FRS2 Antibody (462910)

Images

 
Western blot shows lysates of MCF‑7 human breast cancer cell line, C2C12 mouse myoblast cell line, and PC‑12 rat adrenal pheochromocytoma cell line. PVDF membrane was probed with 1 µg/mL of Goat ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clone
462910
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

FRS2 Antibody (462910) Summary

Immunogen
E. coli-derived recombinant human FRS2
Asn121-Asn449
Accession # Q8WU20
Specificity
Detects human, mouse, and rat FRS2 in Western blots.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
FRS2
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Reviewed Applications
Read 1 Review rated 4
using
MAB4069 in the following application:

Publications
Read Publications using
MAB4069 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS and NaCl with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FRS2 Antibody (462910)

  • FGFR signalling adaptor
  • FGFR-signaling adaptor SNT
  • fibroblast growth factor receptor substrate 2
  • FRS2
  • FRS2A
  • FRS2alpha
  • SNT
  • SNT1
  • SNT-1FGFR substrate 2
  • Suc1-associated neurotrophic factor target 1

Background

FRS2 (FGF R substrate 2; also known as SNT and FRS2 alpha ) is a 70‑90 kDa member of the FRS family of lipid-anchored docking proteins. It is an intermediary between FGF R and other RTK receptors and their Ras/MAPK signaling cascades. FRS2 contains a membrane-anchoring myristoylation signal (aa 1‑6), a PTB domain (aa 13‑115) that interacts with FGF and NGF receptors, and a C-terminal Tyr-rich region (aa 196‑471) that serves as a docking site for GRB‑2 and SHP‑2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu, Mu, Rt
Applications: WB

Publications for FRS2 Antibody (MAB4069)(5)

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 1 application: Western Blot.


Filter By Application
Western Blot
(5)
All Applications
Filter By Species
Human
(4)
Rat
(1)
All Species
Showing Publications 1 - 5 of 5.
Publications using MAB4069 Applications Species
S Wu, T Ou, N Xing, J Lu, S Wan, C Wang, X Zhang, F Yang, Y Huang, Z Cai Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer Nat Commun, 2019;10(1):720. 2019 [PMID: 30755618] (Western Blot, Human) Western Blot Human
E Terzuoli, F Corti, G Nannelli, A Giachetti, S Donnini, M Ziche Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1 Int J Mol Sci, 2018;19(9):. 2018 [PMID: 30200598] (Western Blot, Human) Western Blot Human
L Xu, X Meng, N Xu, W Fu, H Tan, L Zhang, Q Zhou, J Qian, S Tu, X Li, Y Lao, H Xu Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth Cell Death Dis, 2018;9(3):262. 2018 [PMID: 29449529] (Western Blot, Human) Western Blot Human
Spichtig D, Zhang H, Mohebbi N, Pavik I, Petzold K, Stange G, Saleh L, Edenhofer I, Segerer S, Biber J, Jaeger P, Serra A, Wagner C Renal expression of FGF23 and peripheral resistance to elevated FGF23 in rodent models of polycystic kidney disease. Kidney Int, 2014;85(6):1340-50. 2014 [PMID: 24402093] (Western Blot, Rat) Western Blot Rat
Bryant MR, Marta CB, Kim FS, Bansal R Phosphorylation and lipid raft association of fibroblast growth factor receptor-2 in oligodendrocytes. Glia, 2009;57(9):935-46. 2009 [PMID: 19053057] (Western Blot, Human) Western Blot Human

Review for FRS2 Antibody (MAB4069) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Mouse.

Reviews using MAB4069:
Filter by Applications
WB
(1)
All Applications
Filter by Species
Mouse
(1)
All Species
Images Ratings Applications Species Date Details
  4
reviewed by:
Anonymous
WB Mouse 02/20/2015
View

Summary

ApplicationWestern Blot
Sample TestedSee PMID 19735729
SpeciesMouse

Blocking

Blocking DetailsSee PMID 19735729

Details

Detection NotesSee PMID 19735729

Comments

CommentsIndependent review from antibodyresource.com

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FAQs for FRS2 Antibody (MAB4069) (0)

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Recent Reviews

4
5
0
4
1
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0
2
0
1
0

 
Anonymous
02/20/2015
Application: WB
Species: Mouse

Bioinformatics

Gene Symbol FRS2
Uniprot