GIPR Antibody


Immunohistochemistry-Paraffin: GIPR Antibody [NLS3842] - Analysis of anti-GIPR / GIP Receptor antibody with human brain, glioblastoma.
Immunohistochemistry-Paraffin: GIPR Antibody [NLS3842] - Analysis of anti-GIPR / GIP Receptor antibody with human pancreas, Islet of Langerhans.

Product Details

Reactivity Hu, Mk, PmSpecies Glossary
Applications IHC-P
1.0 mg/ml

Order Details

GIPR Antibody Summary

A 18 amino acid synthetic peptide within the 3rd cytoplasmic domain of human GIPR.
Integral membrane protein
Human GIPR. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GHRHR (100%), GCGR (61%), GLP2R (61%).
Predicted Species
Mouse (94%), Rat (94%), Rabbit (94%), Sheep (94%), Bovine (94%), Canine (94%), Hamster (94%), Equine (94%)
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.1% Sodium Azide
1.0 mg/ml
Immunogen affinity purified


  • Immunohistochemistry-Paraffin 32 ug/ml
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NLS3842 in the following applications:

Reactivity Notes

Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Elephant (94%), Panda (94%), Opossum (83%).

Alternate Names for GIPR Antibody

  • gastric inhibitory polypeptide receptor
  • GIP-R
  • Glucose-dependent insulinotropic polypeptide receptor
  • MGC126722
  • PGQTL2


GIPR, or Gastric Inhibitory Polypeptide Receptor, mediates GIP-induced secretion of insulin by pancreatic islet beta cells after a meal. GIP is a gastrointestinal peptide hormone of 42 aa that is released from duodenal endocrine K cells after absorption of glucose or fat. Stimulation of the GIPR on pancreatic cells activates adenylyl cyclase and mitogen-activated protein kinase, resulting in increased insulin secretion. Mice with a targeted mutation of GIPR have higher blood glucose levels with impaired initial insulin response after oral glucose load. Analysis of GIPR knockout mice suggest that GIPR defects may contribute to the pathogenesis of diabetes and obesity. Ectopic expression of functional GIPR and its coupling to steroidogenesis has been suggested to be the main cause of food-dependent Cushing's syndrome. Two isoforms of GIPR are produced by alternative splicing. GIPR expression has been reported in human bone, fetal adrenal, and pancreas. Little expression has been identified in normal adult adrenal, but overexpression of GIPR has been observed in the adrenal in food-dependent Cushing's syndrome. GIPR expression has been identified in rat brain, heart, pancreas, and small intestine. ESTs have been isolated from colon libraries.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for GIPR Antibody (NLS3842)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC-Fr.

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Product General Protocols

View specific protocols for GIPR Antibody (NLS3842): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for GIPR Antibody (NLS3842). (Showing 1 - 1 of 1 FAQ).

  1. Can you tell me about the antibody dilution of NLS3842 for IHC?
    • This antibody has been used at 32ug/mL for IHC-Paraffin but optimal dilutions should be determined by each individual researcher.

Secondary Antibodies


Isotype Controls

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Contact Information

Product PDFs


Gene Symbol GIPR

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