Gremlin 1 Antibody

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Immunohistochemistry-Paraffin: Gremlin 1 Antibody [NB100-56883] - Detection of Gremlin in human colon cancer tissue using antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Gremlin 1 Antibody Summary

Immunogen
A synthetic peptide containing amino acids QPGSRNRGRGQGRGTA (52-67) of human CKTSF1B1 (NM_013372).
Predicted Species
Mouse (94%), Rat (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GREM1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:20-1:1000
  • Immunohistochemistry-Paraffin 2.5-10 ug/ml
Application Notes
Immunohistochemistry cryosections reported in literature (See Namkoong et al, 2006 for antibody usage).
Publications
Read Publications using
NB100-56883 in the following applications:

  • IHC
    2 publications
  • 2 publications

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for Gremlin 1 Antibody

  • Cell proliferation-inducing gene 2 protein
  • CKTSF1B1gremlin 1, cysteine knot superfamily, homolog
  • Cysteine knot superfamily 1, BMP antagonist 1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
  • DAN domain family member 2
  • DAND2
  • DAND2GREMLIN
  • Down-regulated in Mos-transformed cells protein
  • DRM
  • DRMMGC126660
  • GREM1
  • gremlin 1
  • gremlin 1-like protein
  • Gremlin
  • gremlin-1
  • IHG-2
  • Increased in high glucose protein 2
  • increased in high glucose-2
  • proliferation-inducing gene 2

Background

In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Gremlin 1 Antibody (NB100-56883)(5)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC, IHC-P.


Filter By Application
IHC
(2)
IHC-P
(2)
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Filter By Species
Human
(1)
All Species

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Product General Protocols

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FAQs for Gremlin 1 Antibody (NB100-56883). (Showing 1 - 2 of 2 FAQs).

  1. Are you aware of any references in the published literature which we can use to evaluate the quality of staining?
    • Unfortunately, this antibody has not yet been used in any publications that we are aware of.
  2. Therefore I come to you: firstly, to know whether you tested the antibody for cross-reaction between the two Gremlin isoforms?
    • The immunogen for NB100-56883 comes from amino acids 52-67 of isoform 1. This sequence is not present in isoform 2 of Gremlin1, so this antibody does not cross-react with isoform 2.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol GREM1
Entrez
Uniprot