HTRA1/PRSS11 Antibody (275615)

Images

 
Western blot shows lysates of human placenta tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human HTRA1/PRSS11 Monoclonal Antibody (Catalog # MAB2916) followed by HRP-conjugated Anti-Mouse IgG Secondary ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clone
275615
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

HTRA1/PRSS11 Antibody (275615) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human HTRA1/PRSS11
Gln23-Pro480
Accession # Q92743
Specificity
Detects human HTRA1/PRSS11 in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
HTRA1
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunoprecipitation 25 ug/mL
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB2916 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for HTRA1/PRSS11 Antibody (275615)

  • ARMD7
  • EC 3.4.21
  • EC 3.4.21.108
  • High-temperature requirement A serine peptidase 1
  • HtrA serine peptidase 1
  • HTRA1
  • IGFBP5-protease
  • L56
  • ORF480
  • PRSS11
  • Serine protease 11
  • serine, 11 (IGF binding)

Background

HTRA1 is a serine protease encoded by the PRSS11 gene and is expressed in many tissues. HTRA1 regulates the availability of IGFs by cleaving IGFBPs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for HTRA1/PRSS11 Antibody (MAB2916)(11)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ICC, IHC, Immunoprecipitation, Western Blot.


Filter By Application
ICC
(1)
IHC
(1)
Immunoprecipitation
(2)
Western Blot
(6)
All Applications
Filter By Species
Human
(8)
Mouse
(2)
All Species
Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using MAB2916 Applications Species
D Inoue, GL Chew, B Liu, BC Michel, J Pangallo, AR D'Avino, T Hitchman, K North, SC Lee, L Bitner, A Block, AR Moore, A Yoshimi, L Escobar-Ho, H Cho, A Penson, SX Lu, J Taylor, Y Chen, C Kadoch, O Abdel-Waha, RK Bradley Spliceosomal disruption of the non-canonical BAF complex in cancer Nature, 2019;0(0):. 2019 [PMID: 31597964] (Western Blot, Mouse) Western Blot Mouse
DC Hondius, KN Eigenhuis, THJ Morrema, RC van der Sc, P van Nierop, M Bugiani, KW Li, JJM Hoozemans, AB Smit, AJM Rozemuller Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer's disease Acta Neuropathol Commun, 2018;6(1):46. 2018 [PMID: 29860944] (IHC, Human) IHC Human
S Yamawaki, M Naitoh, H Kubota, R Aya, Y Katayama, T Ishiko, T Tamura, K Yoshikawa, T Enoshiri, M Ikeda, S Suzuki HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development Int J Mol Sci, 2018;19(5):. 2018 [PMID: 29695130] (Western Blot, Human) Western Blot Human
O Globus, T Evron, M Caspi, R Siman-Tov, R Rosin-Arbe High-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling Sci Rep, 2017;7(1):17995. 2017 [PMID: 29269789] (Western Blot, Human) Western Blot Human
E Melo, P Oertle, C Trepp, H Meisterman, T Burgoyne, L Sborgi, AC Cabrera, CY Chen, JC Hoflack, T Kam-Thong, R Schmucki, L Badi, N Flint, ZE Ghiani, F Delobel, C Stucki, G Gromo, A Einhaus, B Hornsperge, S Golling, J Siebourg-P, F Gerber, B Bohrmann, C Futter, T Dunkley, S Hiller, O Schilling, V Enzmann, S Fauser, M Plodinec, R Iacone HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model EBioMedicine, 2017;0(0):. 2017 [PMID: 29269042] (Immunoprecipitation, Mouse) Immunoprecipitation Mouse
Chi Pui Pang Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations Lab. Invest., 2016;0(0):. 2016 [PMID: 27841854] (ICC, Human) ICC Human
Tsz Kin Ng HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration Sci Rep, 2016;6(0):28639. 2016 [PMID: 27338780] (Western Blot, Human) Western Blot Human
Jo , Hakryul, Patterson , Victoria, Stoessel , Sean, Kuan , Chia-Yi, Hoh , Josephin Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease. PLoS ONE, 2014;9(12):e115362. 2014 [PMID: 25506911] (Western Blot, Human) Western Blot Human
Kumar , Sandeep, Berriochoa , Zachary, Ambati , Balamura, Fu , Yingbin Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium. Invest Ophthalmol Vis Sci, 2014;55(6):3842-50. 2014 [PMID: 24854852]
Jacobo , Sarah Me, Deangelis , Margaret, Kim , Ivana K, Kazlauskas , Andrius Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. Mol Cell Biol, 2013;33(10):1976-90. 2013 [PMID: 23478260] (Immunoprecipitation, Human) Immunoprecipitation Human
Show All 11 Publications.

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Bioinformatics

Gene Symbol HTRA1
Uniprot