GABARAP Antibody [DyLight 550]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications IHC, IHC-P, ICC/IF (-), WB (-)
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 550

GABARAP Antibody [DyLight 550] Summary

Immunogen
A synthetic peptide made to an N-terminal region of the human GABARAP protein (within residues 1-50). [Swiss-Prot O95166]
Localization
Endomembrane system. Cytoplasm. Golgi apparatus membrane. Note: Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GABARAP
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin 1:200
Application Notes
This GABARAP antibody is useful for IHC-paraffin embedded sections. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. This antibody is not applicable in Western Blot or ICC.

Reactivity Notes

Mouse

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for GABARAP Antibody [DyLight 550]

  • Apg8p1
  • ATG8A
  • FLC3B
  • FLJ25768
  • GABA(A) receptor-associated proteinMGC120154
  • GABARAP
  • gamma-aminobutyric acid receptor-associated protein
  • MM46
  • MM46MGC120155

Background

In several neurological diseases, GABARAP expression is related to autophagic functions. In Lewy body disease and Parkinson's disease, LC3 and GABARAP are often co-localized. Autophagy is regulated both at the transcriptional and post-transcriptional level, partially by the activation of GABARAP and other core autophagy machinery proteins. Although autophagy is usually considered to be important in cellular maintenance, and breakdown of proteins and organelles in cell death, it is becoming more and more clear that it plays an important role in the developmental process, including embryogenesis. This embryological effect seems to be partly regulated by GABARAP expression and activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics Tool for GABARAP Antibody (NBP1-97416R)

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Blogs on GABARAP.

Breakdown: Interpreting LC3 Antibody WB Results
In rodents, MAPLC3 (Microtubule-associated protein 1 light chain 3) is expressed in the renal visceral epithelial cells, or podocytes. LC3 antibody analysis has shown the protein accumulates in its membrane-bound form of LC3II, following conversion fr...  Read full blog post.

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Bioinformatics

Gene Symbol GABARAP
Entrez