GIPR Products

Antibodies
GIPR Antibody (591853) [Uncon ...
GIPR Antibody (591853) [Unconjugated]
MAB8210
Species: Hu
Applications: Flow, IHC, Block
Host: Mouse Monoclonal
GIPR Antibody
GIPR Antibody
NLS1251
Species: Hu, Mu, Primate, Monkey
Applications: IHC-P
Host: Rabbit Polyclonal
GIPR Antibody
GIPR Antibody
NLS3842
Species: Hu, Mk, Pm, Bovine, Canine, Equine, Hamster, Mouse, Rabbit, Rat, Sheep
Applications: IHC-P
Host: Rabbit Polyclonal
Lysates
GIPR Overexpression Lysate (N ...
GIPR Overexpression Lysate (Native)
NBP2-04150
Applications: WB
RNAi
GIPR RNAi
GIPR RNAi
H00002696-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

GIPR, or Gastric Inhibitory Polypeptide Receptor, mediates GIP-induced secretion of insulin by pancreatic islet beta cells after a meal. GIP is a gastrointestinal peptide hormone of 42 aa that is released from duodenal endocrine K cells after absorption of glucose or fat. Stimulation of the GIPR on pancreatic cells activates adenylyl cyclase and mitogen-activated protein kinase, resulting in increased insulin secretion. Mice with a targeted mutation of GIPR have higher blood glucose levels with impaired initial insulin response after oral glucose load. Analysis of GIPR knockout mice suggest that GIPR defects may contribute to the pathogenesis of diabetes and obesity. Ectopic expression of functional GIPR and its coupling to steroidogenesis has been suggested to be the main cause of food-dependent Cushing's syndrome. Two isoforms of GIPR are produced by alternative splicing. GIPR expression has been reported in human bone, fetal adrenal, and pancreas. Little expression has been identified in normal adult adrenal, but overexpression of GIPR has been observed in the adrenal in food-dependent Cushing's syndrome. GIPR expression has been identified in rat brain, heart, pancreas, and small intestine. ESTs have been isolated from colon libraries.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Product By Gene ID 2696
Alternate Names
  • MGC126722
  • PGQTL2
  • GIP-R
  • Glucose-dependent insulinotropic polypeptide receptor
  • gastric inhibitory polypeptide receptor

Research Areas for GIPR

Find related products by research area and learn more about each of the different research areas below.

GPCR
Neuroscience

PTMs for GIPR

Learn more about PTMs related to GIPR.

Phosphorylation
Oxidation
Amidation
Acetylation

Bioinformatics Tool for GIPR

Discover related pathways, diseases and genes to GIPR. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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