This antibody was generated by immunizing rabbits with a synthetic peptide containing amino acid residues 15-30 of human Histone H4 GAKRHRKVLRDNIQGI. This sequence is conserved across mammalian, invertebrate and plant species. An NCBI BLAST shows no cross-reactivity of this sequence with other known histones.
A 14 kDa band is observed. The has been evaluated in human, and most likely reacts with additional mammalian, invertebrate, and plant species as the immunogen sequence used to make it is conserved.
Protein G purified
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Cross reacts with Human. Predicted to react with Invertebrates and other mammals.
Alternate Names for Histone H4 Antibody
histone 4, H4
histone cluster 4, H4
Histones are relatively small proteins that contain a high proportion of positively charged amino acids, e.g., arginine and lysine. This positive charge allows histones to bind tightly to the negatively charged DNA. There are five basic types of histone molecules called H1, H2A, H2B, H3, and H4. Histones are abundantly present in virtually all eukaryotic cells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Histone H4: Implications in Liver Cancer Histones are highly conserved proteins that function in the organization of nuclear DNA to create chromatin in eukaryotic cells. Post-translational alterations of histones are critical to monitoring and regulating DNA structure, expression, and gene t... Read full blog post.