FRS2 Antibody (462910) [Alexa Fluor™ Plus 488]

• Clone: 462910
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

FRS2 Antibody (462910) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human, mouse, and rat FRS2 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FRS2 Antibody (462910) [Alexa Fluor™ Plus 488]

• FGFR signalling adaptor
• FGFR-signaling adaptor SNT
• fibroblast growth factor receptor substrate 2
• FRS2
• FRS2A
• FRS2alpha
• SNT
• SNT1
• SNT-1FGFR substrate 2
• Suc1-associated neurotrophic factor target 1

Background

FRS2 (FGF R substrate 2; also known as SNT and FRS2 alpha ) is a 70‑90 kDa member of the FRS family of lipid-anchored docking proteins. It is an intermediary between FGF R and other RTK receptors and their Ras/MAPK signaling cascades. FRS2 contains a membrane-anchoring myristoylation signal (aa 1‑6), a PTB domain (aa 13‑115) that interacts with FGF and NGF receptors, and a C-terminal Tyr-rich region (aa 196‑471) that serves as a docking site for GRB‑2 and SHP‑2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.