GIPR Antibody - BSA Free

Immunohistochemistry-Paraffin: GIPR Antibody [NLS1250] - Analysis of anti-GIPR antibody with human pancreas.

• Reactivity: Hu, Rt, Bv, Ca, Eq, Pm
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

GIPR Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GIPR.
• Epitope: N-terminal extracellular domain of human
• Specificity: Human GIPR. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GHRHR (100%), TG (41%).
• Predicted Species: Primate (100%), Equine (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GIPR
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 16 ug/ml
• Application Notes: Use in Immunohistochemistry reported in scientific literature (PMID: 21185343)..

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (88%), Hamster (88%), Rat (82%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for GIPR Antibody - BSA Free

• gastric inhibitory polypeptide receptor
• GIPR
• GIP-R
• Glucose-dependent insulinotropic polypeptide receptor
• MGC126722
• PGQTL2

Background

GIPR, or Gastric Inhibitory Polypeptide Receptor, mediates GIP-induced secretion of insulin by pancreatic islet beta cells after a meal. GIP is a gastrointestinal peptide hormone of 42 aa that is released from duodenal endocrine K cells after absorption of glucose or fat. Stimulation of the GIPR on pancreatic cells activates adenylyl cyclase and mitogen-activated protein kinase, resulting in increased insulin secretion. Mice with a targeted mutation of GIPR have higher blood glucose levels with impaired initial insulin response after oral glucose load. Analysis of GIPR knockout mice suggest that GIPR defects may contribute to the pathogenesis of diabetes and obesity. Ectopic expression of functional GIPR and its coupling to steroidogenesis has been suggested to be the main cause of food-dependent Cushing's syndrome. Two isoforms of GIPR are produced by alternative splicing. GIPR expression has been reported in human bone, fetal adrenal, and pancreas. Little expression has been identified in normal adult adrenal, but overexpression of GIPR has been observed in the adrenal in food-dependent Cushing's syndrome. GIPR expression has been identified in rat brain, heart, pancreas, and small intestine. ESTs have been isolated from colon libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GIPR Antibody (NLS1250)(1)

Publication using NLS1250

• Figueiredo CP, Antunes VL, Moreira EL et al. Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus Peptides 2011-04-01 [PMID: 21185343] (IF/IHC, Rat)

Bioinformatics

• Gene Symbol: GIPR
• Entrez:
  • 2696(Human)