GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (215725)

• Reactivity: Hu
• Applications: WB
• Clone: 215725
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (215725) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human GFR alpha ‑4/GDNF R alpha ‑4
  Asn24-Ser245 (Ser140Cys)(predicted)
  Accession # NP_071422
• Specificity: Detects human GFR alpha ‑4/GDNF R alpha ‑4 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) GFR alpha -1, recombinant rat GFR alpha -1, rhGFR alpha -2, rhGFR alpha -3, or recombinant mouse GFR alpha -4 is observed.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: GFRA4
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (215725)

• GDNF family receptor alpha 4
• GDNF family receptor alpha-4
• GDNF R alpha-4
• GDNF receptor alpha-4
• GDNFR-alpha-4
• GFR alpha4
• GFR alpha-4
• GFR receptor alpha 4
• GFRA4
• GFRa-4
• GFR-alpha-4
• Persephin receptor

Background

GFR alpha -4 is a member of a family of at least four cysteine-rich GPI-linked cell surface proteins that function as ligand binding subunits for the GDNF family (GDNF, neurturin, persephin and artemin). A functional receptor complex is achieved through association with the c-Ret receptor tyrosine kinase. GFR alpha -4 preferentially binds persephin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (MAB1439)(2)

Publications using MAB1439

• Iwasaki, T;Akeda, K;Kawaguchi, K;Yamada, J;Hasegawa, T;Takegami, N;Fujiwara, T;Sudo, A; Expression of Glial-Cell-Line-Derived Neurotrophic Factor Family Ligands in Human Intervertebral Discs International journal of molecular sciences 2023-11-01 [PMID: 37958856] (Western Blot, Human)
• Frank L. Rice, George Houk, James P. Wymer, Sara J. C. Gosline, Justin Guinney, Jianqiang Wu et al. The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin PLOS ONE 2019-05-20 [PMID: 31107888]

Bioinformatics

• Gene Symbol: GFRA4
• Uniprot:
  • NP_071422()