GLUD1/GLUD2 Antibody (848209) [Biotin]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clone: 848209
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Biotin

GLUD1/GLUD2 Antibody (848209) [Biotin] Summary

• Immunogen: E. coli-derived recombinant human GLUD1/GLUD2
  Ser54-Thr558
  Accession # P49448
• Specificity: Detects human, mouse and rat GLUD1/GLUD2 in ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: GLUD2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for GLUD1/GLUD2 Antibody (848209) [Biotin]

• epididymis secretory sperm binding protein
• epididymis tissue sperm binding protein Li 18mP
• GDH
• GDH1
• GLUD
• GLUD1/GLUD2
• glutamate dehydrogenase (NAD(P)+)
• glutamate dehydrogenase 1, mitochondrial
• hGDH1

Background

This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GLUD2