Western Blot: GABA-A R beta 3 [p Ser409, p Ser408] Antibody [NBP2-29508] - Western blot of rat hippocampal lysate showing specific immunolabeling of the ~53k GABA-A R beta 3 protein phosphorylated at Ser408/409 ...read more
GABA-A R beta 3 [p Ser409, p Ser408] Antibody Summary
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser408/409 conjugated to KLH
p Ser409, p Ser408
Specific for the ~53k GABAA receptor beta 3 subunit phosphorylated at Ser408/409. Immunolabeling of the GABAA band is completely blocked by the phospho-peptide used as antigen but not by the corresponding dephospho-peptide.
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
53 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
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Alternate Names for GABA-A R beta 3 [p Ser409, p Ser408] Antibody
GABA A R beta 3
GABA(A) receptor beta-3 subunit
GABA(A) receptor subunit beta-3
GABAA receptor beta-3 subunit
GABA-alpha receptor beta-2 subunit
GABAAR beta 3
gamma-aminobutyric acid (GABA) A receptor, beta 3
gamma-aminobutyric acid receptor subunit beta-3
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. Phosphorylation of serine 408 and serine 409 within the beta-3 subunit have been shown to be critical for the functional modulation of beta-3 containing recombinant receptors (Brandon et al., 2000).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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