GATA-2 Antibody [Phycoerythrin]

TF-1 human erythroleukemic cell line was stained with Goat Anti-Human GATA-2 PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # IC2046P, filled histogram) or control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Intracellular Molecules.

• Reactivity: Hu
• Applications: Flow
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Phycoerythrin

GATA-2 Antibody [Phycoerythrin] Summary

• Immunogen: E. coli-derived recombinant human GATA-2
  Ala15-Thr279
  Accession # P23769
• Specificity: Detects human GATA-2. In direct ELISAs and Western blots, this antibody shows less than 1% cross-reactivity with rhGATA-1, rhGATA-5 and rhGATA-6.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: GATA2
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Intracellular Staining by Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GATA-2 Antibody [Phycoerythrin]

• endothelial transcription factor GATA-2
• FLJ45948
• GATA binding protein 2
• GATA2
• GATA-2
• GATA-binding protein 2NFE1B
• MGC2306

Background

GATA factors constitute a family of transcriptional regulatory factors that bind to the consensus DNA sequence (A/T) GATA (A/G) to control diverse tissue-specific programs of gene expression and morphogenesis. GATA-1/2/3 are each expressed in the hematopoietic system while GATA 4/5/6 are each expressed in the developing heart and in gastrointestinal and gut-derived tissues (1, 2).

1. Tsai, S.F. et al. (1989) Nature 339:446.
2. Jiang, Y. and T. Evans (1996) Dev. Biol. 174:258.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GATA-2 Antibody (IC2046P)(1)

Publication using IC2046P

• Juan Bautista Menendez-Gonzalez, Samantha Sinnadurai, Alex Gibbs, Leigh-anne Thomas, Maria Konstantinou, Alfonso Garcia-Valverde et al. Inhibition of GATA2 restrains cell proliferation and enhances apoptosis and chemotherapy mediated apoptosis in human GATA2 overexpressing AML cells Scientific Reports 2019-08-21 [PMID: 31434974]

Bioinformatics

• Gene Symbol: GATA2
• Uniprot:
  • P23769()