GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (MM0311-3P34) - Azide and BSA Free

Western Blot: GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (MM0311-3P34) [NBP2-12414] - Lysates of HEK293 cells.

• Reactivity: Hu
• Applications: WB
• Clone: MM0311-3P34
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: LYOPH

GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (MM0311-3P34) - Azide and BSA Free Summary

• Immunogen: Human recombinant GFR alpha-4/GDNF R alpha-4/Persephin receptor
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: GFRA4
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:1000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Alternate Names for GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (MM0311-3P34) - Azide and BSA Free

• GDNF family receptor alpha 4
• GDNF family receptor alpha-4
• GDNF R alpha-4
• GDNF receptor alpha-4
• GDNFR-alpha-4
• GFR alpha4
• GFR alpha-4
• GFR receptor alpha 4
• GFRA4
• GFRa-4
• GFR-alpha-4
• Persephin receptor

Background

Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRalpha-1 (previously designated GDNFR-alpha), GFRalpha-2 (also designated RETL2), GFRalpha-3 and GFRalpha-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRalpha-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GFRA4
• Uniprot:
  • NP_071422()