Recombinant Human HMGA2 His Protein

SDS-Page: Recombinant Human HMGA2 Protein [NBP2-23122]

• Reactivity: Hu
• Applications: PAGE
• Concentration: 0.25 mg/ml

Recombinant Human HMGA2 His Protein Summary

• Description: A recombinant protein with a C-Terminal His-tag and corresponding to the amino acids 1-109 of Human HMGA2
  
  

  Source: E.coli

  Amino Acid Sequence: MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEEDL EHHHHHH

• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: HMGA2
• Purity: >80%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • SDS-Page
• Theoretical MW: 12.8 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20 mM Tris-HCl buffer (pH 8.0), 0.2 M NaCl, 50% glycerol, 2 mM DTT, 250 mM Imidazole
• Preservative: No Preservative
• Concentration: 0.25 mg/ml
• Purity: >80%, by SDS-PAGE

Alternate Names for Recombinant Human HMGA2 His Protein

• BABL
• BABLHMGI-C
• high mobility group AT-hook 2
• High mobility group AT-hook protein 2
• high mobility group protein HMGI-C
• high-mobility group (nonhistone chromosomal) protein isoform I-C
• High-mobility group protein HMGI-C
• HMGA2
• HMGIC
• HMGICSTQTL9
• LIPO

Background

HMGA2 is a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Recombinant human HMGA2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Publications for HMGA2 Recombinant Protein (NBP2-23122)(1)

Publication using NBP2-23122

• Zhang X, Lam A, Cheng Q et al. Discovery of an NAD+ analogue with enhanced specificity for PARP1 Chemical Science 2022-01-27 [PMID: 35308855] (WB)

Bioinformatics

• Gene Symbol: HMGA2