Glutamate Receptor 3 Antibody (1059821) [Alexa Fluor™ Plus 555]

• Clone: 1059821
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 555

Glutamate Receptor 3 Antibody (1059821) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects human GluR3 in direct ELISA.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Glutamate Receptor 3 Antibody (1059821) [Alexa Fluor™ Plus 555]

• AMPA 3
• AMPA3
• AMPA-selective glutamate receptor 3
• GluA3
• GluR3
• GluR-3
• GLURC
• GLUR-C
• GLUR-K3
• glutamate receptor C
• glutamate receptor subunit 3
• glutamate receptor, ionotrophic, AMPA 3
• GRIA3

Background

GluR3 is a receptor for glutamate. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiological processes. This gene belongs to a family of AMPA receptors.  GluR3 is a gene product of the GRIA3 gene and its pre-mRNA is subject to RNA editing. In humans, 80-90% of GRIA3 transcripts are edited. This allows sustained response to rapid stimuli. There is a tentative link between defective GRIA3 variants and a highly elevated risk of schizophrenia.

1. Entrez Gene: GRIA3 glutamate receptor, ionotropic, AMPA 3.
2. Seeburg PH, Higuchi M, Sprengel R. "RNA Editing of Brain Glutamate Receptor channels:  Mechanism and Physiology". Brain Res. Brain Res. Rev. 1998, May; 26(2-3):217.
3. Lomeli H, Mosbacher J, Höger T, Geiner JR, Kuner T, Monyer H, Higuchi M, Bach A, Seeburg PH., "Control of Kinetic Properties of AMPA rREceptor Channels by Nuclear RNA Editing". Science. 1994, Dec; 266(5191):1709.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.