HMGA2 Products

Description

HMGA2 encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Bioinformatics

Entrez	8091 Human
Uniprot	NM_003483 Human NP_003474 Human NP_003475 Human P52926 Human
Product By Gene ID	8091
Alternate Names	BABLHMGI-C high mobility group AT-hook 2 High mobility group AT-hook protein 2 high mobility group protein HMGI-C high-mobility group (nonhistone chromosomal) protein isoform I-C High-mobility group protein HMGI-C HMGICSTQTL9 LIPO

Research Areas for HMGA2

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Cancer