GABARAP Antibody [DyLight 405]

• Reactivity: Mu
• Applications: IHC, ICC/IF (-), WB (-)
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 405

GABARAP Antibody [DyLight 405] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: A synthetic peptide made to an N-terminal region of the human GABARAP protein (within residues 1-50). [Swiss-Prot O95166]
• Localization: Endomembrane system. Cytoplasm. Golgi apparatus membrane. Note: Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GABARAP
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin 1:200
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP1-97416. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for GABARAP Antibody [DyLight 405]

• Apg8p1
• ATG8A
• FLC3B
• FLJ25768
• GABA(A) receptor-associated proteinMGC120154
• GABARAP
• gamma-aminobutyric acid receptor-associated protein
• MM46
• MM46MGC120155

Background

In several neurological diseases, GABARAP expression is related to autophagic functions. In Lewy body disease and Parkinson's disease, LC3 and GABARAP are often co-localized. Autophagy is regulated both at the transcriptional and post-transcriptional level, partially by the activation of GABARAP and other core autophagy machinery proteins. Although autophagy is usually considered to be important in cellular maintenance, and breakdown of proteins and organelles in cell death, it is becoming more and more clear that it plays an important role in the developmental process, including embryogenesis. This embryological effect seems to be partly regulated by GABARAP expression and activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GABARAP