Girdin Antibody - BSA Free

Western Blot: Girdin Antibody [NBP1-76253] - Rat brain tissue lysate with Girdin antibody at (A) 1 and (B) 2 ug/mL.

Immunocytochemistry/ Immunofluorescence: Girdin Antibody - BSA Free [NBP1-76253] - Immunofluorescence of Girdin in human brain tissue with Girdin antibody at 20 u/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

Girdin Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus human Girdin. The immunogen is located within the last 50 amino acids of Girdin. Amino Acid Squence: DKVQESRNSKSRSREQ
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CCDC88A
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/mL
  • Western Blot 1-2 ug/ml
• Control Peptide:

  Girdin Peptide (NBP1-76253PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for Girdin Antibody - BSA Free

• Akt phosphorylation enhancer
• APE
• APEGIRDIN
• CCDC88A
• coiled-coil domain containing 88A
• Coiled-coil domain-containing protein 88A
• G alpha-interacting vesicle-associated protein
• G{alpha}-interacting vesicle-associated protein
• Girders of actin filament
• Girdin
• GIV
• GIVFLJ10392
• GRDN
• GRDNAKT-phosphorylation enhancer
• HkRP1
• HkRP1Galpha-interacting vesicle-associated protein
• Hook-related protein 1
• KIAA1212DKFZp686D0630

Background

Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CCDC88A
• Uniprot:
  • NP_060554(Human)