GABA-A R beta 3 [p Ser409, p Ser408] Antibody

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Western Blot: GABA-A R beta 3 [p Ser409, p Ser408] Antibody [NBP2-29508] - Western blot of rat hippocampal lysate showing specific immunolabeling of the ~53k GABA-A R beta 3 protein phosphorylated at Ser408/409 ...read more

Product Details

Summary
Reactivity Mu, Rt, Hu, Mu, Bv, Ca, Ch, Pm, Xp, ZeSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

GABA-A R beta 3 [p Ser409, p Ser408] Antibody Summary

Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser408/409 conjugated to KLH
Modification
p Ser409, p Ser408
Specificity
Specific for the ~53k GABAA receptor beta 3 subunit phosphorylated at Ser408/409. Immunolabeling of the GABAA band is completely blocked by the phospho-peptide used as antigen but not by the corresponding dephospho-peptide.
Preparation
Method
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.
Predicted Species
Human (100%), Mouse (100%), Zebrafish (100%), Bovine (100%), Chicken (100%), Canine (100%), Primate (100%), Xenopus (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GABRB3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
Theoretical MW
53 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NBP2-29508 in the following applications:

  • WB
    2 publications

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for GABA-A R beta 3 [p Ser409, p Ser408] Antibody

  • ECA5
  • GABA A R beta 3
  • GABA(A) receptor beta-3 subunit
  • GABA(A) receptor subunit beta-3
  • GABAA receptor beta-3 subunit
  • GABA-alpha receptor beta-2 subunit
  • GABAAR beta 3
  • GABAARb3
  • GABRB3
  • gamma-aminobutyric acid (GABA) A receptor, beta 3
  • gamma-aminobutyric acid receptor subunit beta-3
  • MGC9051

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. Phosphorylation of serine 408 and serine 409 within the beta-3 subunit have been shown to be critical for the functional modulation of beta-3 containing recombinant receptors (Brandon et al., 2000).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for GABA-A R beta 3 Antibody (NBP2-29508)(3)

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Bioinformatics

Gene Symbol GABRB3
Entrez
Uniprot