GIPR Antibody

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Immunohistochemistry-Paraffin: GIPR Antibody [NLS1251] - Analysis of anti-GIPR antibody with human pancreas.

Product Details

Summary
Reactivity Hu, Mu, Rt, Mk, PmSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

GIPR Antibody Summary

Immunogen
Synthetic 19 amino acid peptide from N-terminal extracellular domain of human GIPR.
Localization
Integral membrane protein.
Specificity
Human GIPR. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GHRHR (100%).
Predicted Species
Primate (95%), Monkey (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GIPR
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 8-21 ug/ml
Application Notes
Use in Western blot reported in scientific literature (PMID: 26041107).
Publications
Read Publications using
NLS1251 in the following applications:

  • WB
    1 publication

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (95%), Canine (89%), Hamster (89%), Panda (89%), Rat (84%), Rabbit (84%). Mouse reactivity reported in scientific literature (PMID: 21245029). Rat reactivity reported in scientific literature (PMID: 26041107).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GIPR Antibody

  • gastric inhibitory polypeptide receptor
  • GIPR
  • GIP-R
  • Glucose-dependent insulinotropic polypeptide receptor
  • MGC126722
  • PGQTL2

Background

GIPR, or Gastric Inhibitory Polypeptide Receptor, mediates GIP-induced secretion of insulin by pancreatic islet beta cells after a meal. GIP is a gastrointestinal peptide hormone of 42 aa that is released from duodenal endocrine K cells after absorption of glucose or fat. Stimulation of the GIPR on pancreatic cells activates adenylyl cyclase and mitogen-activated protein kinase, resulting in increased insulin secretion. Mice with a targeted mutation of GIPR have higher blood glucose levels with impaired initial insulin response after oral glucose load. Analysis of GIPR knockout mice suggest that GIPR defects may contribute to the pathogenesis of diabetes and obesity. Ectopic expression of functional GIPR and its coupling to steroidogenesis has been suggested to be the main cause of food-dependent Cushing's syndrome. Two isoforms of GIPR are produced by alternative splicing. GIPR expression has been reported in human bone, fetal adrenal, and pancreas. Little expression has been identified in normal adult adrenal, but overexpression of GIPR has been observed in the adrenal in food-dependent Cushing's syndrome. GIPR expression has been identified in rat brain, heart, pancreas, and small intestine. ESTs have been isolated from colon libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for GIPR Antibody (NLS1251)(4)

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Product General Protocols

View specific protocols for GIPR Antibody (NLS1251): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for GIPR Antibody (NLS1251) (0)

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Secondary Antibodies

 

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Blogs on GIPR.

Inhibiting incretin GIP hormone activity in mouse and monkey models to combat obesity
By Jamshed Arslan, Pharm. D., PhD. We live in a world where 39% of adults are overweight. Our meals trigger the secretion of various gut-derived metabolic hormones called incretins. Fats and carbohydrates in our die...  Read full blog post.

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Bioinformatics

Gene Symbol GIPR
Entrez
Uniprot
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