FRS2 Antibody (462902) [Alexa Fluor™ Plus 647]

• Clone: 462902
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

FRS2 Antibody (462902) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human FRS2 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FRS2 Antibody (462902) [Alexa Fluor™ Plus 647]

• FGFR signalling adaptor
• FGFR-signaling adaptor SNT
• fibroblast growth factor receptor substrate 2
• FRS2
• FRS2A
• FRS2alpha
• SNT
• SNT1
• SNT-1FGFR substrate 2
• Suc1-associated neurotrophic factor target 1

Background

FRS2 (FGFR substrate 2; also SNT and FSR2-alpha ) is a 70‑90 kDa member of the FSR family of lipid-anchored docking proteins. It is an intermediary between FGF and TRK receptors, and their Ras/MAPK signaling cascades. Human FRS2 is 512 amino acids (aa) in length. It contains a membrane-anchoring myristoylation signal (aa 1‑6), a PTB domain that interacts with FGF and NGF receptors (aa 13‑115), and a C-terminal Tyr-rich region that serves as a docking site for Grb2 and Shp2 (aa 196‑471). One splice form shows a deletion of the C-terminal four amino acids. Over aa 121‑449, human FRS2 is 99% and 94% aa identical to dog and mouse FRS2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.