Host: Rat Monoclonal
Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRalpha-1 (previously designated GDNFR-alpha), GFRalpha-2 (also designated RETL2), GFRalpha-3 and GFRalpha-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRalpha-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands.
|Product By Gene ID
- GFR receptor alpha 4
- GDNF family receptor alpha-4
- Persephin receptor
- GDNF receptor alpha-4
- GDNF family receptor alpha 4
PTMs for GFR alpha-4/GDNF R alpha-4/Persephin receptor
Learn more about PTMs related to GFR alpha-4/GDNF R alpha-4/Persephin receptor.PhosphorylationGlycosylation
Bioinformatics Tool for GFR alpha-4/GDNF R alpha-4/Persephin receptor
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