GABA-A R gamma 2 [p Ser327] Antibody

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Western Blot: GABA-A R gamma 2 [p Ser327] Antibody [NBP1-28661] - Western blot of rat cortex showing specific immunolabeling of the ~45k GABA-A R gamma 2 protein phosphorylated at Ser327 (control). Immunolabeling is ...read more

Product Details

Summary
Reactivity Mu, Rt, Hu, Mu, Bv, Ca, Ch, PmSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

GABA-A R gamma 2 [p Ser327] Antibody Summary

Immunogen
Phosphopeptide corresponding to amino acid residues surrounding the phosphoSer327 of the GABAA receptor, gamma 2 subunit.
Modification
p Ser327
Specificity
Specific for ~45k GABAA receptor gamma 2 subunit phosphorylated at Ser327. Immunolabeling of the GABAA band is completely blocked by lambda-phosphatase treatment.
Predicted Species
Human (100%), Mouse (100%), Bovine (100%), Chicken (100%), Canine (100%), Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GABRG2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for GABA-A R gamma 2 [p Ser327] Antibody

  • CAE2
  • ECA2
  • GABA A R gamma 2
  • GABA(A) receptor subunit gamma-2
  • GABAAR gamma 2
  • GABAARg2
  • GABRG2
  • gamma-aminobutyric acid (GABA) A receptor, gamma 2
  • gamma-aminobutyric acid receptor subunit gamma-2
  • GEFSP3

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. It has recently been suggested that PKC-E regulates the sensitivity of GABAA alpha1beta2gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2 (Qi et al., 2007)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

FAQs for GABA-A R gamma 2 Antibody (NBP1-28661). (Showing 1 - 1 of 1 FAQ).

  1. I am looking for a "Primary antibody for GABAa receptor gamma 2" raised from antigen whose aa sequence is between exon 5-10. The application will be for "Immunohistochemistry". I would like to know if you have a product to match it?
    • NB300-190 is direceted against GABA A receptor gamma 2, is suitable for use in IHC and uses a fusion protein from the cytoplasmic loop of the gamma 2 subunit as an antigen, so this should suit your needs.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol GABRG2
Entrez
Uniprot