FYB/ADAP/SLAP130 Antibody - BSA Free

Western Blot: FYB/ADAP/SLAP130 Antibody [NBP1-76810] - K562 cell lysate with FYB antibody at (A) 0.5 and (B) 1 ug/ml.

Immunocytochemistry/ Immunofluorescence: FYB/ADAP/SLAP130 Antibody - BSA Free [NBP1-76810] - Immunocytochemistry of FYB/ADAP/SLAP130 in K562 cells with FYB/ADAP/SLAP130 antibody at 10 ug/mL.

• Reactivity: Hu, Mu
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

FYB/ADAP/SLAP130 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit FYB/ADAP/SLAP130 Antibody - BSA Free (NBP1-76810) is a polyclonal antibody validated for use in WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 20 amino acid synthetic peptide from near the carboxy terminus of human ADAP. The immunogen is located within amino acids 640 - 690 of ADAP. Amino Acid Squence: LKGKDDRKKSIREKPKVSD
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: FYB1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 10-20 ug/ml
  • Western Blot 0.5-1 ug/ml
• Control Peptide:

  FYB/ADAP/SLAP130 Peptide (NBP1-76810PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for FYB/ADAP/SLAP130 Antibody - BSA Free

• ADAP
• Adhesion and degranulation promoting adaptor protein
• adhesion and degranulation-promoting adaptor protein
• FYB
• FYB-120/130SLAP-130FYN-binding protein (FYB-120/130)
• FYN binding protein
• FYN-binding protein
• FYN-T-binding protein
• p120/p130
• PRO0823
• SLAP130
• SLP-76-associated phosphoprotein

Background

The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappaB family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FYB1
• Uniprot:
  • NP_001456(Human)