwoch, P Natureeba, MR Kamya, DV Havlir, G Dorsey, KC Kain Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole Sci Rep, 2019-05-01;9(1):6758. 2019-05-01 [PMID: 31043691] (Human)
• AL Conroy, MT Hawkes, R Elphinston, RO Opoka, S Namasopo, C Miller, CC John, KC Kain Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria Malar. J., 2018-02-15;17(1):82. 2018-02-15 [PMID: 29448936] (Human)
• Erdman L, D'Acremont V, Hayford K, Rajwans N, Kilowoko M, Kyungu E, Hongoa P, Alamo L, Streiner D, Genton B, Kain K Biomarkers of Host Response Predict Primary End-Point Radiological Pneumonia in Tanzanian Children with Clinical Pneumonia: A Prospective Cohort Study. PLoS ONE, 2015-09-14;10(9):e0137592. 2015-09-14 [PMID: 26366571] (Human)
• McDonald C, Darling A, Conroy A, Tran V, Cabrera A, Liles W, Wang M, Aboud S, Urassa W, Fawzi W, Kain K Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women. PLoS ONE, 2015-08-06;10(8):e0134619. 2015-08-06 [PMID: 26247200] (Human)
• Bouvet G, Maignan M, Arslanian E, Coriati A, Rabasa-Lhoret R, Berthiaume Y Association between serum YKL-40 level and dysglycemia in cystic fibrosis. Cytokine, 2014-12-11;71(2):296-301. 2014-12-11 [PMID: 25497736] (Human)
• Erdman , Laura K, Petes , Carlene, Lu , Ziyue, Dhabangi , Aggrey, Musoke , Charles, Cserti-Gazdewich , Christin, Lee , Chun Geu, Liles , Wayne Co, Elias , Jack A, Kain , Kevin C Chitinase 3-like 1 is induced by Plasmodium falciparum malaria and predicts outcome of cerebral malaria and severe malarial anaemia in a case-control study of African children. Malar J, 2014-07-21;13(0):279. 2014-07-21 [PMID: 25047113] (Human)
• Conroy A, Gelvez M, Hawkes M, Rajwans N, Liles W, Villar-Centeno L, Kain K Host biomarkers distinguish dengue from leptospirosis in Colombia: a case-control study. BMC Infect Dis, 2014-01-20;14(0):35. 2014-01-20 [PMID: 24444080] (Human)
• Appleby , Laura J, Nausch , Norman, Bourke , Claire D, Rujeni , Nadine, Midzi , Nicholas, Mduluza , Takafira, Allen , Judith E, Mutapi , Francisc Chitinase 3-like 1 protein levels are elevated in Schistosoma haematobium infected children. PLoS Negl Trop Dis, 2012-11-08;6(11):e1898. 2012-11-08 [PMID: 23145202] (Human)
• Choi J, Lee HW Plasma level of chitinase 3-like 1 protein increases in patients with early Alzheimer's disease. J. Neurol., 2011-05-12;0(0):. 2011-05-12 [PMID: 21562723] (Human)

Bioinformatics

• Gene Symbol: CHI3L1