GATA-2 Products

Description

The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells (Tsai et al., 1994 [PubMed 8078582]). GATA1 (MIM 305371) is essential for normal primitive and definitive erythropoiesis and is expressed at high levels in erythroid cells, mast cells, and megakaryocytes. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells. In chicken erythroid progenitors, forced expression of GATA2 promotes proliferation at the expense of differentiation (Briegel et al., 1993 [PubMed 8504932]). GATA3 (MIM 131320) expression is restricted to T-lymphoid cells and some nonhematopoietic cell types, including embryonic stem cells.[supplied by OMIM]

Bioinformatics

Entrez	2624 Human
Uniprot	AAH18988 Human NM_032638 Human NP_001139133 Human NP_116027.2 Human P23769 Human
Product By Gene ID	2624
Alternate Names	endothelial transcription factor GATA-2 FLJ45948 GATA binding protein 2 GATA-binding protein 2NFE1B MGC2306