FRS2 Products

Antibodies
FRS2 [p Tyr436] Antibody
FRS2 [p Tyr436] Antibody
AF5126
Species: Hu, Mu, Rt
Applications: WB, ICC
Host: Rabbit Polyclonal
FRS2 Antibody (462910)
FRS2 Antibody (462910)
MAB4069
Species: Hu, Mu, Rt
Applications: WB
Host: Mouse Monoclonal
FRS2 Antibody [Unconjugated]
FRS2 Antibody [Unconjugated]
AF4069
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
Conjugate Catalog # Availability Size Price
Antibody Pairs
FRS2 Antibody Pair
FRS2 Antibody Pair
H00010818-PW1
Species: Hu
Applications: WB, IP
Lysates
FRS2 Overexpression Lysate (D ...
FRS2 Overexpression Lysate (Denatu...
H00010818-T01
Species: Hu
Applications: WB
FRS2 Overexpression Lysate (N ...
FRS2 Overexpression Lysate (Native)
NBP2-08387
Applications: WB
FRS2 Overexpression Lysate (N ...
FRS2 Overexpression Lysate (Native)
NBL1-10836
Applications: WB
Proteins
FRS2 Partial Recombinant Prot ...
FRS2 Partial Recombinant Protein
H00010818-Q01
Species: Hu
Applications: WB, ELISA, PA
FRS2 Recombinant Protein
FRS2 Recombinant Protein
H00010818-P02
Species: Hu
Applications: WB, ELISA, PA
RNAi
FRS2 RNAi
FRS2 RNAi
H00010818-R02
Species: Hu
FRS2 RNAi
FRS2 RNAi
H00010818-R01
Species: Hu

Description

FGFs (Fibroblast Growth Factors) bind to FGF receptors (FGFRs) monovalently, and FGF receptor dimerization and activation is mediated by multivalent interactions between heparin sulfate proteoglycans and FGF. Upon activation, receptor tyrosine kinases undergo rapid autophosphorylation on numerous tyrosine residues. Autophosphorylation sites located within the catalytic domain are crucial for stimulation of kinase activity, while autophosphorylation sites located in other regions are usually involved in the recruitment of cellular target proteins. Fibroblast growth factor or nerve growth factor (NGF) stimulation leads to tyrosine phosphorylation of the FGF Receptor Substrate 2 (FRS2) docking proteins. FRS2 is also designated SNT (Suc-1 associated neurotrophic factor target protein). Two structurally similar forms of FRS2 are: FRS2a (SNT-1) and FRS-2b (SNT-2, FRS3). FRS functions as a lipid-anchored docking protein that is tyrosine phosphorylated and recruited to FGFR upon FGF stimulation. FRS2 plays an important role in linking FGF and NGF with the Ras/MAPK signaling pathway, thus relaying information from the cell surface to the nucleus. FRS2 contains both a consensus myristylation sequence, involved in its recruitment to the cell membrane and a putative phosphotyrosine binding (PTB)domain in its amino-terminus. The interaction of FRS2 with FGFR1 occurs via the PTB domain of FRS2 binding to a 12-residue segment in the juxtamembrane region of FGFR1. FRS2a contains four binding sites for the adaptor protein Grb2 and two binding sites for the protein tyrosine phosphatase Shp2. FGF stimulation leads to phosphorylation of Shp2 on a tyrosine residue forming a complex with an additional molecule of Grb2. Grb2/Sos complexes are thus recruited directly and indirectly via Shp2 upon tyrosine phosphorylation of FRS2a in response to growth factor stimulation. It has been shown that FRS2 proteins are tyrosine phos phorylated in response to activation of the RET receptor, a tyrosine kinase that functions as the signal transducing receptor for the GDNF.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 10818
Alternate Names
  • FGFR signalling adaptor
  • SNT1
  • SNT
  • FRS2alpha
  • FGFR-signaling adaptor SNT
  • FRS2A
  • SNT-1FGFR substrate 2
  • Suc1-associated neurotrophic factor target 1
  • fibroblast growth factor receptor substrate 2

Research Areas for FRS2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Signal Transduction

PTMs for FRS2

Learn more about PTMs related to FRS2.

Phosphorylation
Ubiquitination
Glycosylation
Acetylation

Bioinformatics Tool for FRS2

Discover related pathways, diseases and genes to FRS2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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