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GFR alpha-4/GDNF R alpha-4/Persephin receptor Products

Antibodies
GFR alpha-4/GDNF R alpha-4/Pe ...
GFR alpha-4/GDNF R alpha-4/Perseph...
MAB1439
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Lysates
GFR alpha-4/GDNF R alpha-4/Pe ...
GFR alpha-4/GDNF R alpha-4/Perseph...
NBL1-11054
Species: Hu
Applications: WB
GFR alpha-4/GDNF R alpha-4/Pe ...
GFR alpha-4/GDNF R alpha-4/Perseph...
NBP2-11268
Species: Hu
Applications: WB
GFR alpha-4/GDNF R alpha-4/Pe ...
GFR alpha-4/GDNF R alpha-4/Perseph...
NBP2-06460
Species: Hu
Applications: WB

Description

Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRalpha-1 (previously designated GDNFR-alpha), GFRalpha-2 (also designated RETL2), GFRalpha-3 and GFRalpha-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRalpha-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands.

Bioinformatics

Entrez Human
Product By Gene ID 64096
Alternate Names
  • GDNF family receptor alpha 4
  • GDNF family receptor alpha-4
  • GDNF R alpha-4
  • GDNF receptor alpha-4
  • GDNFR-alpha-4
  • GFR alpha4
  • GFR alpha-4
  • GFR receptor alpha 4
  • GFRA4
  • GFRa-4
  • GFR-alpha-4
  • Persephin receptor