hnRNP U Antibody

Images

 
Western Blot: hnRNP U Antibody [NB100-2135] - Detection of Human and Mouse hnRNP-U on HeLa whole cell lysate using NB100-2135.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

hnRNP U Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 775 and the C-terminus (residue 824) of human Heterogeneous Nuclear Ribonucleoprotein U using the numbering given in entry NP_114032.1 (GeneID 3192).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HNRNPU
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:1000-1:5000
  • Immunoprecipitation 2-5 ug/mg lysate
Positive Control
hnRNP U Lysate (NBL1-11652)
Publications
Read Publication using
NB100-2135 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for hnRNP U Antibody

  • heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
  • heterogeneous nuclear ribonucleoprotein U
  • hnRNP U
  • HNRPU
  • p120 nuclear protein
  • p120
  • pp120
  • SAFA
  • SAF-AhnRNPU
  • Scaffold attachment factor A
  • U21.1

Background

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for hnRNP U Antibody (NB100-2135)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.


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(1)
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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol HNRNPU
Entrez
Uniprot