Glut2 Antibody (205115) [Biotin]

• Applications: Flow, ICC/IF
• Clone: 205115
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Biotin
• Concentration: LYOPH

Glut2 Antibody (205115) [Biotin] Summary

• Immunogen: CHO Chinese hamster ovary cell line transfected with mouse Glut2
  Met1-Val523
  Accession # P14246
• Specificity: Detects mouse Glut2. Stains mouse Glut2-transfected NS0 cells but not NS0 control transfectants. It also detects Glut2 on mouse insulinoma beta TC-6 cells (2).
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: SLC2A2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Glut2 belongs to the facilitative glucose transporter protein family that comprises 13 members. It is an integral membrane protein with 12 transmembrane domains. Glut2 is expressed predominantly in liver, intestine, kidney and pancreatic beta -cells. It is a low-affinity glucose transporter that has been suggested to function as a glucose sensor in pancreatic beta -cells. Glut2 facilitates either glucose uptake or efflux from cells depending on the nutritional state (1).

1. Olson, A.L. and J.E. Pessin (1996) Annu. Rev. Nut. 16:235.
2. Poitout, V. et al. (1995) Diabetes 44:306.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLC2A2